The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

This study explores approaches to optimizing inclusive education through international and local perspectives. It examines the role of educators in inclusive settings, highlights strategies for early detection of children’s developmental needs, and evaluates inclusive school management practices. Using qualitative case study methods, the research includes comprehensive observations and interviews at Fatma Kenanga Islamic Character School. Findings emphasize the importance of individualized learning plans, shadow teacher involvement, and collaborative stakeholder engagement. Integrating global insights, this study contributes to advancing inclusive education practices in Indonesia and beyond.

The rapid growth of e-commerce in South Africa has increased the demand for efficient last-mile delivery. Motorcycle delivery drivers play a crucial role in the last-mile delivery process to bridge the gap between retailers and consumers. However, these drivers face significant challenges that impact both logistical efficiency and their socio-economic well-being. This study critically analyzes media narratives on the safety and working conditions of motorcycle delivery drivers in the e-commerce sector in South Africa. The thematic analysis of newspaper articles identified recurring themes. This study reveals critical safety and labor vulnerabilities affecting motorcycle delivery drivers in South Africa’s e-commerce sector. Key findings include heightened risks of violence, hijackings, and road accidents, exacerbated by inadequate infrastructure and safety gear. Coupled with low wages, job insecurity, and limited benefits, these conditions expose drivers to significant precarity. Policy interventions are urgently needed for driver safety and sustainable logistics. By integrating insights from multiple disciplines, this study offers a comprehensive understanding of the complex challenges within this rapidly growing sector.

To investigate the effect of the location of vacuum insulation panels on the thermal insulation performance of marine reefer containers, a 20^ft mechanical refrigeration reefer container was employed in this paper, and the physical and mathematical models of three kinds of envelopes composed of vacuum insulation panels (VIP) and polyurethane foam (PU) were numerically established. The heat transfer of three types of envelopes under unsteady conditions was simulated. In order to be able to analyze theoretically, the Rasch transform is used to analyze the thermal inertia magnitude by calculating the thermal transfer response frequency and the thermal transfer response coefficient for each model, and the results are compared with the simulation results. The results implied that the insulation performance of VIP external insulation is the best. The delay times of each model obtained from the simulation results are 0.81 h, 1.45 h, 2.03 h, and 2.24 h, while the attenuation ratios are 8.93, 20.39, 20.62, and 21.78, respectively; the delay times calculated from the theoretical analysis are 0.78 h, 1.43 h, 1.99 h, and 2.20 h, respectively; and the attenuation ratios are 8.84, 20.31, 20.55, and 21.72, respectively. The carbon reduction effect of VIP external insulation is also the best. The most considerable carbon reduction is 3.65894 kg less than the traditional PU structure within 24 h. The research has a guiding significance for the research and progress of the new generation of energy-saving reefer containers and the insulation design of the envelope of refrigerated transportation equipment.

A gradually detailed geophysical investigation took place on Ancient Marina territory. In that area was extended Ancient Tritaea, according to responsible Archaeological Services. The first approach had been attempted since 1988 by applied electric mapping based on a twin-probe array. Later, the survey extended to the peripheral zone under the relative request from the 6th Archaeological Antiquity. A new approach was implemented by combining three different geophysical techniques, like electrical mapping, total intensity, and vertical gradient. These were applied on discrete geophysical grids. Electric mapping tried to separate the area into low and high-interest subareas according to soil resistance allocation. That technique detected enough geometrical characteristics, which worked as the main lever for the application of two other geophysical techniques. The other two techniques would be to certify the existence of geometrical characteristics, which divorced them from geological findings. Magnetic methods were characterized as a rapid technique with greater sensitivity in relation to electric mapping. Also, vertical gradient focuses on the horizontal extension of buried remains. Processing of magnetic measurements (total and vertical) certified the results from electric mapping. Also, both of the techniques confirmed the existence of human activity results, which were presented as a cross-section of two perpendicular parts. The new survey results showed that the new findings related to results from the previous approach. Geophysical research in that area is continuing.