Nanotechnology is a subject that studies, processes, and applies various functional materials, equipment, and systems, and controls substances on a nanoscale. Nanomedicine refers to its application in diagnosing, treating, preventing, and monitoring various diseases. Drugs administered through eye drops must travel a long distance to avoid various eye barriers reaching the posterior segment of the eye, to achieve the lowest drug level. This review focuses on nanotechnology-based eye disease treatment systems and highlights the obstacles affecting the drug management of eyes and nano-systems for the treatment of eye diseases. This paper summarizes the development prospect of nanotechnology and the challenges it faces in the treatment and diagnosis of ophthalmic diseases, to provide information and new ideas for the implementation of treatment and the development of a refractory eye disease management system.

This article presents a methodology to perform quality analysis on the cadastral map, based on the tools provided by open (public or free) license geographic information systems (GIS). The errors presented in the cadastral map have a direct impact on the information systems, which can lead to erroneous decisions and to an increase in the costs of maintenance and updating of spatial data. The methodology developed was used and tested by Costa Rica’s Cadastre and Registry Regularization Program; as a product of this program, a continuous cadastral map has been created for Costa Rica, on which cadastral and registry transactions will be processed within the National Registry of Costa Rica. The methodology allows detecting, locating and classifying errors in the cadastral map for easily correcting, so that this map correctly represents the reality of the properties that conform it.

Different color-promoting treatments were tested on table grape cv. “Flame Seedlees” to evaluate changes on flavonoids such as anthocyanins and the residual ethylene produced. Treatments were spray-applied at the onset of veraison. The control was Ethrel at 250 ppm (ETH), Salicylic Acid at 100 ppm (AS), Melatonin at 25 ppm (MEL) and 1:1 mixtures of ETH+AS, ETH+MEL and AS+MEL. The trials were conducted in triplicate after harvest, measuring Total Soluble Solids (% TSS), total acidity (% tartaric acid), pH, residual ethylene (ppm) and anthocyanin content (mg∙cm^-2). It was found that treatments ETH, AS, MEL and ETH+AS reached 16% TSS, standing out with lower values ETH +MEL (14.27%) and AS+MEL (15.17%) (p ≤ 0.05). ETH reached 0.83 ppm of residual ethylene, while a sum effect was appreciated in ETH+AS (0.5 ppm) and ETH+MEL (0.35 ppm), but not beneficial as it did not reflect quality characteristics. Only differences (p ≤ 0.05) in anthocyanin content were recorded between ETH (0.019 mg∙cm^-2) and AS+MEL (0.003 mg∙cm^-2). The subjective color of the grape bunches in the field made it possible to relate it to the objective results of the analyses performed. This research provides commercially important information on the substitution of Ethrel by natural compounds such as AS and MEL, as they show similar effects on the quality of “Flame Seedless” table grapes. In addition, these compounds do not have an ethylene residual greater than 0.2 mg/kg.

This article presents a bibliographic review on the evolution of Geographic Information Systems (GIS) and their integration in the social sciences, which is important because the interrelation of these areas contributes to the knowledge of the people. In this sense, the objective was to contribute to the university academic knowledge, through the compilation, classification, analysis and synthesis of scientific works according to the subject treated. For this purpose, the historical, synthetic, dialectical, and analytical methods were used, with a descriptive and documentary type of research, obtaining as a result that the GIS are very useful in different fields of social sciences, ranging from archeology to sociology, including specific topics such as economics and criminology.

China’s economic structure has made subtle changes with the development of digital economy. Along with the marginal diminishing effect of Chinese monetary policies and the increase of the overall leverage ratio, the Chinese economic growth mode of relying on real estate, trade and infrastructure construction in the past will not be sustainable in the next decade. This paper makes a theoretical analysis on the reduction of the search cost in digital economy. Also, this paper used empirical methods to study the relationship between China’s economic growth and digital infrastructure construction. In conclusion, the digital economy has reduced the search cost for people, and big data will become a product factor participating in labor distribution. In addition, this paper proposes for the first time that digital economy can effectively restrain inflation. The Chinese government needs to attach importance to the issue that current internet enterprise oligarchs will probably monopolize the usage of big data in the development of digital economy in the future and become the obstacle to effective economic growth. In addition, close attention should be paid to the vulnerabilities of financial and taxation systems for digital economic entities to avoid continuous disguised tax subsidies to internet oligarchs, thus preventing industrial monopoly.

In order to study the temperature change trend of the surrounding geotechnical soil during the operation and thermal recovery of the medium-deep geothermal buried pipe and the influence of the geotechnical soil on the operational stability of the vertical buried pipe after thermal recovery. Based on the data of geological stratum in Guanzhong area and the actual engineering application of medium-deep geothermal buried pipe heating system in Xi’an New Area, the influence law of medium-deep geothermal buried pipe heat exchanger on surrounding geotechnical soil is simulated and analyzed by FLUENT software. The results show that: after four months of heating operation, in the upper layer of the geotechnical soil, the reverse heat exchange zone appears due to the higher fluid temperature; in the lower layer of the geotechnical soil, the temperature decreases more with the increase of depth and shows a linear increase in the depth direction; without considering the groundwater seepage, after eight months of thermal recovery of the geotechnical soil after heating, the maximum temperature difference after recovery is 3.02 ℃, and the average temperature difference after recovery is 1.30 ℃ The maximum temperature difference after recovery was 3.02 ℃ and the average temperature difference after recovery was 1.30 ℃. The geotechnical thermal recovery temperature difference has no significant effect on the long-term operation of the buried pipe, and it can be operated continuously and stably for a long time. Practice shows that due to the influence of various factors such as stratigraphic structure, stratigraphic pressure, radioactive decay and stratigraphic thermal conductivity, the actual stratigraphic temperature below 2000m recovers rapidly without significant temperature decay, fully reflecting the characteristics of the Earth’s constant temperature body.