The fast-growing field of nanotheranostics is revolutionizing cancer treatment by allowing for precise diagnosis and targeted therapy at the cellular and molecular levels. These nanoscale platforms provide considerable benefits in oncology, including improved disease and therapy specificity, lower systemic toxicity, and real-time monitoring of therapeutic outcomes. However, nanoparticles' complicated interactions with biological systems, notably the immune system, present significant obstacles for clinical translation. While certain nanoparticles can elicit favorable anti-tumor immune responses, others cause immunotoxicity, including complement activation-related pseudoallergy (CARPA), cytokine storms, chronic inflammation, and organ damage. Traditional toxicity evaluation approaches are frequently time-consuming, expensive, and insufficient to capture these intricate nanoparticle-biological interactions. Artificial intelligence (AI) and machine learning (ML) have emerged as transformational solutions to these problems. This paper summarizes current achievements in nanotheranostics for cancer, delves into the causes of nanoparticle-induced immunotoxicity, and demonstrates how AI/ML may help anticipate and create safer nanoparticles. Integrating AI/ML with modern computational approaches allows for the detection of potentially dangerous nanoparticle qualities, guides the optimization of physicochemical features, and speeds up the development of immune-compatible nanotheranostics suited to individual patients. The combination of nanotechnology with AI/ML has the potential to completely realize the therapeutic promise of nanotheranostics while assuring patient safety in the age of precision medicine.

The rise of internet-based pharmacies has transformed the healthcare sector, giving patients access to medications, information, and direct interaction with pharmacists. While online pharmacies have become popular around the world, there are challenges hindering their widespread use in developing countries due to a limited understanding of the factors affecting their acceptance and usage. To bridge this knowledge gap, a study utilized a model combining the unified theory of acceptance and use of technology (UTAUT 2) with the technology acceptance model (TAM) to explore the drivers behind online pharmacy usage in Oman. Through this framework, twelve hypotheses were. A survey involving 378 individuals familiar with online pharmacies was conducted. Structural equation modeling (SEM) was applied to analyze the data and test these hypotheses. The results indicate that factors such as perceived expectancy effort expectancy and facilitating conditions hedonic motivation, habit perceived risk, technology trust, and technology awareness play roles in influencing the adoption of online pharmacies in Oman. The findings suggest that personal innovation plays a moderating role in the connection between perceived risk and behavioral intention, while it has a negative moderating influence on the relationship between technology trust and behavioral intention. Word of mouth was identified as a moderator in enhancing the correlation between behavioral intention and online pharmacy adoption. This research emphasizes the moderating relationship of personal innovation and word of mouth on shaping consumer attitudes towards online pharmacies and their acceptance. In summary, these results add to the existing knowledge on pharmacy adoption and in developed areas such as provide practical insights for online pharmacy providers to improve their offerings and attract a larger customer base.

The integration of Big Earth Data and Artificial Intelligence (AI) has revolutionized geological and mineral mapping by delivering enhanced accuracy, efficiency, and scalability in analyzing large-scale remote sensing datasets. This study appraisals the application of advanced AI techniques, including machine learning and deep learning models such as Convolutional Neural Networks (CNNs), to multispectral and hyperspectral data for the identification and classification of geological formations and mineral deposits. The manuscript provides a critical analysis of AI’s capabilities, emphasizing its current significance and potential as demonstrated by organizations like NASA in managing complex geospatial datasets. A detailed examination of selected AI methodologies, criteria for case selection, and ethical and social impacts enriches the discussion, addressing gaps in the responsible application of AI in geosciences. The findings highlight notable improvements in detecting complex spatial patterns and subtle spectral signatures, advancing the generation of precise geological maps. Quantitative analyses compare AI-driven approaches with traditional techniques, underscoring their superiority in performance metrics such as accuracy and computational efficiency. The study also proposes solutions to challenges such as data quality, model transparency, and computational demands. By integrating enhanced visual aids and practical case studies, the research underscores its innovations in algorithmic breakthroughs and geospatial data integration. These contributions advance the growing body of knowledge in Big Earth Data and geosciences, setting a foundation for responsible, equitable, and impactful future applications of AI in geological and mineral mapping.

Mapping land use and land cover (LULC) is essential for comprehending changes in the environment and promoting sustainable planning. To achieve accurate and effective LULC mapping, this work investigates the integration of Geographic Information Systems (GIS) with Machine Learning (ML) methodology. Different types of land covers in the Lucknow district were classified using the Random Forest (RF) algorithm and Landsat satellite images. Since the research area consists of a variety of landforms, there are issues with classification accuracy. These challenges are met by combining supplementary data into the GIS framework and adjusting algorithm parameters like selection of cloud free images and homogeneous training samples. The result demonstrates a net increase of 484.59 km² in built-up areas. A net decrement of 75.44 km² was observed in forest areas. A drastic net decrease of 674.52 km² was observed for wetlands. Most of the wastelands have been converted into urban areas and agricultural land based on their suitability with settlements or crops. The classifications achieved an overall accuracy near 90%. This strategy provides a reliable way to track changes in land cover, supporting resource management, urban planning, and environmental preservation. The results highlight how sophisticated computational methods can enhance the accuracy of LULC evaluations.

This paper focuses on examining the relationship among organizational factor, work-related factor, psychological factor, personal factor and the commitment of oil palm smallholders toward Malaysian Sustainable Palm Oil (MSPO) certification. The study employed a descriptive research methodology and a structured survey instrument to gather data from oil palm smallholders (n = 441) through simple random sampling technique. Data analysis was conducted using SPSS and partial least square structural equation modeling (PLS-SEM) to test the proposed relationship. The findings reveal that organizational factors significantly impact the affective (β = 0.345, p < 0.05), normative (β = 0.424, p < 0.05), and continuance commitment (β = 0.339, p < 0.05) of oil palm smallholders. Additionally, work-related factors show a substantial effect on these same dimensions of commitment; affective (β = 0.277, p < 0.05), normative (β = 0.263, p < 0.05), and continuance (β = 0.413, p < 0.05). Psychological factors significantly impact the affective (β = 0.216, p < 0.05) and normative commitment (β = 0.146, p < 0.05), with no statistically significant influence on continuance commitment. Conversely, personal factors exhibit limited influence, affecting only continuance commitment (β = 0.104, p < 0.05) to a minor degree, with no statistically significant impact on affective and normative commitment. The present research is among the few empirical findings that have examined the oil palm smallholders’ commitment towards MSPO certification. By emphasizing the role of organizational and work-related factors, the study offers valuable insights for stakeholders within the oil palm sector, highlighting areas to enhance smallholder commitment toward sustainability standards. Consequently, this study contributes a unique perspective to the existing body of literature on sustainable practices in the oil palm industry.