The fast-growing field of nanotheranostics is revolutionizing cancer treatment by allowing for precise diagnosis and targeted therapy at the cellular and molecular levels. These nanoscale platforms provide considerable benefits in oncology, including improved disease and therapy specificity, lower systemic toxicity, and real-time monitoring of therapeutic outcomes. However, nanoparticles' complicated interactions with biological systems, notably the immune system, present significant obstacles for clinical translation. While certain nanoparticles can elicit favorable anti-tumor immune responses, others cause immunotoxicity, including complement activation-related pseudoallergy (CARPA), cytokine storms, chronic inflammation, and organ damage. Traditional toxicity evaluation approaches are frequently time-consuming, expensive, and insufficient to capture these intricate nanoparticle-biological interactions. Artificial intelligence (AI) and machine learning (ML) have emerged as transformational solutions to these problems. This paper summarizes current achievements in nanotheranostics for cancer, delves into the causes of nanoparticle-induced immunotoxicity, and demonstrates how AI/ML may help anticipate and create safer nanoparticles. Integrating AI/ML with modern computational approaches allows for the detection of potentially dangerous nanoparticle qualities, guides the optimization of physicochemical features, and speeds up the development of immune-compatible nanotheranostics suited to individual patients. The combination of nanotechnology with AI/ML has the potential to completely realize the therapeutic promise of nanotheranostics while assuring patient safety in the age of precision medicine.
Plastic products are items that we use every day around us, and their replacement speed are very fast, so that to recycle waste plastic has become the focus of environmental problems. This study has proposed an optimized circular design for the recycle plant of waste plastic, therefore, and our proposed strategy is to build a new tertiary recycling plant to reduce the total generation amount of the derived solid plastic waste from ordinary and secondary recycling plants and the semi-finished products from secondary recycling plant. Results obtained from a real recycle plant has showed that to recycle the tertiary waste plastic in a tertiary recycling plant, the finished products produced from a secondary recycling plant accounts about 27% of ordinary waste plastic, and the semi-finished products that mainly is scrap hardware accounts about 1% of ordinary waste plastic. Other derived solid plastic waste accounts for 6% of ordinary plastic waste. Therefore, if the ordinary, secondary and tertiary recycle plant can be set all-in-one, it can reduce the total generation amount of derived solid plastic waste from 34% to 6%, without and with a tertiary recycling plant, respectively. It can also increase the operating income of the secondary recycle plant and the investment willingness of the new tertiary recycle plant.
In order to promote the application of noise map in high-speed railway noise management, the high-speed railway noise map drawing technology based on the combination of noise prediction model and geographic information system (GIS) is studied. Firstly, according to the distribution characteristics of noise sources and line structure characteristics of high-speed railway, the prediction model of multi equivalent sound sources and the calculation method of sound barrier insertion loss of high-speed railway are optimized; secondly, a three-dimensional geographic information model of a high-speed railway is built in GIS software, and the railway noise prediction technology based on the model is developed again; then, the noise of discrete nodes is calculated, and the continuous noise distribution map is drawn by spatial interpolation. The research results show that the comparison error between the noise map of a high-speed railway drawn by this technology and the measured results is less than 1 dB (A), which verifies the accuracy and practicality of the high-speed railway noise map, and can be used as a reference for the railway noise management department to formulate noise control countermeasures.
Fire, a phenomenon occurs in most parts of the world and causes severe financial losses, even, irreparable damages. Many parameters are involved in the occurrence of a fire; some of which are constant over time (at least in a fire cycle), but the others are dynamic and vary over time. Unlike the earthquake, the disturbance of fire depends on a set of physical, chemical, and biological relations. Monitoring the changes to predict the occurrence of fire is efficient in forest management. Method: In this research, the Persian and English databases were structurally searched using the keywords of fire risk modeling, fire risk, fire risk prediction, remote sensing and the reviewed papers that predicted the fire risk in the field of remote sensing and geographic information system were retrieved. Then, the modeling and zoning data of fire risk prediction were extracted and analyzed in a descriptive manner. Accordingly, the study was conducted in 1995-2017. Findings: Fuzzy analytic hierarchy process (AHP) zoning method was more practical among the applied methods and the plant moisture stress measurement was the most efficient among the remote sensing indices. Discussion and Conclusion: The findings indicate that RS and GIS are effective tools in the study of fire risk prediction.
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