Recent technological advances in the fields of biomaterials and tissue engineering have spurred interest in biopolymers for various biomedical applications. The advantage of biopolymers is their favorable characteristics for these applications, among which proteins are of particular importance. Proteins are explored widely for 3D bioprinting and tissue engineering applications, wound healing, drug delivery systems, implants, etc., and the proteins mainly available include collagen, gelatin, albumin, zein, etc. Zein is a plant protein abundantly present in corn endosperm, and it is about 80% of total corn protein. It is a highly renewable source, and zein has been reported to be applicable in different industrial applications. Lately, it has gained attention in biomedical applications. This research interest in zein is on account of its biocompatibility, non-toxicity, and certain unique physico-chemical properties. Zein comes under the GRAS category and is considered safe for biomedical applications. The hydrophobic nature of this protein gives it an added advantage and has wider applications in drug delivery. This review focuses on details about zein protein, its properties, and potential applications in biomedical sectors.
Graphene and derivatives have been frequently used to form advanced nanocomposites. A very significant utilization of polymer/graphene nanocomposite was found in the membrane sector. The up-to-date overview essentially highlights the design, features, and advanced functions of graphene nanocomposite membranes towards gas separations. In this concern, pristine thin layer graphene as well as graphene nanocomposites with poly(dimethyl siloxane), polysulfone, poly(methyl methacrylate), polyimide, and other matrices have been perceived as gas separation membranes. In these membranes, the graphene dispersion and interaction with polymers through applying the appropriate processing techniques have led to optimum porosity, pore sizes, and pore distribution, i.e., suitable for selective separation of gaseous molecules. Consequently, the graphene-derived nanocomposites brought about numerous revolutions in high-performance gas separation membranes. The structural diversity of polymer/graphene nanocomposites has facilitated the membrane selective separation, permeation, and barrier processes, especially in the separation of desired gaseous molecules, ions, and contaminants. Future research on the innovative nanoporous graphene-based membrane can overcome design/performance-related challenging factors for technical utilizations.
Researchers from all over the world have been working tirelessly to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic since the World Health Organization (WHO) proclaimed it to be a pandemic in 2019. Expanding testing capacities, creating efficient medications, and creating safe and efficient COVID-19 (SARS CoV-2) vaccinations that provide the human body with long-lasting protection are a few tactics that need to be investigated. In clinical studies, drug delivery techniques, including nanoparticles, have been used since the early 1990s. Since then, as technology has advanced and the need for improved medication delivery has increased, the field of nanomedicine has recently seen significant development. PNPs, or polymeric nanoparticles, are solid particles or particulate dispersions that range in size from 10 to 1000 nm, and their ability to efficiently deliver therapeutics to specific targets makes them ideal drug carriers. This review article discusses the many polymeric nanoparticle (PNP) platforms developed to counteract the recent COVID-19 pandemic-related severe acute respiratory syndrome coronavirus (SARS-CoV-2). The primary subjects of this article are the size, shape, cytotoxicity, and release mechanism of each nanoparticle. The two kinds of preparation methods in the synthesis of polymeric nanoparticles have been discussed: the first group uses premade polymers, while the other group depends on the direct polymerization of monomers. A few of the PNPs that have been utilized to combat previous viral outbreaks against SARS-CoV-2 are also covered.
A systemic and synthetic review of the anatomy of the temporomandibular joint in magnetic resonance imaging was developed for its evaluation. The temporomandibular joint is an anatomical structure composed of bones, muscles, ligaments and an articular disc that allows important physiological movements, such as mandibular opening, closing, protrusion, retrusion and lateralization. Magnetic resonance imaging is an imaging technique that does not use ionizing radiation and is more specific for the evaluation and interpretation of soft tissues, due to its high resolution, so it has an important role in the diagnosis of various maxillofacial pathologies, which is why the dentist should have knowledge of the structures and functions of the temporomandibular joint through magnetic resonance imaging. The review demonstrates the importance of magnetic resonance imaging in the study of the anatomy of the temporomandibular joint, in addition to mentioning the advantages provided by this imaging technique such as its good detail of the soft tissues in its different sequences and the non-use of ionizing radiation to obtain its images.
This research paper aims to explore the issue of university dropouts in Greece, which has become a growing concern in recent years due to its impact on individuals, educational institutions, and society as a whole. One of the main contributing factors to students discontinuing their higher education in Greece is the choice of the wrong faculty. Financial challenges, unrelated to tuition fees, also significantly affect students’ ability to pursue their studies. Family background plays a crucial role, with students from families with higher educational attainment exhibiting greater persistence. The study found that gender, age, and academic performance can influence students’ perceptions of dropout factors, which can change as they progress through their educational journey. To address these challenges, the research proposes a multifaceted approach, including early intervention programs, expanded financial support, improved mental health and counseling services, flexible learning options, and strong academic advising.
Local scour, a complex phenomenon in river flows around piers with movable beds, can damage bridge piers during high floods. Predicting scour depth accurately is vital for safety and economic reasons, especially for large bridges. This study using hydraulic flume laboratory experiments compared diamond, square, and elliptical pier models of different sizes under steady clear-water conditions considering different flow rates and discharge levels to identify the most efficient shape with less local scour. Local scour, a complex phenomenon in three-dimensional flow around piers in rivers with movable beds, can lead to detrimental effects on bridge piers due to high flood velocities. Accurate prediction of scour depth is crucial for economic and safety reasons, especially for large bridges with complex piers. Hydraulic engineers are keen on forecasting the equilibrium scour depth. To achieve this, laboratory testing compared diamond, square, and elliptical pier models under steady clear-water conditions to identify the most efficient pier shape with less local scour. This research provides valuable insights for optimizing pier design to enhance bridge stability and resilience against scour-induced risks. A variety of configurations, including different sizes and shapes of piers were experimented with in the flume using diamond, square, and elliptical shapes. The test results showed that the local scour depth around elliptical piers was around 29.16% less, and around diamond piers, it was approximately 16.05% less compared to the scour depth observed around square piers with the same dimensions. The researchers also observed distinct patterns of scouring around different pier shapes. Specifically, the square-shaped piers displayed the highest level of scouring depth, that is, 48 mm, followed by the diamond-shaped pier which experienced a scouring depth of 48 mm while the elliptical-shaped piers experienced the least amount of scouring depth, that is, 34 mm. The test results also demonstrated that pier size significantly influences scouring, with an increase in pier size from 3 × 3 cm2 to 5 × 5 cm2 leading to a rise in scour depth by 26.04%. Moreover, this study findings also elucidated that an increase in flow results in an increase of in scouring depth i.e., elevating the discharge from 0.0026 cumecs to 0.0029 cumecs led to a 28.13% increase in scouring depth for the identical pier size. These findings provide valuable insights into the hydraulic behavior of various pier shapes and can aid in the optimization of bridge design and hydraulic engineering practices. The investigations further revealed that local scouring is sensitive not only to pier dimensions but also to other critical parameters, including flow rate, time of exposure, and the size of a pier.
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