Dushan county, Guizhou province, is located in the southernmost tip of Guizhou province. It belongs to the temperate climate of the subtropical region and is one of the centers of the karst east Asia area. The total area of the county is 242220 hectares, of which 169142 hectares are rocky desertifi cation or endangered desertification state. At present, the problem of rocky desertification has seriously affected the ecological environment of the county, which is one of the important factors that restrict the local social living standard and economic development. Therefore, it is of great significance to promote the social and economic development of the county by investigating and analyzing the spatial differentiation rules, present situation and harm of rocky desertification in Dushan county.