Taxus cuspidata Sieb. ET. Zucc. is a taxus of Taxaceae, a rare third-order relict species distributed in northeastern China, and a wild endangered plant species protected by national level I. Taxol (paclitaxel, trade name taxol) and cephalomannine (cephalomannine) are all diterpenoids contained in the genus Taxus, with broad-spectrum anti-tumor activity and unique anti-cancer mechanism. In this study, the distribution of paclitaxel and cephalomannine in the leaves of Taxus cuspidata in different parts and different growth stages was discussed. The results showed that the content of two substances in the leaves of the majority of the crowns was lower than that of the biennial and tertiary there were no significant differences in the contents of two substances in the two-year and three-year-old

foliage. There was no significant difference in the contents of the two layers in the three levels of the noodles, and

the content of the male was slightly higher than that of the dark. The content of paclitaxel in the leaves of natural

northeast yew was the highest at dormancy period, and the content of flowering and fruit was not much different. The

content of Cephalotaxin was the highest in dormancy period, and that of cephalosporin the content of paclitaxel and

cephalomannine in each plant were significantly different. There was significant difference between the two plants.

The characteristics of agricultural products are influenced by the ecosystem, from the perspective of biotic and abiotic factors, which produce in the plant physiological responses and in turn in the fruit unique physicochemical properties, which are the basis for designations of origin and strategies to add value to the product in the current market. In the present work, ten cocoa materials (Theobroma cacao L.) were selected for their outstanding productivity (FSV41, FLE3, FEAR5, FSA12, FEC2, SCC23, SCC80, SCC55, ICS95 and CCN51), which were established in the departments of Santander (931 m a.s.l.), Huila (931 m a.s.l.), Huila (931 m a.s.l.), Huila (931 m a.s.l.), Huila (931 m a.s.l.), Huila (931 m a.s.l.) and Huila (931 m a.s.l.). These were established in the departments of Santander (931 m a.s.l.), Huila (885 m a.s.l.) and Arauca (204 m a.s.l.), the main cocoa-producing areas in Colombia. For the evaluation of the physical characteristics of the collected materials, 21 quantitative descriptors were used to determine the physical variability of the fruit according to clone and place of collection. The data collected were analyzed by means of Pearson’s correlation matrix and principal component analysis, it was possible to identify those descriptors that contribute most to the variability among materials (ear index, diameter length ratio, seed weight and diameter, and fruit weight and length). In addition, it was possible to verify the effect of the place of harvest on the physical characteristics of the materials, high-lighting the importance of the adaptation study prior to the planting of the cocoa material, with the objective of guaranteeing a premium, productive and quality cocoa crop for the industry, which is competitive in the market.

The H3N2 influenza virus is spiking dramatically, which is a major concern worldwide and in India. The multifunctional hetero-trimer influenza virus RNA-dependent RNA polymerase (RdRP) is involved in the generation of viral mRNA and is crucial for viral infectivity, which is directly related to the virus’s ability to survive. The goal of the current work was to use molecular docking to determine how the RdRP protein might be affected by powerful bioactive chemicals found in Calotropis gigantia latex. By applying CB-dock 2 analysis and 2D interactions, an in-silico docking study was conducted using a GC-FID (gas chromatography with flame-ionization detection) based composition profile. Tocospiro A (15%), Amyrin (7%), and Gombasterol A were found by GC-FID to be the main phytocompounds in the latex of Calotropis gigantia. The docking result showed that ligands were effectively bound to RdRP. According to interaction studies, RdRP/ligand complexes create hydrogen bonds, van der Waals forces, pi-alkyl bonds, alkyl bonds, and pi-Sigma bonds. Therefore, it was suggested that Calotropis gigantia latex may represent a possible herbal remedy to attenuate H3N2 infections based on the above findings of the fragrance profile and docking.

The aim of the research is to elucidate the features of the modern model of bioecomedicine and its components as a social determinant of sustainable societal development. The theoretical-methodological basis of the work was the complex use of scientific principles and a systematic approach, which determined the choice of research methods: general scientific and interdisciplinary. The concept generalized content is substantiated and the main lines of building the bioecomedicine model are characterized from the standpoint of information-structural modeling and sustainable development. Based on the structural-logical imperative, the object, subject, basic method and main concepts of this science sphere are characterized. The bioecomedicine principal idea as a social determinant of the sustainable development within a single information space is the unification of the knowledge information field of biology, ecology and medicine based on the use of the latest achievements in information technologies. It is proven that the algorithm for achieving the bioecomedicine global goal in the form of a set of principles reflects the essence of a systemic approach to solving the tasks of sustainable societal development by ensuring the system-environmental homeostasis of humans and the ecosystems that surround them.

This study aims to evaluate theories and ideas about social values and determine the high quality of virtues that potentially change social practices, thinking, self-awareness, and behavior of the individual and society. The relevance of the study of value components is determined by the fact that such values as “spirituality and morality”, “responsibility”, “justice”, “rationality”, and “security” are capable of capturing the greatest value of many interests, which allows for the integration of society. An experimental study was conducted using sociological research methods based on developed questionnaires with questions touching on the parameters of sustainable development of society, determining the high quality of virtues and behavior of the individual and society. The study was conducted from May to June 2023 (N = 1387). Based on Demoethical values, special attention is paid to global problems related to climate change and inefficient use of energy and water resources, thereby achieving the Sustainable Development Goals. As a result of the study, Demoethical values are revealed in interaction with the economic components of demography, democracy, and demoeconomics as a tool for social transformation, as they shape the harmonious vision of the world, human behavior, decisions, and relationships with other people.

This study explored the competencies required for informal community leaders to effectively promote health within Thai communities, employing an exploratory sequential mixed-methods design. The qualitative phase, comprising in-depth interviews with thirteen community leaders, identified four critical domains of competency: basic health knowledge, communication skills, network building, and cultural awareness. These domains were subsequently validated through second-order confirmatory factor analysis, which confirmed their reliability and construct validity. The findings highlighted the pivotal role of these competencies in enabling community-led health promotion initiatives. This research provides a robust, evidence-based framework to inform the development of training programs, policy strategies, and targeted interventions aimed at enhancing health outcomes within Thai communities.