Atomic interaction between mediator protein of human prostate cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use molecular dynamics (MD) approach based on Newton’s formalism to describe the destruction of PHPC via Fe/C720 Buckyballs-Statin with atomic accuracy. In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by universal force field (UFF) and DREIDING force-field to introduce their time evolution. The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27 Å to 2.96 Å after 10 ns. Physically, these interactions causing the destruction of the PHPC. Numerically, the volume of this biostructure enlarged from 665,276 Å3 to 737,143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry. Simulations indicated the volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.

The demography of Saudi Arabia has been discussed many times but its conflict with the theories of transition and associated structural changes is unexplained. This research explains the demographic differentials stated as lag - real from theoretical – separately for the native and total population. This research developed demographic indicators revealing trends and patterns by adopting a secondary data analysis method, utilizing the General Authority for Statistics census data and other online data. The demographic transition of Saudi Arabia is in line with the theoretical contentions of pretransition and transition (early, mid, and late) stages but at definite time intervals. The absolute size, percentage change, and annual growth rate are explanatory for natives and are considered separately. Moreover, the structural population changes reveal transition stages from expansive to near expansive and constricting and stabilizing. Furthermore, broad age groups indicate rapid declines in the percentage of children, rapid increases in young adults, slow increases in older adults, and no changes in older persons. Even the sex ratio of natives is at par with other populations in transition (slightly above 100). Thus, it could be concluded that a demographic transition with structural changes as per theories: flawless growth rates with an expanding demographic dividend. At this juncture, the integration of migrants into society by endorsing family life and enabling social and demographic balance appears as imperative to improving the labor sector, productivity, and the image of the country in the international spheres for comparisons and benchmarking.

This study aims to examine the entrepreneurial activities of 240 women in the districts of Konaseema, East Godavari, and Kakinada during 2021–2022, focusing on the diverse range of 286 enterprises they managed across 69 business types. These enterprises were tailored to local resources and market demands, with coconut wholesale, cattle breeding, and provision shops being the most common. The study also analyzes income distribution, noting that one-third of the women earned between ₹50,000–1,00,000 annually, while only 0.70% earned over ₹5,00,000. More than half of the enterprises served as the primary income source for their families. The research highlights the significant role these women entrepreneurs play in their communities, their job satisfaction derived from financial independence and social empowerment, and the challenges they face, such as limited capital and market access. Finally, the study offers recommendations to empower these women to seize entrepreneurial opportunities and enhance their success.

This study investigates the relationship between hydrological processes, watershed management, and road infrastructure resilience, focusing on the impact of flooding on roads intersecting with streams in River Nile State, Sudan. Situated between 16.5° N to 18.5° N latitude and 33° E to 34° E longitude, this region faces significant flooding challenges that threaten its ecological and economic stability. Using precise Digital Elevation Models (DEMs) and advanced hydrological modeling, the research aims to identify optimal flood mitigation solutions, such as overpass bridges. The study quantifies the total road length in the area at 3572.279 km, with stream orders distributed as follows: First Order at 2276.79 km (50.7%), Second Order at 521.48 km (11.6%), Third Order at 331.26 km (7.4%), and Fourth Order at 1359.92 km (30.3%). Approximately 27% (12 out of 45) of the identified road flooding points were situated within third- and fourth-order streams, mainly along the Atbara-Shendi Road and near Al-Abidiya and Merowe. Blockages varied in distance, with the longest at 256 m in Al-Abidiya, and included additional measurements of 88, 49, 112, 106, 66, 500, and 142 m. Some locations experienced partial flood damage despite having water culverts at 7 of these points, indicating possible design flaws or insufficient hydrological analysis during construction. The findings suggest that enhanced scrutiny, potentially using high-resolution DEMs, is essential for better vulnerability assessment and management. The study proposes tailored solutions to protect infrastructure, promoting sustainability and environmental stewardship.