In the face of growing disruptions within the unconventional business environment, this study focuses on enhancing supply chain resilience through strategically reforming resources. It highlights the importance of understanding the dynamics and interactions of resources to tackle supply chain vulnerability (SCV) in the manufacturing sector. Employing the Decision-Making Trial and Evaluation Laboratory (DEMATEL) methodology alongside an adapted Analytic Network Process (ANP), the research investigates supply chain vulnerabilities in Pakistan’s large-scale manufacturing (LSM) public sector firms. The DANP method, through expert questionnaires, helps validate a theoretical framework by assessing the interconnectedness of supply chain readiness dimensions and criteria. Findings underscore Resource Reformation (RR) as a critical dimension, with the positive restructuring of resources identified as pivotal for public sector firms to align their operations with disruption magnitudes, advocating for a detailed analysis of resource utilization.

Urban infrastructures and services—such as public transportation, innovation bodies and environmental services—are important drivers for the sustainable development of our society. How effectively citizens, institutions and enterprises interact, how quickly technological innovations are implemented and how carefully new policies are pursued, synergically determine development. In this work, data related to urban infrastructure features such as patents and recycled waste referred to 106 province areas in Italy are investigated over a period of twenty years (2001–2020). Scaling laws with exponents characterizing the above mentioned features are observed and adopted to scrutinize whether and how multiple interactions within a population have amplification effects on the recycling and innovation performance. The study shows that there is a multiplication effect of the population size on the innovation performance of territories, meaning that the dynamic interactions among the elements of the innovation eco-systems in a territory increase its innovation performance. We discuss how to use such approach and the related indexes for understanding metropolitan development policy.

Cancer is the 3rd leading cause of death globally, and the countries with low-to-middle income account for most cancer cases. The current diagnostic tools, including imaging, molecular detection, and immune histochemistry (IHC), have intrinsic limitations, such as poor accuracy. However, researchers have been working to improve anti-cancer treatment using different drug delivery systems (DDS) to target tumor cells more precisely. Current advances, however, are enough to meet the growing call for more efficient drug delivery systems, but the adverse effects of these systems are a major problem. Nanorobots are typically controlled devices made up of nanometric component assemblies that can interact with and even diffuse the cellular membrane due to their small size, offering a direct channel to the cellular level. The nanorobots improve treatment efficiency by performing advanced biomedical therapies using minimally invasive operations. Chemotherapy’s harsh side effects and untargeted drug distribution necessitate new cancer treatment trials. The nanorobots are currently designed to recognize 12 different types of cancer cells. Nanorobots are an emerging field of nanotechnology with nanoscale dimensions and are predictable to work at an atomic, molecular, and cellular level. Nanorobots to date are under the line of investigation, but some primary molecular models of these medically programmable machines have been tested. This review on nanorobots presents the various aspects allied, i.e., introduction, history, ideal characteristics, approaches in nanorobots, basis for the development, tool kit recognition and retrieval from the body, and application considering diagnosis and treatment.

As the complexity and scale of software applications increase, the challenges associated with testing these systems grow correspondingly, necessitating innovative and sustainable testing strategies. This paper explores a multifaceted approach aimed at addressing the intricate challenges inherent in testing large-scale software applications. Through a comprehensive examination of current industry practices and emerging trends, this study introduces a novel framework that integrates advanced testing techniques with state-of-the-art tools. This framework not only mitigates the challenges posed by the complexity and size of modern applications but also enhances the efficiency and effectiveness of the testing process. Key aspects of this research include a detailed exploration of test methodologies suited for large-scale applications, an evaluation of advanced tools designed for complex test scenarios, and an analysis of the impact of the test environment on sustainability. The findings offer valuable insights and actionable strategies for software development and testing professionals aiming to optimize testing processes and improve the quality and sustainability of their software in a rapidly evolving technological landscape.

The food industry progressively requires innovative and environmentally safe packaging materials with increased physical, mechanical, and barrier properties. Due to its unique properties, cellulose has several potential applications in the food industry as a packaging material, stabilizing agent, and functional food ingredient. A coffee pod is a filter of cellulosic, non-rigid, ready-made material containing ground portions and pressed coffee prepared in dedicated machines. In our study, we obtained, with homogenization and sonication, cellulose micro/nanoparticles from three different coffee pods. It is known that nanoparticulate systems can enter live cells and, if ingested, could exert alterations in gastrointestinal tract cells. Our work aims to investigate the response of HT-29 cells to cellulose nanoparticles from coffee pods. In particular, the subcellular effects between coffee-embedded nanocellulose (CENC) and cellulose nanoparticles (NC) were compared. Finally, we analysed the pathologic condition (Cytolethal Distending Toxin (CDT) from Campylobacter jejuni) on the same cells conditioned by NC and CENC. We evidenced that, for the cellular functional features analysed, NC and CENC pre-treatments do not worsen cell response to the C. jejuni CDT, also pointing out an improvement of the autophagic flux, particularly for CENC preconditioning.

The economic viability of a photovoltaic (PV) installation depends on regulations regarding administrative, technical and economic conditions associated with self-consumption and the sale of surplus production. Royal Decree (RD) 244/2019 is the Spanish legislation of reference for this case study, in which we analyse and compare PV installation offers by key suppliers. The proposals are not optimal in RD 244/2019 terms and appear not to fully contemplate power generation losses and seem to shift a representative percentage of consumption to the production period. In our case study of a residential dwelling, the best option corresponds to a 5 kWp installation with surplus sale to the market, with a payback period of 18 years and CO₂ emission reductions of 1026 kg/year. Demand-side management offers a potential improvement of 6%–21.8%. Based on the increase in electricity prices since 2020, the best option offers savings of up to €1507.74 and amortization in 4.24 years. Considering costs and savings, sale to the market could be considered as the only feasible regulatory mechanism for managing surpluses, accompanied by measures to facilitate administrative procedures and guarantees for end users.