This review comprehensively summarizes various preparatory methods of polymeric bone scaffolds using conventional and modern advanced methods. Compilations of the various fabrication techniques, specific composition, and the corresponding properties obtained under clearly identified conditions are presented in the commercial formulations of bone scaffolds in current orthopedic use. The gaps and unresolved questions in the existing database, efforts that should be made to address these issues, and research directions are also covered. Polymers are unique synthetic materials primarily used for bone and scaffold applications. Bone scaffolds based on acrylic polymers have been widely used in orthopedic surgery for years. Polymethyl methacrylate (PMMA) is especially known for its widespread applications in bone repair and dental fields. In addition, the PMMA polymers are suitable for carrying antibiotics and for their sustainable release at the site of infection.

Stimuli-responsive, smart, or intelligent polymers are materials that significantly change their physical or chemical properties when there is a small change in the surrounding environment due to either internal or external stimuli. In the last two decades or so, there has been tremendous growth in the strategies to develop various types of stimuli-responsive polymer (SRP) materials/systems that are suitable for various fields, including biomedical, material science, nanotechnology, biotechnology, surface and colloid sciences, biochemistry, and the environmental field. The wide acceptability of SRPs is due to their availability in different architectural forms such as scaffolds, aggregates, hydrogels, pickering emulsions, core-shell particles, nanogels, micelles, membranes, capsules, and layer-by-layer films. The present review focuses on different types of SRPs, such as physical, chemical, and biological, and various important applications, including controlled drug delivery (CDD), stabilization of colloidal dispersion, diagnostics (sensors and imaging), tissue engineering, regenerative medicines, and actuators. The applications of SRPs have immense potential in various fields, and the author hopes these polymers will add a new field of applications through new concepts.

Recent research efforts have increasingly concentrated on creating innovative biomaterials to improve bone tissue engineering techniques. Among these, hybrid nanomaterials stand out as a promising category of biomaterials. In this study, we present a straightforward, cost-efficient, and optimized hydrothermal synthesis method to produce high-purity Ta-doped potassium titanate nanofibers. Morphological characterizations revealed that Ta-doping maintained the native crystal structure of potassium titanate, highlighting its exciting potential in bone tissue engineering.