In the last several decades, cardiovascular diseases (CVDs) have emerged as a major hazard to human life and health. Conventional formulations for the treatment of CVD are available, but they are far from ideal because of poor water solubility, limited biological activity, non-targeting, and drug resistance. With the advancement of nanotechnology, a novel drug delivery approach for the treatment of CVDs has emerged: nano-drug delivery systems (NDDSs). NDDSs have shown significant advantages in tackling the difficulties listed above. Cytotoxicity is a difficulty with the use of non-destructive DNA sequences. NDDS categories and targeted tactics were outlined, as well as current research advancements in the diagnosis and treatment of CVDs. It’s possible that gene therapy might be included into nano-carriers in the delivery of cardiovascular medications in the future. In addition, the evaluation addressed the drug’s safety.

Manuscript type: Research paper. Research aims: This study aims to explore the determinants of voluntary IFRS application in listed firms in Vietnam. Design/methodology/approach: Analyzing data from 552 public companies listed on the Ho Chi Minh Stock Exchange and Ha Noi Stock Exchange during 2019–2022, this study employs a logistic model with robust analysis. Research findings: The findings indicate that voluntary IFRS application is positively associated with firm size, leverage, internationalization, corporate efficiency, state ownership, and foreign ownership. Particularly, internationalization has the most significant impact on voluntary IFRS application. Theoretical contribution/originality: These findings of this study align with positive accounting theory, which proposes how factors affect voluntary IFRS application. Practitioner/policy implications: Policymakers should consider these findings when developing or revising policies concerning voluntary IFRS application, particularly for state-owned and foreign-owned companies. Research limitation: This study spans from 2019 to 2022, during which economic and regulatory conditions may have fluctuated, potentially impacting the results. Moreover, the data on voluntary IFRS adoption were collected through surveys, which may be subject to respondent bias and dependent on participants’ understanding and willingness to provide accurate information.

The effective allocation of resources within police patrol departments is crucial for maintaining public safety and operational efficiency. Traditional methods often fail to account for uncertainties and variabilities in police operations, such as fluctuating crime rates and dynamic response requirements. This study introduces a fuzzy multi-state network (FMSN) model to evaluate the reliability of resource allocation in police patrol departments. The model captures the complexities and uncertainties of patrol operations using fuzzy logic, providing a nuanced assessment of system reliability. Virtual data were generated to simulate various patrol scenarios. The model’s performance was analyzed under different configurations and parameter settings. Results show that resource sharing and redundancy significantly enhance system reliability. Sensitivity analysis highlights critical factors affecting reliability, offering valuable insights for optimizing resource management strategies in police organizations. This research provides a robust framework for improving the effectiveness and efficiency of police patrol operations under conditions of uncertainty.

Carbon-based hollow structured nanomaterials have become one of the hot areas for research and development of hollow structured nanomaterials due to their unique structure, excellent physicochemical properties and promising applications. The design and synthesis of novel carbon-based hollow structured nanomaterials are of great scientific significance and wide application value. The recent research on the synthesis, structure and functionalization of carbon-based hollow structured nanomaterials and their related applications are reviewed. The basic synthetic strategies of carbon-based hollow structure nanomaterials are briefly introduced, and the structural design, material functionalization and main applications of carbon-based hollow structure nanomaterials are described in detail. Finally, the current challenges and opportunities in the synthesis and application of carbon-based hollow structured nanomaterials are discussed.

The Method of Discretization in Time (MDT) is a hybrid numerical technique intended to alleviate upfront the computational procedure of timedependent partial differential equations of parabolic type upfront. The MDT engenders a sequence of adjoint second order ordinary differential equations, wherein the space coordinate is the independent variable and time becomes an embedded parameter. Essentially, the adjoint second order ordinary differential equations are considered of “quasistationary” nature. In this work, the MDT is used for the analysis of unsteady heat conduction in regular bodies (large wall, long cylinder and sphere) accounting for nearly constant thermophysical properties, uniform initial temperature and surface heat flux. In engineering applications, the surface heat flux is customarily provided by electrical heating, radiative heating and pool fire heating. It is demonstrated that the approximate, semianalytical temperature solutions of the first adjoint “quasistationary” heat conduction equations using the first time jump are easily obtainable for each regular body. For enhanced acccuracy, regression analysis is applied to the deviations of the dimensionless surface temperature as a function of the dimensionless time for each regular body.

Humic substances are used in agriculture as promoters of plant growth, especially of the root system. The objective of the work was to evaluate the effect of the application of different doses of fulvic acid on the growth and productivity of American lettuce, Raider Plus cultivar. The experimental design used was entirely randomized, with five treatments of fulvic acid 0, 1, 2, 4, 8 mL·L^-1 and four repetitions, applied at the time of transplanting. Two experiments were conducted simultaneously: one in the greenhouse, where fresh and dry mass of the aboveground and root parts, length and volume of the roots were evaluated; and the other in the field, where, at the end of the cycle, fresh and dry mass of the aboveground parts, number of leaves, stem length and average head circumference were evaluated. The application of different doses of fulvic acid promoted the growth of lettuce plants, especially the root system. The emission of roots, with predominance, of those of smaller diameter, was found in the higher concentrations of fulvic acid. The number of leaves and the average circumference of the head expressed responses in the concentrations of fulvic acid.