The development of the times and the progress of society have put forward new requirements for the conduct of party building work. Only by adhering to innovative ideas, continuously adjusting and scientifically planning the mode of party building work, can a new and systematic guidance system for party building be constructed, so that the conduct of party building work in universities presents a new development state and mode. Based on the influence of the information technology environment and the guidance of the spirit of the 20th National Congress, this article explores and analyzes the innovative reform of party building work in universities in the new era. From different perspectives such as introducing advanced technology and innovative party building work concepts, it systematically explores the innovative planning measures for party building work, striving to build a new organizational system for party building in universities, and scientifically optimize the value and effectiveness of party building work in universities.