This research study explores the addition of chromium (Cr⁶⁺) ions as a nucleating agent in the alumino-silicate-glass (ASG) system (i.e., Al₂O₃-SiO₂-MgO-B₂O₃-K₂O-F). The important feature of this study is the induction of nucleation/crystallization in the base glass matrix on addition of Cr⁶⁺ content under annealing heat treatment (600 ± 10 °C) only. The melt-quenched glass is found to be amorphous, which in the presence of Cr⁶⁺ ions became crystalline with a predominant crystalline phase, Spinel (MgCr₂O₄). Microstructural experiment revealed the development of 200–500 nm crystallite particles in Cr⁶⁺-doped glass-ceramic matrix, and such type microstructure governed the mechanical properties. The machinability of the Cr-doped glass-ceramic was thereby higher compared to base alumino-silicate glass (ASG). From the nano-indentation experiment, the Young’s modulus was estimated 25(±10) GPa for base glass and increased to 894(±21) GPa for Cr-doped glass ceramics. Similarly, the microhardness for the base glass was 0.6(±0.5) GPa (nano-indentation measurements) and 3.63(±0.18) GPa (micro-indentation measurements). And that found increased to 8.4(±2.3) (nano-indentation measurements) and 3.94(±0.20) GPa (micro-indentation measurements) for Cr-containing glass ceramic.

Modelling and simulation have now become standard methods that serve to cut the economic costs of R&D for novel advanced systems. This paper introduces the study of modelling and simulation of the infrared thermography process to detect defects in the hydroelectric penstock. A 3-D penstock model was built in ANSYS version 19.2.0. Flat bottom holes of different sizes and depths were created on the inner surface of the model as an optimal scenario to represent the subsurface defect in the penstock. The FEM was applied to mimic the heat transfer in the proposed model. The model’s outer surface was excited at multiple excitation frequencies by a sinusoidal heat flux, and the thermal response of the model was presented in the form of thermal images to show the temperature contrast due to the presence of defects. The harmonic approximation method was applied to calculate the phase angle, and its relationship with respect to defect depth and defect size was also studied. The results confirmed that the FEM model has led to a better understanding of lock-in infrared thermography and can be used to detect subsurface defects in the hydroelectric penstock.

Objective: To evaluate the imaging features of spondyloarthritis on magnetic resonance imaging (MRI) of the sacroiliac (SI) joints in terms of topography (in thirds) and affected margin, since this aspect is rarely addressed in the literature. Methods: Cross-sectional study with MRI (1.5 T) evaluation of the SI in 16 patients with diagnosis of axial spondyloarthritis regarding the presence of acute (subchondral bone edema, enthesitis, synovitis and capsulitis) and chronic changes (erosions, subchondral bone sclerosis, bone bridging and fatty replacement), performed by two radiologists, blinded to clinical data. MRI findings were correlated with clinical data including age, disease duration, medications, HLA-B27, BASDAI, ASDAS-VHS and ASDAS-PCR, BASMI, BASFI, and mSASSS. Results: Bone edema pattern and erosions showed predominance in the upper third of SI (p = 0.050, p = 0.0014, respectively). There was a correlation between the time of disease and structural changes by affected third (p = 0.028-0.037), as well as the presence of bone bridges with BASMI (p = 0.028) and mSASSS (p = 0.014). Patients with osteitis of the lower third had higher ASDAS values (ESRV: p = 0.011 and CRP: p = 0.017). Conclusion: Chronic inflammatory changes and the pattern of bone edema predominated in the upper third of the SI, but there was also concomitant involvement of the middle or lower thirds of the joint. The localization of involvement in the upper third of the SI was insufficient to differentiate between degeneration and inflammation.

The danger of riverbed processes is considered. Their speed varies from the first few months of the flood to the most dynamic process in nature. It happened in front of people. This may make life on the river bank and the utilization of river resources more difficult. This paper introduces the causes and consequences of the danger performance of riverbed processes, and focuses on the mapping methods of the danger assessment of riverbed processes: determining the danger degree of riverbed processes and different methods of displaying it on the map. An example of displaying danger on the previously drawn map is given, and the distribution of different types and expression degrees of dangerous riverbed processes under various natural conditions in Russia is briefly analyzed.

Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.