The fast-growing field of nanotheranostics is revolutionizing cancer treatment by allowing for precise diagnosis and targeted therapy at the cellular and molecular levels. These nanoscale platforms provide considerable benefits in oncology, including improved disease and therapy specificity, lower systemic toxicity, and real-time monitoring of therapeutic outcomes. However, nanoparticles' complicated interactions with biological systems, notably the immune system, present significant obstacles for clinical translation. While certain nanoparticles can elicit favorable anti-tumor immune responses, others cause immunotoxicity, including complement activation-related pseudoallergy (CARPA), cytokine storms, chronic inflammation, and organ damage. Traditional toxicity evaluation approaches are frequently time-consuming, expensive, and insufficient to capture these intricate nanoparticle-biological interactions. Artificial intelligence (AI) and machine learning (ML) have emerged as transformational solutions to these problems. This paper summarizes current achievements in nanotheranostics for cancer, delves into the causes of nanoparticle-induced immunotoxicity, and demonstrates how AI/ML may help anticipate and create safer nanoparticles. Integrating AI/ML with modern computational approaches allows for the detection of potentially dangerous nanoparticle qualities, guides the optimization of physicochemical features, and speeds up the development of immune-compatible nanotheranostics suited to individual patients. The combination of nanotechnology with AI/ML has the potential to completely realize the therapeutic promise of nanotheranostics while assuring patient safety in the age of precision medicine.

The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

The role of trace gases in the storage of heat in the atmosphere of the Earth and in the exchange of energy between the atmosphere and outer space is discussed. The molar heat capacities of the trace gases water vapor, carbon dioxide and methane are only slightly higher than those of nitrogen and oxygen. The contribution of trace gases carbon dioxide and methane to heat storage is negligible. Water vapor, with its higher concentration and conversion energies, contributes significantly to the heat storage in the atmosphere. Most of the heat in the Earth’s atmosphere is stored in nitrogen and oxygen, the main components of the atmosphere. The trace gases act as converters of infrared radiation into heat and vice versa. They are receivers and transmitters in the exchange of energy with outer space. The radiation towards space is favored compared to the reflection towards the surface of the Earth with increasing altitude by decreasing the density of the atmosphere and condensation of water vapor. Predictions of the development of the climate over a century by extrapolation are critically assessed.

This paper discusses the concept of creating a new reality using the approaches of smart cities to develop eco-cities, in which the necessary balance between nature and progress can be maintained. The authors propose that the concept of smart cities should be used as a tool for the creation of eco-cities, and argue that the positive synergies between the two will be strongest if the smart concept acts as a tool for the creation of eco. The core elements of a smart eco-city are identified as smart sustainable use of resources, a smart sustainable healthy community, and a smart sustainable economy. The results of the article were the foundation for the development concept for Vision Bratislava 2050—the vision and strategy for the development of the capital of the Slovak Republic. The authors also discuss the challenges of transforming cities into smart eco-formats, including the need for digital resilience in the face of potential cataclysms. They suggest that this is a promising area for further research into the concept of smart eco-cities.

City planning is becoming more and more crucial as modernization and urbanization progress quickly. Making maps is an essential and helpful way in the city planning process for gathering data about the layout of a city and its elements, including the roads, traffic, buildings, and environment. Thanks to advancements in technology, computer software is now used to create maps, yielding more accurate and varied results. As a result, cartography is now closely related to and plays a crucial part in city planning. This brief essay will discuss the value of cartography in urban development and planning, as well as the connection between the two.

This study explores the determinants of auditor performance, focusing on the moderating role of organizational commitment within the Tangerang City Inspectorate. Employing stratified random sampling, a sample of 250 auditors was chosen to ensure diversity across experience, departmental affiliation, and roles. Quantitative analysis used SPSS to examine the relationships between auditor performance, organizational commitment, and other relevant variables. Findings indicated that organizational commitment significantly moderates the effects of various social pressures on auditor performance. This underscores the necessity for auditing organizations to foster organizational commitment to enhance auditor efficacy and uphold ethical standards. These results hold substantial implications for governance and audit quality assurance, suggesting that reinforced organizational commitment could lead to more robust auditor performance and ethical conduct within similar urban governance settings. This study contributes valuable insights into the influence of organizational dynamics on auditor behaviour and performance outcomes.