As cities continue to face the increasing demands of urban transportation and the need for sustainable mobility solutions, the integration of intelligent transportation systems (ITS) with smart city infrastructure emerges as a promising approach. This paper presents a novel framework for integrating ITS with smart city infrastructure, aiming to address the challenges of urban transportation and promote sustainable mobility. The framework is developed through a comprehensive literature review, case studies, and stakeholder interviews, providing significant insights into the integration process. Our research outlines the key components of smart city infrastructure that can be integrated with ITS, highlights the benefits of integration, and identifies the challenges and barriers that need to be addressed. Additionally, we propose and apply evaluation methods to assess the effectiveness of ITS integration with smart city infrastructure. The results demonstrate the novelty and significance of this framework, as it significantly reduces traffic congestion, improves air quality, and enhances citizen satisfaction. This paper contributes to the existing literature by providing a comprehensive approach to integrating ITS with smart city infrastructure, offering a transformative solution for urban transportation challenges.

Interconnected components of holistic development, such as being thankful, addressing basic psychological needs, and acting effectively toward others, should be a priority for college athletes. Athletes at the College level need all-encompassing support systems to ensure their health, happiness, and success because of the special difficulties they have juggling their academic, athletic, and personal schedules. Problems with work-life balance, stress, and performance expectations all impede College Student Athletes’ holistic development. A thorough plan that considers all of the social, emotional, and psychological aspects impacting athlete development is necessary to overcome these obstacles. An Integrated Holistic Development Program for College Athletes (IHDP-CA) is suggested in this paper as a method that incorporates various aspects of positive psychology, mindfulness, resilience training, and the enhancement of interpersonal skills. Athletes at the College level can benefit from this all-encompassing program’s emphasis on helping others, developing an attitude of gratitude, and meeting basic psychological requirements. Sports counseling services, schools, and College athletic teams can all benefit from the IHDP-CA. A more positive and supportive sporting environment can be achieved when the program takes a more holistic approach to athletes’ needs, improving their mental health, social connections, and overall performance. The possible effect of the IHDP-CA on the holistic development outcomes of College Student-Athletes will be predicted through simulation analysis. To gain a better understanding of the program’s long-term viability, efficacy, and scalability, this analysis will run simulations of different situations and tweak program settings.

Instant and accurate evaluation of drug resistance in tumors before and during chemotherapy is important for patients with advanced colon cancer and is beneficial for prolonging their progression-free survival time. Here, the possible biomarkers that reflect the drug resistance of colon cancer were investigated using proton magnetic resonance spectroscopy (1H-MRS) in vivo. SW480[5-fluorouracil(5-FU)-responsive] and SW480/5-FU (5-FU-resistant) xenograft models were generated and subjected to in vivo 1H-MRS examinations when the maximum tumor diameter reached 1–1.5 cm. The areas under the peaks for metabolites, including choline (Cho), lactate (Lac), glutamine/glutamate (Glx), and myoinositol (Ins)/creatine (Cr) in the tumors, were analyzed between two groups. The resistancerelated protein expression, cell morphology, necrosis, apoptosis, and cell survival of these tumor specimens were assessed. The content for tCho, Lac, Glx, and Ins/Cr in the tumors of the SW480 group was significantly lower than that of the SW480/5-FU group (p < 0.05). While there was no significant difference in the degree of necrosis and apoptosis rate of tumor cells between the two groups (p > 0.05), the tumor cells of the SW480/5-FU showed a higher cell density and larger nuclei. The expression levels of resistance-related proteins (P-gp, MPR1, PKC) in the SW480 group were lower than those in the SW480/5-FU group (p < 0.01). The survival rate of 5-FU-resistant colon cancer cells was significantly higher than that of 5-FUresponsive ones at 5-FU concentrations greater than 2.5 μg/mL (p < 0.05). These results suggest that alterations in tCho, Lac, Glx1, Glx2, and Ins/Cr detected by 1H-MRS may be used for monitoring tumor resistance to 5-FU in vivo.

This review focuses on ferrites, which are gaining popularity with their unique properties like high electrical resistivity, thermal stability, and chemical stability, making them suitable for versatile applications both in industry and in biomedicine. This review is highly indicative of the importance of synthesis technique in order to control ferrite properties and, consequently, their specific applications. While synthesizing the materials with consideration of certain properties that help in certain methods of preparation using polyol route, green synthesis, sol-gel combustion, or other wise to tailor make certain properties shown by ferrites, this study also covers biomedical applications of ferrites, including magnetic resonance imaging (MRI), drug delivery systems, cancer hyperthermia therapy, and antimicrobial agents. This was able to inhibit the growth of all tested Gram-negative and positive bacteria as compared with pure ferrite nanoparticles without Co, Mn or Zn doping. In addition, ferrites possess the ability to be used in environmental remediation; such as treatment of wastewater which makes them useful for high-surface-area and adsorption capacity due heavy metals and organic pollutants. A critical analysis of functionalization strategies and possible applications are presented in this work to emphasize the capability of nanoferrites as an aid for the advancement both biomedical technology and environmental sustainability due to their versatile properties combined with a simple, cost effective synthetic methodology.

The rise of internet-based pharmacies has transformed the healthcare sector, giving patients access to medications, information, and direct interaction with pharmacists. While online pharmacies have become popular around the world, there are challenges hindering their widespread use in developing countries due to a limited understanding of the factors affecting their acceptance and usage. To bridge this knowledge gap, a study utilized a model combining the unified theory of acceptance and use of technology (UTAUT 2) with the technology acceptance model (TAM) to explore the drivers behind online pharmacy usage in Oman. Through this framework, twelve hypotheses were. A survey involving 378 individuals familiar with online pharmacies was conducted. Structural equation modeling (SEM) was applied to analyze the data and test these hypotheses. The results indicate that factors such as perceived expectancy effort expectancy and facilitating conditions hedonic motivation, habit perceived risk, technology trust, and technology awareness play roles in influencing the adoption of online pharmacies in Oman. The findings suggest that personal innovation plays a moderating role in the connection between perceived risk and behavioral intention, while it has a negative moderating influence on the relationship between technology trust and behavioral intention. Word of mouth was identified as a moderator in enhancing the correlation between behavioral intention and online pharmacy adoption. This research emphasizes the moderating relationship of personal innovation and word of mouth on shaping consumer attitudes towards online pharmacies and their acceptance. In summary, these results add to the existing knowledge on pharmacy adoption and in developed areas such as provide practical insights for online pharmacy providers to improve their offerings and attract a larger customer base.

Rapid urban expansion gives rise to smart cities which pose immense logistical and supply chain challenges. The COVID-19 pandemic transformed the holistic system identified by Zhao et al. in 2021. The system encompasses logistics and supply chain integral to the concept of smart cities, with a focus on sustainability. This transformation requires an in-depth study on challenges of a common framework of policies for smart cities in countries comprising the Organisation for Economic Cooperation and Development (OECD). The study employs an extensive literature analysis for the period 2020–2022. an approach which contextualizes the model. The model identifies the causes, impact, and spillovers of new trends in logistics and supply, including the sustainability of adopted technologies. The study includes the variables involved, and barriers to creating a shared model. The results reveal that the two elements affecting the supply chain and transport in smart cities are Industry 4.0 and 5.0 technologies supporting specific sectors. The resilience of small and medium-sized enterprises positively impacts the sustainability of large urban centres. The study presents both factors that help and hinder the adoption of environmental, social, and economic sustainability technologies.