Introduction: the presence of anti-CCP is an important prognostic tool for rheumatoid arthritis (RA), but its relationship with the activity of the disease and functional capacity is still being investigated. Objectives: to study the relationship between anti-CCP and the indices of disease activity, functional capacity and structural damage, by means of conventional radiography (CR) and magnetic resonance imaging (MRI), in stabilized RA. Methods: cross-sectional study of RA patients with one to 10 years of disease. The participants were subjected to clinical evaluation with anti-CCP screening. Disease activity was assessed by means of the Clinical Disease Activity Index (CDAI) and functional capacity by means of the Health Assessment Questionnaire (HAQ). CR was analyzed by the Sharp van der Heijde index (SmvH) and MRI by the Rheumatoid Arthritis Magnetic Resonance Image Scoring System (RAMRIS). Results: 56 patients were evaluated, with median (IIq) of 55 (47.5–60.0) years, 50 (89.3%) were female among whom 37 (66.1%) were positive for anti-CCP. The median (IIq) of CDAI, HAQ, SmvH and RAMRIS were 14.75 (5.42–24.97), 1.06 (0.28–1.75), 2 (0–8) and 15 (7–35), respectively. There was no association between anti-CCP and CDAI, HAQ, SmvH and RAMRIS. Conclusion: our results did not establish the association of anti-CCP with the severity of the disease. So far, we cannot corroborate the anti-CCP as a prognostic tool in RA established.

In order to seek management alternatives for anthracnose caused by the fungus Colletotrichum gloeosporioides in blackberry (Rubus glaucus Benth.), at the Tibaitatá Research Center of the Colombian Agricultural Research Corporation AGROSAVIA (formerly CORPOICA), an experiment was conducted to evaluate the effect of the application of the major elements nitrogen (N), phosphorus (P), potassium (K) and calcium (Ca) on infections of the fungus C. gloeosporioides strain-52. For this purpose, a randomized complete block design was used with an arrangement of treatments in an orthogonal central composite design. To evaluate the relationship of fertilization levels and disease severity, an artificial inoculation was made on thorny blackberry stems using 0.5 cm mycelial discs at a concentration of 9.53 × 104 conidia. Observations consisted of: disease severity (S), incubation period (IP) and rate of development (r). Data analysis was done by the cluster method on the severity variable, a Pearson correlation analysis between variables, as well as a regression to estimate the effect of nutrients applied on the severity of C. gloeosporioides strain-52. The treatments were concentrated in four groups with the ranges (in parentheses) S (15.9% and 91.8%), PI (9 and 15.3) and Tr (0.0254 and 0.0468). A positive and significant correlation was observed between S and r (P < 0.001) and a negative correlation between PI with S and r (P < 0.001). By means of regression analysis, a linear model was generated that showed a reduction in disease severity with increasing N dose and an increase with the levels of P and Ca applied.

We analyzed the relationship between nutrient (N and K) parceling and population density on the severity of onion downy mildew under no-tillage fertigation cultivation in the conditions of Alto Vale do Itajaí (Barzil). For this purpose, field trials were conducted in the years 2017, 2018 and 2019, in Ituporanga (Barzil). The treatments corresponded to four population densities (300, 400, 500 and 600 mil plants ha^-1) subjected to applications of nitrogen (150 kg N ha^-1) and potassium (127.5 kg K₂O ha^-1) distributed throughout the vegetative cycle of the crop via fertigation on a weekly, biweekly and monthly basis, based on the absorption curve of these nutrients for the cultivar Empasc 352-Bola Precoce. In fertigated no-tillage systems, nutrient (N and K) tranches do not influence the severity of downy mildew. The severity of downy mildew increases linearly with increasing population density, especially from 500 mil plants per ha^-1.

This study addresses the impact of the tourism sector on poverty, poverty depth, and poverty severity in Indonesia, focusing on the micro-level dynamics in the province. Despite numerous tourism destinations, their strategic contribution to regional progress remains underexplored. The motivation stems from the need to comprehend the nuanced relationship between tourism and poverty at both the national and local levels, with specific attention to the untapped potential at the province level in Indonesia. We hypothesize that a higher tourism sector GRDP will be inversely correlated with poverty levels, and the inclusion of a Covid-19 variable will reveal a structural impact on poverty dynamics. Employing a Panel Regression Model, secondary data from the Central Statistics Agency (BPS) spanning 2011–2020 is utilized. A panel data regression equation model, including CEM, FEM, and REM, is employed to analyze the intricate relationship between tourism and poverty. The findings demonstrate a negative correlation between higher tourism sector GRDP and the number of poor people. The Covid-19 variable, considered a structural break, reveals a significant association between increased cases and elevated poverty and severity across Indonesian provinces. This study contributes a micro-level analysis of tourism’s role, emphasizing its impact at the provincial level. The findings underscore the need for strategic initiatives to harness the untapped potential of tourism in alleviating poverty and promoting regional progress.

During and after the Covid-19 outbreak, people’s precautionary measures of not visiting public venues like cinema halls or multiplexes were replaced by watching treasured videos or films in private settings. People are able to watch their favourite video contents on a variety of internet-connected gadgets thanks to advanced technologies. As a result, it appears that the Covid-19 outbreak has had a substantial impact on people’s inclination to continue using video streaming services. This study attempted to establish an integrated framework that describes how people change their health behaviours during pandemic conditions using the health belief model (HBM), as well as the mediating effect of HBM constructs over ECM constructs such as continuous intention to subscribe to OTT video streaming services among subscribers. The study looked at the impact of three perceived constructs, susceptibility, severity, and self-efficacy, on the confirmation/adoption of over-the-top (OTT) video streaming services during the lethal pandemic (Covid-19). The study focused on new OTT video streaming service subscribers, and 473 valid replies were collected. Path analysis and multivariate analytical methods, such as structural equation modelling (SEM), were used to estimate construct linkages in the integrated framework. Perceived severity has been identified as the most influential factor in confirmation/adoption, followed by perceived susceptibility. The results also showed that satisfied users/subscribers are more likely to use OTT video streaming services. The mediators, confirmation/adoption, perceived usefulness, and satisfaction were used to validate the influence of perceived susceptibility on continuance intention. Furthermore, contactless entertainment enhances security for users/subscribers by allowing them to be amused across several internet-based venues while adhering to social distance norms.