The fast-growing field of nanotheranostics is revolutionizing cancer treatment by allowing for precise diagnosis and targeted therapy at the cellular and molecular levels. These nanoscale platforms provide considerable benefits in oncology, including improved disease and therapy specificity, lower systemic toxicity, and real-time monitoring of therapeutic outcomes. However, nanoparticles' complicated interactions with biological systems, notably the immune system, present significant obstacles for clinical translation. While certain nanoparticles can elicit favorable anti-tumor immune responses, others cause immunotoxicity, including complement activation-related pseudoallergy (CARPA), cytokine storms, chronic inflammation, and organ damage. Traditional toxicity evaluation approaches are frequently time-consuming, expensive, and insufficient to capture these intricate nanoparticle-biological interactions. Artificial intelligence (AI) and machine learning (ML) have emerged as transformational solutions to these problems. This paper summarizes current achievements in nanotheranostics for cancer, delves into the causes of nanoparticle-induced immunotoxicity, and demonstrates how AI/ML may help anticipate and create safer nanoparticles. Integrating AI/ML with modern computational approaches allows for the detection of potentially dangerous nanoparticle qualities, guides the optimization of physicochemical features, and speeds up the development of immune-compatible nanotheranostics suited to individual patients. The combination of nanotechnology with AI/ML has the potential to completely realize the therapeutic promise of nanotheranostics while assuring patient safety in the age of precision medicine.
Graphene has been ranked among one of the most remarkable nanostructures in the carbon world. Graphene modification and nanocomposite formation have been used to expand the practical potential of graphene nanostructure. The overview is an effort to highlight the indispensable synthesis strategies towards the formation of graphene nanocomposites. Consequently, graphene has been combined with useful matrices (thermoplastic, conducting, or others) to attain the desired end material. Common fabrication approaches like the in-situ method, solution processing, and melt extrusion have been widely involved to form the graphene nanocomposites. Moreover, advanced, sophisticated methods such as three- or four-dimensional printing, electrospinning, and others have been used to synthesize the graphene nanocomposites. The focus of all synthesis strategies has remained on the standardized graphene dispersion, physical properties, and applications. However, continuous future efforts are required to resolve the challenges in synthesis strategies and optimization of the parameters behind each technique. As the graphene nanocomposite design and properties directly depend upon the fabrication techniques used, there is an obvious need for the development of advanced methods having better control over process parameters. Here, the main challenging factors may involve the precise parameter control of the advanced techniques used for graphene nanocomposite manufacturing. Hence, there is not only a need for current and future research to resolve the field challenges related to material fabrication, but also reporting compiled review articles can be useful for interested field researchers towards challenge solving and future developments in graphene manufacturing.
One of the most frequently debated subjects in international forums is economic growth, which is regarded as a global priority. Consequently, researchers have turned their attention from conventional economic growth at a single average coefficient to divisible economic growth at levels of its value. Although the existing literature has discussed several determinants of economic growth, our article contributes to examining the sources of economic growth in African countries during the generations of reforms from 1990 to 2019 and in the context of economic vulnerability. The variables used in the analysis are gross domestic product, trade openness, financial development, and economic vulnerability. The study uses a quantile regression econometric model to examine these variables at different stages of reform. Quantile regression (QR) estimates for quantiles 0.05 to 0.95 showed mixed results: financial development is favorable to African economic growth at all quantile levels. However, economic vulnerability is a major impediment to economic growth at all quantile levels. In addition, it was found that a high degree of trade openness has a detrimental effect on African economic growth from quantile 0.5 of the dependent variable. Finally, another important result proves that financial development is a remedy for decision-makers against economic vulnerability.
This study explores the impact of technological innovations on audit transparency, objectivity, and assurance. The study employs a systematic literature review methodology, analyzing a wide range of scholarly articles, research papers, and reports to synthesize the findings. The methodology involved identifying keywords, conducting comprehensive searches in academic databases, and evaluating the selected literature. The study identifies key themes on how technological innovations impact audit practices through analysis of the literature. The impacts of technology include enhanced audit transparency through improved documentation capabilities, real-time reporting, and increased stakeholder engagement. Technological advancements bolster audit objectivity by automating repetitive tasks, facilitating advanced data analysis, and promoting standardized audit procedures. However, the analysis highlighted challenges associated with the use of technology in audits including complex technology implementation and the potential for biases. This research study contributes to the existing body of knowledge by consolidating relevant research and insights on the subject matter.
To investigate the effect of the location of vacuum insulation panels on the thermal insulation performance of marine reefer containers, a 20ft mechanical refrigeration reefer container was employed in this paper, and the physical and mathematical models of three kinds of envelopes composed of vacuum insulation panels (VIP) and polyurethane foam (PU) were numerically established. The heat transfer of three types of envelopes under unsteady conditions was simulated. In order to be able to analyze theoretically, the Rasch transform is used to analyze the thermal inertia magnitude by calculating the thermal transfer response frequency and the thermal transfer response coefficient for each model, and the results are compared with the simulation results. The results implied that the insulation performance of VIP external insulation is the best. The delay times of each model obtained from the simulation results are 0.81 h, 1.45 h, 2.03 h, and 2.24 h, while the attenuation ratios are 8.93, 20.39, 20.62, and 21.78, respectively; the delay times calculated from the theoretical analysis are 0.78 h, 1.43 h, 1.99 h, and 2.20 h, respectively; and the attenuation ratios are 8.84, 20.31, 20.55, and 21.72, respectively. The carbon reduction effect of VIP external insulation is also the best. The most considerable carbon reduction is 3.65894 kg less than the traditional PU structure within 24 h. The research has a guiding significance for the research and progress of the new generation of energy-saving reefer containers and the insulation design of the envelope of refrigerated transportation equipment.
The problem of flooding in the capital is still classified as a classic problem, but this problem still continues to emerge and becomes a trending problem during the rainy season in urban weather. This research aims to analyze the effectiveness of governance collaboration in overcoming the Jakarta flood problem. This research uses qualitative analysis and a content analysis approach. This research found that flood management using a collaborative governance approach was running optimally, the involvement of the private sector and the community was a good and rare synergy. support from international funding sources is used with effective management with the aim of using the budget on target. In the end, this research concludes that collaborative governance in Jakarta flood management is carried out optimally but requires sustainable collaborative efforts. This research has limitations in reaching the involvement of personal actors as a source of supporting information in disaster mitigation studies. Further research requires a more comprehensive discussion by reviewing the involvement of important actors in flood disaster mitigation.
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