Vocational education undergraduate applied chemistry major is of great significance in cultivating applied talents, however, the traditional curriculum and teaching mode can no longer fully meet the needs of students and the requirements of the industry. In order to improve students’ practical ability, innovation ability and application ability to meet the industry demand and improve students’ employment competitiveness, the curriculum construction of VET undergraduate applied chemistry major needs to be explored and considered. Taking the curriculum construction of VET undergraduate applied chemistry major as an entry point, this paper analyzes the challenges and problems faced in this field and puts forward a series of strategies and reflections.