The range migration algorithm (RMA) is an accurate imaging method for processing synthetic aperture radar (SAR) signals. However, this algorithm requires a big amount of computation when performing Stolt mapping. In high squint and wide beamwidth imaging, this operation also requires big memory size to store the result spectrum after Stolt mapping because the spectrum will be significantly expanded. A modified Stolt mapping that does not expand the signal spectrum while still maintains the processing accuracy is proposed in this paper to improve the efficiency of the RMA when processing frequency modulated continuous wave (FMCW) SAR signals. The modified RMA has roughly the same computational load and required the same memory size as the range Doppler algorithm (RDA) when processing FMCW SAR data. In extreme cases when the original spectrum is significantly modified by the Stolt mapping, the modified RMA achieves better focusing quality than the traditional RMA. Simulation and real data is used to verify the performance of the proposed RMA.

Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

We examine the role of the North Aceh Government in implementing the Law on the Governing of Aceh (LoGA) as a legal structure in development policy. As a symbol of peace, the LoGA is a reference for accelerating development to alleviate poverty, including North Aceh as a conflict region. However, until now, the area remains the poorest in the province of Aceh. This research used descriptive qualitative methods, evaluating the local government’s performance as policymakers based on the Law by reconstructing policy theory (Easton) and legal system (Friedman). Our findings indicated that the local government needed help implementing LoGA to form development policies to solve poverty. This research suggested the importance of providing legal certainty in the distribution of authority, capacity building, and strengthening of political will for local government conducting its role.

The sustainable development of Madeira Island necessitates the implementation of more precise and targeted planning strategies to address its regional challenges. Given the urgency of this issue within the context of sustainability, planning approaches must be grounded in and reinforced by a comprehensive array of thematic studies to fully grasp the complexities involved. This research leverages Geographic Information Systems (GIS) to analyze land use and occupancy patterns and their evolution within the municipality of Machico on Madeira Island. The study provides a nuanced perspective on the urban structure’s stagnation in the region, while concurrently highlighting the dynamic shifts in agricultural practices. Furthermore, it elucidates the transformation of predominant native vegetation within the municipality from 1990 to 2018. Notably, the research underscores the alarming decline in native vegetation due to anthropogenic activities, emphasizing the need for more rigorous monitoring by regional authorities to safeguard and preserve these valuable landscapes, habitats, and ecosystems.