As the most basic cultural venue and an important public space in rural areas, the rural museum is not only an important carrier to realize the national strategy of rural revitalization, but also a key link to open up the "last kilometer" of spiritual prosperity in the common prosperity between urban and rural areas. As one of the three pilot provinces for the construction of rural museums under the State Administration of Cultural Heritage, Zhejiang Province has listed rural museums as one of the top ten practical matters for people's livelihood, and took the lead in issuing the Zhejiang Provincial Rural Museum Construction Guide (Trial) at the national level. The construction of rural museums in Zhejiang province has entered a new stage. The paper extracts and summarizes the common problems, successful experiences and typical cases existing in the actual development process of Zhejiang rural museums, and constructs the "Zhejiang paradigm" for the sustainable development of rural museums with promotion value and demonstration significance, providing Zhejiang experience for the sustainable development of national rural museums.
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.
The coupling coordination degree model is used to analyze the change law of the inherent coupling relationship between the forest economy and the ecological environment system in Heilongjiang Province from 2006 to 2018 and its causes. The results show that by combining the coupling relationship with the relative priority of under-forest economic development, the coupling relationship change can be divided into three stages, the coupling coordination degree from 2006 to 2009 is mainly on the verge of imbalance, and the under-forest economic development lags behind the development of the ecological environment. From 2010 to 2012, the coupling coordination degree changed from the reluctant coupling stage to the stage on the verge of imbalance, and the forest economy was ahead of the ecological environment development. From 2013 to 2018, the degree of coupling and coordination was in the reluctant coupling stage, and the under-forest economy and the ecological environment continued to develop in synchronize and in harmony. Therefore, according to the research results, it is proposed to establish the principle of ecological priority, adhere to the development of characteristics, improve the level of science and technology, and rationally develop the under-forest economic industry, so as to promote the coupling and coordinated development of the under-forest economy and ecological environment system in Heilongjiang Province.
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