The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

This research examines data from 1989 to 2022 across 48 Sub-Saharan African (SSA) countries using a novel panel data regression approach to uncover how conflict undermines economic stability. The study identifies the destruction of infrastructure, disruption of human capital development, and deterrence of investment as primary channels through which conflict negatively impacts economies. These findings support the hypothesis that armed conflict severely hampers economic performance in SSA, highlighting the urgency for effective conflict resolution strategies and robust institutional frameworks. The negative impacts extend beyond immediate losses, altering income growth trajectories and perpetuating poverty long after hostilities cease. Regional spillover effects emphasize the interconnectedness of SSA economies, where conflict in one country affects its neighbors. The research provides innovative insights by disaggregating impact pathways and employing a robust methodology, revealing the complexity of conflict's economic consequences. It underscores the need for comprehensive policy interventions to foster resilience and sustainable development in conflict-prone regions. While there is evidence of potential post-conflict growth, the overall net effect of armed conflict remains profoundly negative, diminishing economic prospects. Future research should focus on strengthening long-term resilience mechanisms and policy measures to enhance the peace dividend. Addressing the root causes of conflict and investing in peace-building efforts are essential for transforming SSA's economic landscape and ensuring sustainable growth and development.

In today's changing world of work, Strategic Human Resource Management (SHRM)) still focuses on making workers more productive. This study systematically examines the mediating function of incentives both monetary and non-monetary between antecedent characteristics (e.g., leadership, organizational culture) and employee productivity using a systematic literature review (SLR) of papers published from 2010 to 2024. The review adheres to PRISMA principles and integrates 18 peer-reviewed studies chosen through a stringent screening and quality evaluation process from Scopus and Google Scholar. The results show that the success of incentives depends a lot on things like the ideals of the business, the style of leadership, and the demographics of the workforce. Thematic analysis, informed by the Ability-Motivation-Opportunity (AMO) theory and Strategic Human Resource Management (SHRM) frameworks, delineates four principal processes by which incentives affect productivity: goal alignment, perceived equity, motivational pathways, and cultural congruence. The research emphasizes the necessity of customizing incentive systems to specific organizational contexts and offers practical guidance for HR professionals. Recognizing limitations and publishing bias, suggestions for future incentive system design are presented.

In the new century, the traditional model of enterprise human resource management is facing the challenge of the times, improving the human resource management of enterprises, and must innovate the concept of enterprise human resource management. After the 1950s, some economists established the theory of human capital, not only can more effectively explain the problems of modern social economic growth, but also on the enterprise's human resources management contribution to a positive impact. This paper introduces the concept of human capital and human capital investment into enterprise human resource management, which opens up a new perspective for enterprise human resource management. In this paper, we will first define the characteristics of human capital and the main body of human capital investment, and then analyze the meaning of various human resource management behaviors from the perspective of capital investment, estimate their benefits, costs and risks, and finally use scientific means to establish investment decision model and risk control mechanism, to maximize the effectiveness of human resources, so that the management behavior of enterprise's human can bring more revenue for the enterprises, thereby enhancing the competitiveness of enterprises. At present, the scientific operation of human resources is the key to the healthy development of enterprises.

Disinformation can be defined as false information deliberately initiated to cause harm to a person, social group, organization, or country. Gendered disinformation then attacks or undermines people based on gender or weaponizes gendered narratives for political, social, or economic objectives. Gendered disinformation comes in different forms, such as harmful social media posts and graphics, sexual fabrications, and other forms of conspiracy theories. It is used in various situations and at different places. This research discussed the instances of gendered disinformation and harmful online narratives that are recognizable and visible. It sheds light on the potential direct and indirect impact on youth experiences. In this study, the young participants (aged 18–30) focused on the instances of the existing online narratives of gendered discrimination from Belgium, Greece, Latvia, Spain, and Türkiye. The research provided an initial analysis of what “gendered information and harmful online narratives” look like and some recommendations from youth perspectives on countering the issues. The study concluded that there is a need for more research, further harmonization of legal frameworks, and strengthened capacity to detect gendered disinformation, propaganda, and hate speech.

The current manuscript overviews the potential of inimitable zero dimensional carbon nanoentities, i.e., nanodiamonds, in the form of hybrid nanostructures with allied nanocarbons such as graphene and carbon nanotube. Accordingly, two major categories of hybrid nanodiamond nanoadditives have been examined for nanocompositing, including nanodiamond-graphene or nanodiamond/graphene oxide and nanodiamond/carbon nanotubes. These exceptional nanodiamond derived bifunctional nanocarbon nanostructures depicted valuable structural and physical attributes (morphology, electrical, mechanical, thermal, etc.) owing to the combination of intrinsic features of nanodiamonds with other nanocarbons. Consequently, as per literature reported so far, noteworthy multifunctional hybrid nanodiamond-graphene, nanodiamond/graphene oxide, and nanodiamond/carbon nanotube nanoadditives have been argued for characteristics and potential advantages. Particularly, these nanodiamond derived hybrid nanoparticles based nanomaterials seem deployable in the fields of electromagnetic radiation shielding, electronic devices like field effect transistors, energy storing maneuvers namely supercapacitors, and biomedical utilizations for wound healing, tissue engineering, biosensing, etc. Nonetheless, restricted research traced up till now on hybrid nanodiamond-graphene and nanodiamond/carbon nanotube based nanocomposites, therefore, future research appears necessary for further precise design varieties, large scale processing, and advanced technological progresses.