Atomic interaction between mediator protein of human prostate cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use molecular dynamics (MD) approach based on Newton’s formalism to describe the destruction of PHPC via Fe/C720 Buckyballs-Statin with atomic accuracy. In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by universal force field (UFF) and DREIDING force-field to introduce their time evolution. The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27 Å to 2.96 Å after 10 ns. Physically, these interactions causing the destruction of the PHPC. Numerically, the volume of this biostructure enlarged from 665,276 Å3 to 737,143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry. Simulations indicated the volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.

An appraisal of the groundwater potential of Alex Ekwueme Federal University Ndufu Alike was carried out by integrating datasets from geology, geographic information system and electrical resistivity survey of the area. The study area is underlain by the Asu River group of Albian age. The Asu River Group in the Southern Benue Trough comprises of Shales, Limestones and Sandstone lenses of the Abakaliki Formation in Abakaliki and Ikwo areas. The shales are generally weathered, fissile, thinly laminated and highly fractured and varies between greyish brown to pinkish red in colour. Twenty (20) Vertical Electrical Sounding data were acquired using SAS 1000 ABEM Terrameter and processed to obtain layer parameters for the study area. A maximum current electrode spacing (AB) of 300 meters was used for data acquisition. Computer aided iterative modelling using IPI2 Win was used to determine layer parameters. In-situ Hydraulic Conductivity measurements at seven parametric locations within the study area were conducted and integrated with Electrical Resistivity measurements to determine aquifer parameters (e.g., Hydraulic conductivity and Transmissivity) in real time. This technique reduces the attendant huge costs associated with pumping tests and timelines required to carry out the technique. Accurate delineation of aquifer parameters and geometries will aid water resource planners and developers on favourable areas to site boreholes in the area. Several correlative cross-sections were generated from the interpreted results and used to assess the groundwater potential of the study area. Results show that the resistivity of the the aquifer ranges from 7.3 Wm–530 Wm while depth to water ranges from 11.4 m to 55.3 m. Aquifer thicknesses range from 8.7 m at VES 5 to 36.3 m at VES 6 locations. Hydraulic conductivity ranges from 1.55 m/day at VES 15.18, and 19 locations to 9.8 m/day at VES 3 and 4 locations respectively. Transmissivity varies from 17.48 m²/day at VES 19 to 98 m²/day at VES 3 locations respectively. Areas with relatively high transmissivities coupled with good aquifer thicknesses should be the target of water resource planners and developers when proposing sites for drilling productive boreholes within Alex Ekwueme federal University Ndufu Alike.

Breast cancer was a prevalent form of cancer worldwide. Thermography, a method for diagnosing breast cancer, involves recording the thermal patterns of the breast. This article explores the use of a convolutional neural network (CNN) algorithm to extract features from a dataset of thermographic images. Initially, the CNN network was used to extract a feature vector from the images. Subsequently, machine learning techniques can be used for image classification. This study utilizes four classification methods, namely Fully connected neural network (FCnet), support vector machine (SVM), classification linear model (CLINEAR), and KNN, to classify breast cancer from thermographic images. The accuracy rates achieved by the FCnet, SVM, CLINEAR, and k-nearest neighbors (KNN) algorithms were 94.2%, 95.0%, 95.0%, and 94.1%, respectively. Furthermore, the reliability parameters for these classifiers were computed as 92.1%, 97.5%, 96.5%, and 91.2%, while their respective sensitivities were calculated as 95.5%, 94.1%, 90.4%, and 93.2%. These findings can assist experts in developing an expert system for breast cancer diagnosis.

Bagasse fiber from sugarcane waste is used with epoxy resin to make natural composites. The raw fibers are treated chemically to improve compatibility and adherence with the epoxy polymer. It’s anticipated that epoxy resin matrix composites reinforced with bagasse particles would work as a trustworthy replacement for conventional materials utilized in the building and automobile sectors. The amount and distribution of reinforcing particles inside the matrix are two factors that impact the composite’s strength. Furthermore, the precise proportion of reinforcing elements—roughly 20–30 weight percent—into the matrix plays a critical role in providing a noticeable boost in improving the properties of the composites. This research investigates the impact of reinforcing alkali-treated bagasse and untreated bagasse powder into an epoxy matrix on aspects of mechanical and morphological characteristics. The hand layup technique is used to create alkali-treated bagasse and untreated bagasse powder-reinforced epoxy composites. Composites are designed with six levels of reinforcement weight percentages (5%, 10%, 15%, 20%, 25%, and 30%). Microstructural analysis was performed using SEM and optical microscopes to assess the cohesion and dispersion of the reinforcing particles throughout the hybrid composites’ matrix phase. With reinforcement loading up to 20 wt%, the tensile strength, impact strength, and toughness of epoxy-alkali-treated bagasse and untreated bagasse powder-reinforced composites increased. In contrast, treated bagasse epoxy composites were superior to untreated epoxy composites in terms of efficacy. The results indicate that 20 wt% alkali bagasse powder provides better mechanical properties than other combinations.

The Nigerian Civil Service faces ongoing challenges in optimizing employee commitment, which is fundamental for efficient service delivery and societal progress. Hence, this paper focuses on the mediating effect of job satisfaction on talent engagement and employee commitment in the Nigerian Civil Service. The study adopted a quantitative approach, which allowed for a survey design to be adopted. A sample of 198 middle- and lower-level managers in the civil service was used. Questionnaires were used for data collection, and SmartPls 3.9 was used for data analysis. The result showed that talent engagement significantly predicts employee commitment and that job satisfaction is a good mediator in the relationship between talent engagement and employee commitment in the Nigerian Civil Service. The findings suggest that creating an engaged workforce through talent engagement can have a positive influence on employee commitment within the public sector, which can result in improved public services and contribute to overall societal development.

African countries have shown interest in developing the legal framework for electronic payment as part of digital law. The article aims to analyze the role of the legal framework for electronic payment in the field of digital economy. It relies on a legal methodology through analyzing legal texts related to electronic payment. It also relies on the comparative and descriptive approaches whenever there is a scientific necessity. The article concluded that the legal framework plays an important role in the field of digital economy. This framework appears in the general rules of civil and commercial laws or through the laws of money and credit. Other laws also play a complementary role, such as criminal law and personal data protection laws.