This multiple case study qualitative research examined the impact of adoption and diffusion of innovation on Small and Medium Enterprises (SME’s) growth in the hostile business landscape of Khyber-Pakhtunkhwa, Pakistan. This research is intended to investigate research data and consequent findings based on an interview protocol that was purposefully developed from extant literature, complemented by an initial pilot study of two pharmaceutical SMEs. The researcher conducted 20 interviews, guided by the semi-structured interview protocol offered to the respondents beforehand after sorting their informed consent. The 20 participants represented the different hierarchal levels of the 08 case study of pharmaceutical from the two industrial clusters of Khyber Pakhtunkhwa, Pakistan, located at the Hayatabad Industrial Estate, Peshawar, and the Rashkai Industrial Estate, Nowshera. The analysis of the data presented findings and corroborated the research propositions that those SMEs that are structurally entrepreneurial and adopt innovation amenably, are open to mobility and tourism, yield satisfactory results in terms of their growth as compared to those that are inertial and unentrepreneurial. Similarly, the results offer confirmation that the effectiveness of government agencies that are explicitly formed to address the problems of small businesses is insufficient. They rather create hindrances than assistance due to the excessive delays in approving innovative ideas and conceptions by these related organizations and ministries. Moreover, the proposed framework offers pragmatic recommendations to contextualize entrepreneurial culture and innovative structures in SMEs and their essential factors in critical environmental circumstances.

Modelling and simulation have now become standard methods that serve to cut the economic costs of R&D for novel advanced systems. This paper introduces the study of modelling and simulation of the infrared thermography process to detect defects in the hydroelectric penstock. A 3-D penstock model was built in ANSYS version 19.2.0. Flat bottom holes of different sizes and depths were created on the inner surface of the model as an optimal scenario to represent the subsurface defect in the penstock. The FEM was applied to mimic the heat transfer in the proposed model. The model’s outer surface was excited at multiple excitation frequencies by a sinusoidal heat flux, and the thermal response of the model was presented in the form of thermal images to show the temperature contrast due to the presence of defects. The harmonic approximation method was applied to calculate the phase angle, and its relationship with respect to defect depth and defect size was also studied. The results confirmed that the FEM model has led to a better understanding of lock-in infrared thermography and can be used to detect subsurface defects in the hydroelectric penstock.

According to the World Health Organization (WHO), breast cancer is among the most common cancers worldwide. Most of the anticancer agents have been showing a variety of side effects. Recently, bacterial proteins have been investigated as promising anticancer agents. Azurin is a bacterial cupredoxin protein secreted from Pseudomonas aeruginosa and has been reported as a potent multi-targeting anticancer agent, which makes it an appropriate candidate for drug delivery. Azurin may be delivered to cancer cells using different carriers like polymeric micro and nanoparticles. In the present study, azurin was extracted from the bacterial host and loaded into chitosan particles. Then its effect on MCF-7 cell line was investigated. Chitosan-azurin particles were made using the ion gelation method. Results showed that chitosan-azurin particles are about 200 nm, and the loading of the protein in particles did not affect its integrity. The MTT assay showed a significant reduction in cell viability in azurin and chitosan-azurin-treated cells. The toxicity level after 5 days was 63.78% and 82.53% for free azurin and chitosan-azurin-treated cells, respectively. It seems using an appropriate carrier system for anticancer proteins like azurin is a promising tool for developing low side effect anticancer agents.

Background: Through the development of robust techniques and their comprehensive validation, cardiac magnetic resonance imaging (CMR) has developed a wide range of indications in its almost 25 years of clinical use. The recording of cardiac volumes and systolic ventricular function as well as the characterization of focal myocardial scars are now part of standard CMR imaging. Recently, the introduction of accelerated image acquisition technologies, the new imaging methods of myocardial T1 and T2 mapping and 4-D flow measurements, and the new post-processing technique of myocardial feature tracking have gained relevance. Method: This overview is based on a comprehensive literature search in the PubMed database on new CMR techniques and their clinical application. Results and conclusion: This article provides an overview of the latest technical developments in the field of CMR and their possible applications based on the most important clinical questions.

The range migration algorithm (RMA) is an accurate imaging method for processing synthetic aperture radar (SAR) signals. However, this algorithm requires a big amount of computation when performing Stolt mapping. In high squint and wide beamwidth imaging, this operation also requires big memory size to store the result spectrum after Stolt mapping because the spectrum will be significantly expanded. A modified Stolt mapping that does not expand the signal spectrum while still maintains the processing accuracy is proposed in this paper to improve the efficiency of the RMA when processing frequency modulated continuous wave (FMCW) SAR signals. The modified RMA has roughly the same computational load and required the same memory size as the range Doppler algorithm (RDA) when processing FMCW SAR data. In extreme cases when the original spectrum is significantly modified by the Stolt mapping, the modified RMA achieves better focusing quality than the traditional RMA. Simulation and real data is used to verify the performance of the proposed RMA.

A three-factor experiment was set at the Horticulture Laboratory, Hajee Mohammad Danesh Science and Technology University, Dinajpur, to study the effects of the controlled deterioration (CD) on the pea seeds at the constant temperature of 35 ℃. The 3 factors considered were: 3 pea seed sources (Rangpur Local/RL, Dinajpur Local/DL and Thakurgaon Local/TL); 3 ageing periods (0, 8 and 16 days); and 3 seed moisture contents (12, 16 and 20% MC). The 27 treatment combinations compared in the CRD with the 3 repetitions for the 8 arenas were: % germination, % abnormal seedlings, % dead seeds, % soil emergence and seedling evaluation test for the root and shoot lengths as well as their dry matter contents. Identical prototypes of notable (5–1% level) degradations were recorded everywhere. But the disparities were lucid under the extreme stresses. Moreover, highly noteworthy (1% level) relations were traced amid all the traits ranging from -0.9847 (soil emergence × abnormal seedling) to 0.9623 (soil emergence × normal seedling). So, the CD technique was very effectual in judging the physiological statuses of the seed sources studied. Thus, the germination test might be add-on by a vigor test, the latter of which could be assessed by quantifying the seedlings’ root and shoot lengths and/or their dry matter accumulations. Moreover, in the seed quality certification, the suitable limits of vigor for the chosen traits could also be got by this technique. But the seeds of several pea varieties should be exploited to fix-up the agreeable limits of the traits. Furthermore, to save time, the ageing period could be squeezed by raising the seed MC.