Over 90% of cancer-related mortality worldwide is due to metastatic disease since the dynamic tumor microenvironment poses huge challenges in preventing the spread of metastatic cancer. Introducing the advent of advance biomaterials and their swift evolution, this review highlights the great potential of innovative biomaterials to proficiently tackle the metastatic tumor environment. Focusing on four distinct categories of biomaterials systems, action mechanism of biomaterials utilized in anti-tumor therapy is explained in detail: 1. Nanoplatforms sensitive to biochemical cues including pH, redox, and enzymes are known as stimuli-responsive nanoplatforms that react according their environment, 2. Smart nanoplatforms changing their morphology to penetrate impermeable physical barriers at tumor site, 3. Ingenious biomaterial participating in tumor normalization, and 4. Nanoplatforms with real-time theranostic capabilities due to innate feedback-loop mechanism. Ingeniously structured biomaterials with extensive evidence in preclinical efficacy encourage their inclusion in metastatic tumor therapy however, their utilization in medical settings is prevented due to various challenges; impractical manufacturing cost, regulatory and safety issues as well as large-scale production are major challenges restraining their widespread use. A concrete framework is proposed in this review to accelerate the biomaterial structure standardization process, following the GMP and other regulatory guidelines with the aim of implementing biomaterial-based tumor diagnostics and therapies. Since incorporating advancing technologies in tumor therapy such AI-driven, autonomous biomaterial structure or patient-specific tumor models would enable confront the proliferating metastatic tumor cases.

In order to meet the guidance, publicity and commercial functions, various types of billboards have become important permanent facilities in the airport terminal, which are distributed all over the terminal. The advertising materials inside billboards have certain fire hazards, and there is a lack of research on the fire risk of advertising materials at present. Therefore, it is necessary to study the fire risk of advertising materials in airport terminal. Taking PVC board, a commonly used advertising material, as the research object, Pyrosim was used to model and analyze its fire, and the characteristics of fire spread, smoke flow, and distribution of combustion products such as CO and CO2 in the terminal building were obtained. This study explores the fire combustion characteristics of advertising materials in civil airport terminals, providing a basis for fire prevention management in civil airport terminals.

Heat transfer augmentation procedures, such as Heat Transfer Enhancement and Intensification, are commonly used in heat exchanger systems to enhance thermal performance by decreasing thermal resistance and increasing convective heat transfer rates. Swirl-flow devices, such as coiled tubes, twisted-tape inserts, and other geometric alterations, are commonly used to create secondary flow and improve the efficiency of heat transfer. This study aimed to explore the performance of a heat exchanger by comparing its performance with and without the use of twisted-tape inserts. The setup consisted of a copper inner tube measuring 13 mm in inner diameter and 15 mm in outer diameter, together with an outer pipe measuring 23 mm in inner diameter and 25 mm in outer diameter. Mild steel twisted tapes with dimensions of 2 mm thickness, 1.2 cm width, and twist ratios of 4.3 and 7.2 were utilised. The findings indicated that the heat transfer coefficient was 192.99 W/m² °C when twisted-tape inserts were used, while it was 276.40 W/m² °C without any inserts. The experimental results closely aligned with the theoretical assumptions, demonstrating a substantial enhancement in heat transfer performance by the utilisation of twisted-tape inserts. The study provides evidence that the utilisation of twisted-tape inserts resulted in a nearly two times increase in the heat transfer coefficient, hence demonstrating their efficacy in augmenting heat transfer.

Conspiracy theories during Covid-19 pandemic spread worldwide, including in Indonesia. What political and religious factors explain their spread in Indonesia with particular reference to the DKI Jakarta province, its surrounding municipalities, and West Sumatera province? This study aimed to answer the questions. It employed a qualitative approach with multi-data collection methods, including those from media, documents, and interviews. The spread of Conspiracy theories benefited from the democratic system that promotes the freedom of information in using social media. First, the government officials initially spread conspiracy theories to satisfy people’s anxiety about the obscured Pandemic. However, they resulted in the government’s ambiguous, controversial, and reckless policies leading to people’s distrust of the government. Jokowi-Makruf Amien, political opponents capitalized on the government’s poor policies to spread conspiracy theories which partly discredited the Jokowi-Amien administration. Both government officials and the opposition capitalized on politics and religious teaching or supra-natural pretexts to posit their conspiracy theories.

The COVID-19 pandemic has brought life changing conditions to families that require coping strategies in order to survive and achieve family well-being. This study aims to analyze differences between single earner and dual earner families during the COVID-19 pandemic and to analyze the factors that influence subjective family well-being. The research design used was a cross sectional study with sample collection through non-probability sampling. Data collection was carried out by filling out questionnaires online. The number of respondents involved in the study was 2084 intact families with children residing in DKI Jakarta, West Java, and Banten Provinces. Reliability and validity tests were conducted. The results of the independent t-test showed that dual-earner families experienced better life changes and a higher level of subjective family well-being than single-earner families and had lower economic pressure and lower economic coping than single earner families. The SEM analysis found that life changes affected economic coping negatively and subjective family well-being positively. Family income influenced economic coping negatively and subjective family well-being positively. Finally, it was found that economic coping had no effect on subjective family well-being.