E-cigarettes pose a significant public health concern, particularly for youth and young adults. Policymaking in this area is complicated by changing consumption patterns, diverse user demographics, and dynamic online and offline communities. This study uses social network analytics to examine the social dynamics and communication patterns related to e-cigarette use. We analyzed data from various social media platforms, forums, and online communities, which included both advocacy for e-cigarettes as a safer smoking alternative and opposition due to health risks. Our findings inform targeted healthcare policy interventions, such as educational campaigns tailored to specific network clusters, regulations based on user interaction and influence patterns, and collaborations with key influencers to spread accurate health information.