Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

Alfalfa is considered the most used forage crop in the world, its main use is for cattle feeding, due to its high nutritional value, specifically in protein and digestible fiber. Currently, the trend in agriculture is to reduce the application of chemicals and among them are fertilizers that pollute soil and water, so the adoption of new technologies and other not so new is becoming a good habit among farmers. Nanotechnology in the plant system allows the development of new fertilizers to improve agricultural productivity and the release of mineral nutrients in nanoforms, which has a wide variety of benefits, including the timing and direct release of nutrients, as well as synchronizing or specifying the environmental response. Biofertilizers are important components of integrated nutrient management and play a key role in soil productivity and sustainability. While protecting the environment, they are a cost-effective, environmentally friendly and renewable source of plant nutrients to supplement chemical fertilizers in the sustainable agricultural system. Nanotechnology and biofertilization allow in a practical way the reduction in the application of chemicals, contributing to the sustainability of agriculture, so this work aims to review the relevant results on biofertilization, the use of nanotechnology and the evaluation of the nutritional composition of alfalfa when grown with the application of biofertilizers.

Banana macropropagation in a thermal chamber is an economical technology, effective as a phytosanitary cleaning method, and efficient to enhance seedling production. The objective of this work was to evaluate the effects of corm size (CS) and benzylaminopurine (BAP) on plantain cv. Barraganete seedling proliferation in two propagation environments (PE). The treatments consisted of two levels of BAP (with and without BAP), three CS (2 ± 0.5, 4 ± 0.5 and 6 ± 0.5 kg) and two PE (thermal chamber and raised bed). The variables evaluated were sprouting time (days), multiplication rate (MT) per unit (seedlings per corm) and area (seedlings per m²). Sprouting time was significantly influenced (p < 0.05) by the PE, where the thermal chamber advanced shoot emergence by 12 days, with respect to the raised bed. MT of seedlings per corm and m², were significantly influenced (p < 0.05) by BAP × AP and TC × AP interactions, where the highest seedling production per corm occurred inside thermal chamber with BAP and 6 ± 0.5 kg corms, while seedling production per m² was higher with 2 ± 0.5 kg corms under the same thermal chamber conditions and with BAP. The main effects results reported that with BAP there were 30 and 31% increases in MT per corm and per m², respectively, relative to the treatment without BAP. Within the thermal chamber the MT per corm and per m² increased by 44% relative to the raised bed. Regarding the effect of CS, larger corms achieved higher individual MT, while smaller corms achieved higher MT per area. The use of a thermal chamber and BAP is recommended for mass production of banana seedlings through macropropagation.

The heat collection evaporator was modeled based on equilibrium homogeneous theory, and the Runge-Kutta calculation method was used to analyze and solve the flow in the heat collection evaporator. The influence of environmental factors such as solar irradiance, ambient temperature and wind speed on the variation of refrigerant pressure in two kinds of heat collecting evaporator was analyzed under the set working conditions. The results show that the solar energy irradiance has a great influence on the pressure drop in the tube of serpentine heat collecting evaporator, and the maximum pressure drop of the refrigerant in the tube is 16.3%, minimum pressure drop is 7.8%. However, it has little influence on the pressure drop of the tube sheet evaporator. The maximum pressure drop in the refrigerant tube of the tube sheet evaporator is 4.8%, minimum pressure drop is 1.8%. When the irradiance reaches 800 W/m², the refrigerant in the serpentine-tube evaporator has been completely vaporized at 6 m, it’s completely vaporized at 3 m.

The objective of the work was to evaluate and compare the physicochemical characteristics of an experimental cabotiá hybrid with the commercial hybrid Tetsukabuto. The genotypes were divided according to mass (kg), and were evaluated for quality. The color parameters evaluated showed no significant difference, although visually the hybrid was different from the commercial variety. It was possible to conclude that the size of the fruits does not influence the concentration of the compounds, and also, an inferiority of HC05 was observed with respect to the relevant quality characteristics in pumpkins, such as soluble solids content, carotenoids and vitamin C.

This work evaluates the physical and physical-chemical parameters of the strawberry variety “Festival”, obtained in the soil and climate conditions of Humpata, Huila Province, Angola, following the transformation into sweet of adequate quality. The analyses made were: the mass determined on an analytical balance and the transversal and longitudinal diameters with a pachymeter. Other analyses were: total titratable acidity by volumetry, pH by potentiometry, total soluble solids by refractometry, moisture and ash by gravimetry. The study showed that the pH of the pulp was 3.41; and in the candy it was 3.31. The titratable acidity in the strawberry pulp had a value of 0.186 g/100 mL and in the jam 0.096 g/100 mL; the ascorbic acid content in the pulp was 18.60 mg∕100 g. The average soluble solids content in the pulp was 9.51 °Brix and for the jam 68.83 °Brix. These chemical characteristics of the pulp and jam provide information about their nutritional values.