Artificial intelligence chatbots can be used to conduct research effectively and efficiently in the fifth industrial revolution. Artificial intelligence chatbots are software applications that utilize artificial intelligence technologies to assist researchers in various aspects of the research process. These chatbots are specifically designed to understand researchers’ inquiries, provide relevant information, and perform tasks related to data collection, analysis, literature review, collaboration, and more. The purpose of this study is to investigate the use of artificial intelligence chatbots for conducting research in the fifth industrial revolution. This qualitative study adopts content analysis as its research methodology, which is grounded in literature review incorporating insights from the researchers’ experiences with utilizing artificial intelligence. The findings reveal that researchers can use artificial intelligence chatbots to produce quality research. Researchers are exposed to various types of artificial intelligence chatbots that can be used to conduct research. Examples are information chatbots, question and answer chatbots, survey chatbots, conversational agents, peer review chatbots, personalised learning chatbots and language translation chatbots. Artificial intelligence chatbots can be used to perform functions such as literature review, data collection, writing assistance and peer review assistance. However, artificial intelligence chatbots can be biased, lack data privacy and security, limited in creativity and critical thinking. Researchers must be transparent and take in consideration issues of informed content and data privacy and security when using artificial intelligence chatbots. The study recommends a framework on artificial intelligence chatbots researchers can use to conduct research in the fifth industrial revolution.

The fast-growing field of nanotheranostics is revolutionizing cancer treatment by allowing for precise diagnosis and targeted therapy at the cellular and molecular levels. These nanoscale platforms provide considerable benefits in oncology, including improved disease and therapy specificity, lower systemic toxicity, and real-time monitoring of therapeutic outcomes. However, nanoparticles' complicated interactions with biological systems, notably the immune system, present significant obstacles for clinical translation. While certain nanoparticles can elicit favorable anti-tumor immune responses, others cause immunotoxicity, including complement activation-related pseudoallergy (CARPA), cytokine storms, chronic inflammation, and organ damage. Traditional toxicity evaluation approaches are frequently time-consuming, expensive, and insufficient to capture these intricate nanoparticle-biological interactions. Artificial intelligence (AI) and machine learning (ML) have emerged as transformational solutions to these problems. This paper summarizes current achievements in nanotheranostics for cancer, delves into the causes of nanoparticle-induced immunotoxicity, and demonstrates how AI/ML may help anticipate and create safer nanoparticles. Integrating AI/ML with modern computational approaches allows for the detection of potentially dangerous nanoparticle qualities, guides the optimization of physicochemical features, and speeds up the development of immune-compatible nanotheranostics suited to individual patients. The combination of nanotechnology with AI/ML has the potential to completely realize the therapeutic promise of nanotheranostics while assuring patient safety in the age of precision medicine.