China’s rapid development in modern times has become an important country in the world. Therefore, the cultures of various countries continue to cross and integrate in China. Language is the carrier of culture. Under the function of language, international culture is constantly spread and exchanged. As an important part of basic education, language education, especially college English education, significantly contains multiple international cultures. From the perspective of multiculturalism, the development status of college English teaching reflects the importance of multicultural infiltration. The following explores college English teaching strategies from the perspective of multiculturalism from three aspects: establishing “double qualified” teachers, paying attention to mother tongue and cultural differences, establishing diversified teaching concepts and establishing teaching culture evaluation system.