This paper presents a coupling of the Monte Carlo method with computational fluid dynamics (CFD) to analyze the flow channel design of an irradiated target through numerical simulations. A novel series flow channel configuration is proposed, which effectively facilitates the removal of heat generated by high-power irradiation from the target without necessitating an increase in the cooling water flow rate. The research assesses the performance of both parallel and serial cooling channels within the target, revealing that, when subjected to equivalent cooling water flow rates, the maximum temperature observed in the target employing the serial channel configuration is lower. This reduction in temperature is ascribed to the accelerated flow of cooling water within the serial channel, which subsequently elevates both the Reynolds number and the Nusselt number, leading to enhanced heat transfer efficiency. Furthermore, the maximum temperature is observed to occur further downstream, thereby circumventing areas of peak heat generation. This phenomenon arises because the cooling water traverses the target plates with the highest internal heat generation at a lower temperature when the flow channels are arranged in series, optimizing the cooling effect on these targets. However, it is crucial to note that the pressure loss associated with the serial structure is two orders of magnitude greater than that of the parallel structure, necessitating increased pump power and imposing stricter requirements on the target container and cooling water pipeline. These findings can serve as a reference for the design of the cooling channels in the target station system, particularly in light of the anticipated increase in beam power during the second phase of the China Spallation Neutron Source (CSNS Ⅱ).

COVID-19 pandemic has caused many design bid build projects to suffer losses. Design bid build or DBB has the disadvantage of depth partnering. The research purpose is to reveal the depth of partnering of DBB, the characteristics of existing partnering in DBB through detection in each project life cycle in DBB, then efforts to increase DBB partnering to partnering in integrated project delivery (IPD). The methodology used is secondary data from three project DBB, then validation using focused group discussions (FGD) with expert judgment, then the Delphi method to analyse and propose recommendations. This project recommends that DBB project can improve the project performance so stakeholder can increase partnering toward integrated project delivery (IPD) partnering. This research can be used for increasing partnering in DBB projects towards partnering in IPD. This research will produce strategic recommendations that can be utilized by stakeholders (owner, contractor, designer) in improving project performance to generate great value for the project, will result in long-term project sustainability, improve relationships, and learn valuable lessons for future projects. DBB projects usually experience many problems due to the competitive nature of partnering for owners, contractors, and designers, so it is necessary to develop an overall strategy as an option to improve partnering in DBB project contracts. This research will help create a sustainable project by the owner, contractor, and designer.

Objective: Standardizing image acquisition protocols and image quality across cameras is an important need in imaging, in particular in multi-center clinical trials and the use of image analysis and machine learning algorithms. The objective of this study was to examine the effect of ordered subset expectation maximization (OSEM) reconstruction parameters on the quantitative image quality of cardiac perfusion SPECT images in different typical SPECT cameras and therefore assess the need to change the parameter values across cameras. Methods: The analysis was carried out by comparing the defect contrast-to-noise ratio (CNR) at 12 OSEM subset-iteration combinations. Eight frames were reconstructed using the SIMIND Monte Carlo Simulation package. An activity of 370 MBq (10mCi) and projection acquisition interval of 20 seconds per projection were used. Attenuation (AC) and scatter corrections (SC) were performed in this study for all images. Results: The 16-2 subset-iteration combination yielded the highest CNR and defect contrast values for both cameras. The difference between CNR values for two cameras was found to be close to 5%. Conclusions: Monte Carlo simulations can be useful to investigate how quantitative image quality behaves with respect to reconstruction parameters and correction algorithms in a controlled environment. In this study, the use of different camera brands did not seem to significantly affect the lesion detectability. Further simulations with more extended range of parameters and camera brands may be conducted in the future to quantify further the variability between different brands of cameras.

To achieve sustainable development, detailed planning, control and management of land cover changes that occur naturally or by human caused artificial factors, are essential. Urban managers and planners need a tool that represents them the information accurate, fast and in exact time. In this study, land use changes of 3 periods, 1994-2002, 2002-2009, 2009-2015 and predictions of 2009, 2015 and 2023 were assessed. In this paper, Maximum Likelihood method was used to classify the images, so that after evaluation of accuracy, amount of overall accuracy for images of 2013 was 85.55% and its Kappa coefficient was 80.03%. To predict land use changes, Markov-CA model was used after assessing the accuracy, and the amount of overall accuracy for 2009 was 82.57% and for 2015 was 93.865%. Then web GIS application was designed via map server application and evoked shape files through map file and open layers to browser environment and for design of appearance of website CSS, HTML and JavaScript languages were used. HTML is  responsible for creating the foundation and overall structure of webpage but beautifying and layout design on CSS. 

Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

With the implementation of the rural revitalization strategy, rural wisdom pension gradually becomes an important direction for the development of rural society. The purpose of this paper is to study the optimization path of rural smart pension in the context of rural revitalization. By analyzing the definition, development status and dilemma of rural wisdom pension, key factors for optimizing rural wisdom pension are proposed, and the paths for enhancing rural wisdom pension are discussed. The research results show that strengthening infrastructure construction, improving service quality, and promoting information technology application are the key paths to realize rural smart aging. This study provides theoretical guidance and policy recommendations for the implementation of rural smart aging.