Protein- and peptide-based medications are recognized for their effectiveness and lower toxicity compared to chemical-based drugs, making them promising therapeutic agents. However, their application has been limited by numerous delivery challenges. Polymeric nanostructures have emerged as effective tools for protein delivery due to their versatility and customizability. Polymers’ inherent adaptability makes them ideal for meeting the specific demands of protein-delivery systems. Various strategies have been employed, such as enzyme inhibitors, absorption enhancers, mucoadhesive polymers, and chemical modifications of proteins or peptides. This study explores the hurdles associated with protein and peptide transport, the use of polymeric nanocarriers (both natural and synthetic) to overcome these challenges, and the techniques for fabricating and characterizing nanoparticles.

This study aims to explore the research on Chinese higher education policy from 2005 to 2024 through a bibliometric analysis. It is revealed that a continuous growth trend and sustained academic interest in this field. Mainland China leads in publication quantity, showcasing the active involvement of Chinese scholars in higher education policy research. Institutions like Peking University, the University of Hong Kong, and Beijing Normal University play significant roles in this research domain. The focus of research has shifted from student attitudes to international students, teachers, innovation models, changing demands, and urban education development, reflecting a growing emphasis on sustainability and internationalization. The study highlights the positive development trajectory of Chinese higher education policy research, with expanding research focuses and deepening concerns for sustainability and internationalization.

This research examines three data mining approaches employing cost management datasets from 391 Thai contractor companies to investigate the predictive modeling of construction project failure with nine parameters. Artificial neural networks, naive bayes, and decision trees with attribute selection are some of the algorithms that were explored. In comparison to artificial neural network’s (91.33%) and naive bays’ (70.01%) accuracy rates, the decision trees with attribute selection demonstrated greater classification efficiency, registering an accuracy of 98.14%. Finally, the nine parameters include: 1) planning according to the current situation; 2) the company’s cost management strategy; 3) control and coordination from employees at different levels of the organization to survive on the basis of various uncertainties; 4) the importance of labor management factors; 5) the general status of the company, which has a significant effect on the project success; 6) the cost of procurement of the field office location; 7) the operational constraints and long-term safe work procedures; 8) the implementation of the construction system system piece by piece, using prefabricated parts; 9) dealing with the COVID-19 crisis, which is crucial for preventing project failure. The results show how advanced data mining approaches can improve cost estimation and prevent project failure, as well as how computational methods can enhance sustainability in the building industry. Although the results are encouraging, they also highlight issues including data asymmetry and the potential for overfitting in the decision tree model, necessitating careful consideration.