The possibility of preoperative prediction of pathologic complete response in rectal cancer has been studied in order to identify patients who would respond to neoadjuvant therapy and to individualize therapeutic strategies. Endoscopic ultrasound of the rectum is an accurate method for the evaluation of local tumor and lymph node invasion. Objective: To evaluate the potential of endoscopic ultrasound as a predictor of complete pathological response to neoadjuvant treatment in patients with locally advanced rectal cancer. Material and methods: Retrospective study of patients with rectal cancer from January 2014 to December 2016. Results: We obtained a statistical association between T stage by endoscopic ultrasound and complete pathological response (p = 0.015). It is not so for N, sphincter involvement, circumferential involvement and maximum tumor thickness (p = 0.723, p = 0.510, p = 0.233 and p = 0.114, respectively). When multivariate logistic regression analysis was applied to assess the degree of influence of the predictor variables on pathologic response, none of these variables was associated with complete pathologic response. Conclusion: Prediction of pathologic complete response in rectal cancer has been considered as the crucial point upon which treatments for rectal cancer could be individualized. So far, no imaging method has been able to demonstrate efficacy in predicting complete pathologic response, and in turn there is no direct association between any endosonographic finding that can accurately predict it.

The micro staring hyperspectral imager can simultaneously acquire two spatial and one spectral images, and only record the external orientation elements of the entire hyperspectral image rather than the external orientation elements of each frame of the image, which avoids the geometric instability during scanning, effectively solves the problem of large geometric deformation of the small line scanning hyperspectral imager, and is suitable for the small UAV load platform with unstable attitude. At present, most of the research focuses on the radio-metric correction method of line scan hyperspectral imager. The application time of staring hyperspectral imager is short, and there is no mature data processing re-search at home and abroad, which hinders the application of UAV micro staring hyperspectral imaging system. In this paper, the calibration method of the linearity and variability of the radiation response of the micro staring hyperspectral imager on the UAV is studied, and the effectiveness of this method is quantitatively evaluated. The results show that the hyperspectral image has obvious vignetting effect and strip phenomenon before the correction of radiation response variability. After the correction, the radiation response variation coefficient of pixels in different bands decreases significantly, and the vignetting effect and image strip decrease significantly. In this paper, a multi-target radiometric calibration method is proposed, and the accuracy of radiometric calibration is verified by comparing the calibrated hyperspectral image spectrum with the measured ground object spectrum of the ground spectrometer. The results show that the calibration results of the multi-target radiometric calibration method show better results, especially for the near-infrared band, and the difference with the surface reflectance measured by the spectrometer is small.

The wide distribution of the common beech (Fagus sylvatica) in Europe reveals its great adaptation to diverse conditions of temperature and humidity. This interesting aspect explains the context of the main objective of this work: to carry out a dendroclimatic analysis of the species Fagus sylvatica in the Polaciones valley (Cantabria), an area of transition with environmental conditions from a characteristic Atlantic type to more Mediterranean, at the southern limit of its growth. The methodology developed is based on the analysis of 25 local chronologies of growth rings sampled at different altitudes along the valley, generating a reference chronology for the study area. Subsequently, the patterns of growth and response to climatic variations are estimated through the response and correlation function, and the most significant monthly variables in the annual growth of the species are obtained. Finally, these are introduced into a Geographic Information System (GIS) where they are cartographically modeled in the altitudinal gradient through multivariate analysis, taking into account the different geographic and topographic variables that influence the zonal variability of the species response. The results of the analyses and cartographic models show which variables are most determinant in the annual growth of the species and the distribution of its climatic response according to the variables considered.

In the history of public health, space has evolved through several stages driven by shifts in concepts of disease control. The history of public health is summarized by George Rosen in six phases: Origins (before 500 CE), Middle Ages (500–1500), Mercantilism and Absolutism (1500–1750), Enlightenment and Revolution (1750–1830), Industrialism and the Sanitary Movement (1830–1875), and the Bacteriological Era (1875–present). By integrating architectural sociology—a temporal lens examining the interplay between architecture, individuals, and society—this study investigates how architects historically responded to public health challenges, offering critical insights for contemporary healthy habitat design. Architecture not only addresses survival needs but also materializes societal consciousness. The progression of health-related cognition (e.g., germ theory), behavioural norms (e.g., hygiene practices), infrastructure systems (e.g., sanitation networks), and scientific advancements collectively redefined spatial paradigms. Architects constructed temples, thermae, lazarettos, Beitian Yangbingfang (charitable infirmaries), anatomical theaters, quarantine hospitals, tenements, mass housing, and biosafety laboratories. These cases exemplify the co-evolution of “Concept” (disease control ideologies), “Technology” (construction methods), and “Space” (built environments). By synthesizing centuries of public health spatial practices, this research deciphers the dynamic interplay among “Concept, Technology, and Space”. Leveraging historical patterns, we propose a predictive framework to refine future spatial strategies in anticipation of emerging health crises.

This study explores the interactions between inflation and stock market. We carried out a bibliometric analysis with R package to highlight the worldwide research trends in the field, covering the period of three crises (financial, health crisis and war of Ukraine). Next, using monthly data for the period from 1 March 2020 to 31 August 2023 and based on a vector autoregressive model, impulse response and variance decomposition are performed to explore the dynamic relationships between inflation and Greek stock market. The results reveal the existence of high volatility in Athens’ stock market during COVID-19 pandemic, owning to a shock of the inflation. Regarding the period of Ukrainian war, the study verified the Fama’s hypothesis that there is a negative relationship between inflation and stock returns. The findings have significant implications for investors and policy makers.

Introduction: Growth, yield and quality of okra (Abelmoschus esculentus (L.) Moench) are related to fertilizer application, being nitrogen (N) the most outstanding, due to its direct relationship with photosynthesis and vegetative growth of the plant. Objective: The objective was to evaluate the agronomic and productivity characteristics of okra as a function of N dose. Materials and methods: The study was conducted at the experimental area of Campus Gurupi, the Universidad Federal de Tocantins (UFT), Brazil, in two planting periods (autumn/winter and spring/summer). The experimental design used was randomized block design (RBD) with six treatments (50, 100, 150, 150, 200 and 250 kg N ha^-1) and four replications. Urea was used as a source of N. The characteristics evaluated were: productivity, average fruit mass, height and plant chlorophyll index. Results: Productivity and plant height were superior in the fall/winter crop. Mean fruit mass and chlorophyll index were not influenced by planting time. For productivity, a linear response was obtained with increasing dose up to the limit of the N dose used (250 kg ha^-1), with a mean value higher than 14 t of fruit. Mean mass and plant height responded linearly to increasing N dose. Nitrogen affected the chlorophyll index, with maximum values of 45.96 and 47.19, observed in the two evaluation periods. Conclusion: Planting time and N content in the soil interacted with plant height, being favorable in the period without precipitation. N influenced all the characteristics, demonstrating the importance of nitrogen fertilization in the development of okra plants.