The H3N2 influenza virus is spiking dramatically, which is a major concern worldwide and in India. The multifunctional hetero-trimer influenza virus RNA-dependent RNA polymerase (RdRP) is involved in the generation of viral mRNA and is crucial for viral infectivity, which is directly related to the virus’s ability to survive. The goal of the current work was to use molecular docking to determine how the RdRP protein might be affected by powerful bioactive chemicals found in Calotropis gigantia latex. By applying CB-dock 2 analysis and 2D interactions, an in-silico docking study was conducted using a GC-FID (gas chromatography with flame-ionization detection) based composition profile. Tocospiro A (15%), Amyrin (7%), and Gombasterol A were found by GC-FID to be the main phytocompounds in the latex of Calotropis gigantia. The docking result showed that ligands were effectively bound to RdRP. According to interaction studies, RdRP/ligand complexes create hydrogen bonds, van der Waals forces, pi-alkyl bonds, alkyl bonds, and pi-Sigma bonds. Therefore, it was suggested that Calotropis gigantia latex may represent a possible herbal remedy to attenuate H3N2 infections based on the above findings of the fragrance profile and docking.
In many cases, the expected efficiency advantages of public-private partnership (PPP) projects as a specific form of infrastructure provision did not materialize ex post. From a Public Choice perspective, one simple explanation for many of the problems surrounded by the governance of PPPs is that the public decision-makers being involved in the process of initiating and implementing PPP projects (namely, politicians and public bureaucrats) in many situations make low- cost decisions in the sense of Kirchgässner (1948–2017). That is, their decisions may have a high impact on the wealth of the jurisdiction in which the PPP is located (most notably, on the welfare of citizen-taxpayers in this jurisdiction) but, at the same time, these decisions often only have a low impact on the private welfare of the individual decision-makers in politics and bureaucracy. The latter, for example, in many settings often have a low economic incentive to monitor/control what the private-sector partners are doing (or not doing) within a PPP arrangement. The purpose of this paper is to draw greater attention to the problems created by low-cost decisions for the governance of PPPs. Moreover, the paper discusses potential remedies arising from the viewpoint of Public Choice and Constitutional Political Economy.
From the rich results generated by the combination of psychology and education in universities, it can be seen that the experimental education school that emerged in Europe and the United States in the late 19th century was a purely empirical spirit influenced experimental behavior in education and teaching; He pioneered a scientific educational experimental model, which is a milestone in the development history of education. It first introduces scientific experimental models into educational experiments through psychology, thereby promoting the development of educational experiments towards a scientific and standardized direction. This educational experiment of positivism paradigm, which evolved from the experimental research of psychology, is also the research paradigm advocated by psychological education in colleges and universities after the combination of college psychology and scientific education.
The study aimed to investigate the concept of workplace equality as experienced and perceived by female librarians of Punjab, Pakistan. Through this investigation, the study aimed to contribute to the broader discourse on creating equitable and inclusive workplaces for women in the field of library and information science. A qualitative research method based on semi-structured interviews was employed to meet the objectives of the study. The interview guide was used to collect data from female librarians working in the Higher Education Commission’s (HEC) recognized public and private sector universities of the Punjab, Pakistan. According to the results, female librarians shared that they have faced gender-based discrimination in job allocation as male librarians were favored for tasks with additional wages or representation at corporate events. Private sector candidates reported issues related to career development opportunities as managers often restrict participation in seminars, conferences, and higher education pursuits. The study also highlighted that inequalities or discriminations affect employees motivation and enthusiasm. This study highlights issues of inequality from a female perspective in the library and information science field, contributing to a deeper understanding of the key factors to ensure equitable workplaces. This study may be a useful contribution to the body of research literature, as well as the findings may help in sensitizing the management and authorities to control the work environment to facilitate females, and to make female-oriented policies.
With the purpose of strengthening the knowledge and prevention of landslide disasters, this work develops a methodology that integrates geomorphological mapping with the elaboration of landslide susceptibility maps using geographic information systems (GIS) and the multiple logistic regression method (MLR). In Mexico, some isolated works have been carried out with GIS to evaluate slope stability. However, to date, no practical and standardized method has been developed to integrate geomorphological maps with landslide inventories using GIS. This paper shows the analysis carried out to develop a multitemporal landslide inventory together with the morphometric analysis and mapping technique for the El Estado River basin where, selected as the study area, is located on the southwestern slope of the Citlaltepetl or Pico de Orizaba volcano. The geological and geomorphological factors in combination with the high seasonal precipitation, the high degree of weathering and the steep slopes predispose its surfaces to landslides. To assess landslide susceptibility, a landslide inventory map was prepared using aerial photographs, followed by geomorphometric mapping (altimetry, slopes and geomorphology) and field work. With this information, landslide susceptibility was modeled using multiple logistic regression (MLR) within a GIS platform and the landslide susceptibility map was obtained.
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