Protein- and peptide-based medications are recognized for their effectiveness and lower toxicity compared to chemical-based drugs, making them promising therapeutic agents. However, their application has been limited by numerous delivery challenges. Polymeric nanostructures have emerged as effective tools for protein delivery due to their versatility and customizability. Polymers’ inherent adaptability makes them ideal for meeting the specific demands of protein-delivery systems. Various strategies have been employed, such as enzyme inhibitors, absorption enhancers, mucoadhesive polymers, and chemical modifications of proteins or peptides. This study explores the hurdles associated with protein and peptide transport, the use of polymeric nanocarriers (both natural and synthetic) to overcome these challenges, and the techniques for fabricating and characterizing nanoparticles.

The Government of Qatar is investing considerable resources in the development of integrated transport infrastructure as a solution to traffic congestion and environmental degradation. Autonomous vehicles are expected to be one of the methodologies for enhancing the quality of the built environment and fostering a more sustainable and environmentally conscious urban milieu. While autonomous cars have the potential to address urban difficulties and be utilized for personal, group, and public transit purposes, their implementation in the specific context of Doha has not been thoroughly analyzed. This research explores the potential impacts that autonomous vehicles are expected to have on travel demands, parking needs, and urban planning. It discusses the benefits and challenges associated with autonomous vehicles and predicts their likely implementation and development based on the different precedents. In addition, it explores how it will affect planning decisions such as drop-off and pick-up areas, parking and public transit. The research utilizes a qualitative approach through literature content analysis, field observations, and mobility analysis. Several case studies are analyzed to explore how autonomous vehicles can operate within a limited zone. The study uncovers the issue of ownership and mode of operation as essential factors that can affect the impact of autonomous vehicles (AVs). In addition, implementing AVs may create complex environmental concerns when greener and more sustainable transportation models are not integrated. It is recommended that Doha adopt integrated planning and implementation of AV technologies to ensure that AVs align harmoniously with the environmental stewardship requirement. The research study also presents urban design frameworks for how existing urban spaces can accommodate autonomous vehicles.

The CO₂  heat pump air conditioning system of new energy vehicle is designed, and the vehicle model of CO₂  heat pump module and heat management system is established based on KULI simulation. The effects of refrigerant charge, running time and compressor speed on the heat pump air conditioning system is studied, and the energy consumption is compared with the PTC heating system and the CO₂ heat pump air conditioning system without waste heat recovery. The results show that the optimal charge for full-service operation is 750 g; increasing the compressor speed can increase the cooling capacity, so that the refrigerant temperature in the passenger compartment and battery inlet can quickly reach the appropriate temperature, but the COP_h, COP_c are reduced by 2.5% and 1.8% respectively. By comparing it with PTC heating and CO₂ heat pump air conditioning systems without waste heat recovery, it is found that the energy consumption of this system is only for the PTC heating systems 42.5%, without waste heat recovery carbon dioxide heat pump air conditioning system of 86.6%. It greatly saves energy, but also increased the waste heat recovery function, so that the system supply air temperature increased by 26%, improve passenger cabin comfort. This  provides a reference for the future experimental research of CO₂ heat pump air conditioning and heat management system. 

The mining sector faces a complex dilemma as an economic development agent through social upliftment in places where mining corporations operate. Resource extraction is destructive and non-renewable, making it dirty and unsustainable. To ensure corporate sustainability, this paper examines the effects of knowledge management (KM), organizational learning (OL), and innovation capability (IC) on Indonesian coal mining’s organizational performance (OP). We used factor and path analysis to examine the relationships between the above constructs. After forming a conceptual model, principal component analysis validated the factor structure of a collection of observed variables. Path analysis examined the theories. The hypothesized framework was confirmed, indicating a positive association between constructs. However, due to mining industry peculiarities, IC does not affect organizational performance (OP). This study supports the importance of utilizing people and their relevant skills to improve operational performance. The findings have implications for managers of coal mining enterprises, as they suggest that KM and OL are critical drivers of OP. Managers should focus on creating an environment that facilitates knowledge sharing and learning, as this will help improve their organizations’ performance.

This paper conducts a comparative analysis of mentoring and metacognition in education, unveiling their intricate connections. Both concepts, though seemingly disparate, prove to be interdependent within the educational landscape. The analysis showcases the dynamic interplay between mentoring and metacognition, emphasizing their reciprocal influence. Metacognition, often perceived as self-awareness and introspection, is found to complement the relational and supportive nature of mentoring. Within this context, metacognitive education within mentoring emerges as a vital component. Practical recommendations are offered for effective metacognitive training, highlighting its role in enhancing cognitive and metacognitive skills. Moreover, the paper introduces the concept of a “mentoring scaffolding system.” This system emphasizes mentor-led gradual independence for mentees, facilitating their professional and personal growth. The necessity of fostering a metacognition culture in education is a central theme. Such a culture promotes improved performance and lifelong learning. The paper suggests integrating metacognition into curricula and empowering learners as essential steps toward achieving this culture. In conclusion, this paper advocates for the integration of metacognition into mentoring and education, fostering self-awareness, independence, and adaptability. These attributes are deemed crucial for individuals navigating the challenges of the information age.

This study looked at how adding augmented reality (AR) to Jordanian fast-food apps during the pandemic impacts brand identity, consumer views, and interactions. It wanted to see if AR strengthens brand connections or leads to brand dilution concerns in the industry. The research utilized a qualitative approach, employing semi-structured interviews with 52 marketing managers from diverse fast-food establishments across Jordan. The study highlighted how mobile apps, especially AR, changed brand interactions in Jordan’s fast-food market. They boosted convenience and engagement but raised worries about food quality and brand dilution due to heavy app use. It stressed the need to balance tech innovation, preserve brand identity, offer personalized experiences, understand user behavior, and tackle app development challenges for better brand loyalty. The research offers practical implications for stakeholders, recommending strategic AR integration, a user-centric approach, cultural sensitivity in tech adoption, and the preservation of emotional connections. It emphasizes the significance of maintaining a delicate balance between leveraging technological advancements and safeguarding the distinctiveness of individual brand identities within an increasingly app-centric landscape. This study uncovers AR’s influence in Jordan’s fast-food scene, highlighting its transformative power and possible drawbacks. It offers practical advice for industry players, guiding them on how to navigate the digital shift without compromising brand integrity or customer connections.