Over 90% of cancer-related mortality worldwide is due to metastatic disease since the dynamic tumor microenvironment poses huge challenges in preventing the spread of metastatic cancer. Introducing the advent of advance biomaterials and their swift evolution, this review highlights the great potential of innovative biomaterials to proficiently tackle the metastatic tumor environment. Focusing on four distinct categories of biomaterials systems, action mechanism of biomaterials utilized in anti-tumor therapy is explained in detail: 1. Nanoplatforms sensitive to biochemical cues including pH, redox, and enzymes are known as stimuli-responsive nanoplatforms that react according their environment, 2. Smart nanoplatforms changing their morphology to penetrate impermeable physical barriers at tumor site, 3. Ingenious biomaterial participating in tumor normalization, and 4. Nanoplatforms with real-time theranostic capabilities due to innate feedback-loop mechanism. Ingeniously structured biomaterials with extensive evidence in preclinical efficacy encourage their inclusion in metastatic tumor therapy however, their utilization in medical settings is prevented due to various challenges; impractical manufacturing cost, regulatory and safety issues as well as large-scale production are major challenges restraining their widespread use. A concrete framework is proposed in this review to accelerate the biomaterial structure standardization process, following the GMP and other regulatory guidelines with the aim of implementing biomaterial-based tumor diagnostics and therapies. Since incorporating advancing technologies in tumor therapy such AI-driven, autonomous biomaterial structure or patient-specific tumor models would enable confront the proliferating metastatic tumor cases.

The current state of the Moroccan mountains in general, and the Beni Iznassen Mountains in particular, is the result of a dynamic process that has accelerated in recent years due to rapid demographic growth and the associated pressure on mountain natural resources. This has led to significant degradation, varying in severity across different areas within the Beni Iznassen Mountain range. In the context of these imbalances between natural mountain resources and the daily needs of the local population, there has been an emergence of various challenges, such as poverty and marginalization, affecting the lives of the region’s residents and a noticeable decline in socioeconomic indicators. This situation has consequently driven migration towards regions that better meet the population’s needs. Therefore, it has become essential to pay attention to this natural area by restoring its residents’ livelihoods, breaking their isolation, and rationalizing the use of its land-based natural resources. This has made the region a focus of territorial development efforts by both the state and local stakeholders.

Ukrainian Human Resource (HR) practices have multiple difficulties from economic changes combined with digital transformation and workforce instability brought on by the war in 2022. The study examines Ukrainian HR practices between 2015 and 2024, focusing on the digitalization of HR systems, talent development, staff engagement, and hiring strategies. It considers the effects of organizational size and industry type. The study combined interviews with 30 HR professionals and surveyed 150 organizations from different industry groups and sizes. Our data required both quantitative statistical tests and manual content breakdown with codes. Research has shown significant differences between Information Technology (IT) and farming firms, as 89% of IT businesses have integrated artificial intelligence (AI)-powered HR tools. In comparison, only 15% of agricultural companies have adopted them. Small and medium-sized enterprises (SMEs) showed less commitment to digital transformation and European Union (EU) requirements than large enterprises, which adopted these systems at rates of 75% and 88%, respectively. Western Ukraine first established mental health initiatives during the crisis, and Eastern Ukraine moved toward decentralized administration. Digitalization assistance for small businesses, along with EU and local human resources frameworks, should form the basis of our suggestions. This research calls for flexible people management methods to boost the Ukrainian workspace’s ability to recover from shocks.

Graphene has been ranked among one of the most remarkable nanostructures in the carbon world. Graphene modification and nanocomposite formation have been used to expand the practical potential of graphene nanostructure. The overview is an effort to highlight the indispensable synthesis strategies towards the formation of graphene nanocomposites. Consequently, graphene has been combined with useful matrices (thermoplastic, conducting, or others) to attain the desired end material. Common fabrication approaches like the in-situ method, solution processing, and melt extrusion have been widely involved to form the graphene nanocomposites. Moreover, advanced, sophisticated methods such as three- or four-dimensional printing, electrospinning, and others have been used to synthesize the graphene nanocomposites. The focus of all synthesis strategies has remained on the standardized graphene dispersion, physical properties, and applications. However, continuous future efforts are required to resolve the challenges in synthesis strategies and optimization of the parameters behind each technique. As the graphene nanocomposite design and properties directly depend upon the fabrication techniques used, there is an obvious need for the development of advanced methods having better control over process parameters. Here, the main challenging factors may involve the precise parameter control of the advanced techniques used for graphene nanocomposite manufacturing. Hence, there is not only a need for current and future research to resolve the field challenges related to material fabrication, but also reporting compiled review articles can be useful for interested field researchers towards challenge solving and future developments in graphene manufacturing.