Cyber-physical Systems (CPS) have revolutionized urban transportation worldwide, but their implementation in developing countries faces significant challenges, including infrastructure modernization, resource constraints, and varying internet accessibility. This paper proposes a methodological framework for optimizing the implementation of Cyber-Physical Urban Mobility Systems (CPUMS) tailored to improve the quality of life in developing countries. Central to this framework is the Dependency Structure Matrix (DSM) approach, augmented with advanced artificial intelligence techniques. The DSM facilitates the visualization and integration of CPUMS components, while statistical and multivariate analysis tool such as Principal Component Analysis (PCA) and artificial intelligence methods such as K-means clustering enhance complex system the analysis and optimization of complex system decisions. These techniques enable engineers and urban planners to design modular and integrated CPUMS components that are crucial for efficient, and sustainable urban mobility solutions. The interdisciplinary approach addresses local challenges and streamlines the design process, fostering economic development and technological innovation. Using DSM and advanced artificial intelligence, this research aims to optimize CPS-based urban mobility solutions, by identifying critical outliers for targeted management and system optimization.

This research aims to identify the development of research theme trends that were carried out from 1999 to 2024. Thus, the study’s results can provide recommendations regarding research themes that can be developed to meet theoretical and practical needs. Researchers use bibliometric analysis to obtain the appropriate analysis. This analysis method can be developed to support the dynamic development of public health science with settings and researchers from developing countries, both through quantitative and qualitative interpretation. The analysis results show that over 25 years, public health science, from the perspective of researchers and developing countries, has experienced dynamic development. This change was driven by the emergence of various issues in society itself. For example, the 1999–2009 shows that lifestyle changes have resulted in multiple diseases. In the following period, the concept of sustainability emerged, which encouraged awareness of sustainable development and resource scarcity that would affect public health quality. As for the 2020–2024 period, the emergence of Covid 19 changed the previous research paradigm.