Background: Multiple sclerosis is often a longitudinal disease continuum with an initial relapsing-remitting phase (RRMS) and later secondary progression (SPMS). Most currently approved therapies are not sufficiently effective in SPMS. Early detection of SPMS conversion is therefore critical for therapy selection. Important decision-making tools may include testing of partial cognitive performance and magnetic resonance imaging (MRI). Aim of the work: To demonstrate the importance of cognitive testing and MRI for the prediction and detection of SPMS conversion. Elaboration of strategies for follow-up and therapy management in practice, especially in outpatient care. Material and methods: Review based on an unsystematic literature search. Results: Standardized cognitive testing can be helpful for early SPMS diagnosis and facilitate progression assessment. Annual use of sensitive screening tests such as Symbol Digit Modalities Test (SDMT) and Brief Visual Memory Test-Revised (BVMT-R) or the Brief International Cognitive Assessment for MS (BICAMS) test battery is recommended. Persistent inflammatory activity on MRI in the first three years of disease and the presence of cortical lesions are predictive of SPMS conversion. Standardized MRI monitoring for features of progressive MS can support clinically and neurocognitively based suspicion of SPMS. Discussion: Interdisciplinary care of MS patients by clinically skilled neurologists, supported by neuropsychological testing and MRI, has a high value for SPMS prediction and diagnosis. The latter allows early conversion to appropriate therapies, as SPMS requires different interventions than RRMS. After drug switching, clinical, neuropsychological, and imaging vigilance allows stringent monitoring for neuroinflammatory and degenerative activity as well as treatment complications.

Introduction: the presence of anti-CCP is an important prognostic tool for rheumatoid arthritis (RA), but its relationship with the activity of the disease and functional capacity is still being investigated. Objectives: to study the relationship between anti-CCP and the indices of disease activity, functional capacity and structural damage, by means of conventional radiography (CR) and magnetic resonance imaging (MRI), in stabilized RA. Methods: cross-sectional study of RA patients with one to 10 years of disease. The participants were subjected to clinical evaluation with anti-CCP screening. Disease activity was assessed by means of the Clinical Disease Activity Index (CDAI) and functional capacity by means of the Health Assessment Questionnaire (HAQ). CR was analyzed by the Sharp van der Heijde index (SmvH) and MRI by the Rheumatoid Arthritis Magnetic Resonance Image Scoring System (RAMRIS). Results: 56 patients were evaluated, with median (IIq) of 55 (47.5–60.0) years, 50 (89.3%) were female among whom 37 (66.1%) were positive for anti-CCP. The median (IIq) of CDAI, HAQ, SmvH and RAMRIS were 14.75 (5.42–24.97), 1.06 (0.28–1.75), 2 (0–8) and 15 (7–35), respectively. There was no association between anti-CCP and CDAI, HAQ, SmvH and RAMRIS. Conclusion: our results did not establish the association of anti-CCP with the severity of the disease. So far, we cannot corroborate the anti-CCP as a prognostic tool in RA established.

Bioactive materials are those that cause a number of interactions at the biomaterial-living tissue inter-face that result in the evolution of a mechanically strong association between them. For this reason, an implantable material’s bioactive behavior is highly advantageous. Silicate glasses are encouraged to be used as bioactive glasses due to their great biocompatibility and beneficial biological effects. The sol-gel method is the most effective for preparing silicate glasses because it increases the material’s bioactivity by creating pores. Glass densities are altered by the internal network connectivity between network formers and network modifiers. The increase in the composition of alkali or alkaline oxides reduces the number of bridging oxygens and increases the number of non-bridging oxygens by retaining the overall charge neutrality between the alkali or alkaline cation and oxygen anion. Higher drying temperatures increase pore densities, while the melt-quenching approach encourages the creation of higher density glasses. Band assignments for the BAG structure can be explained in detail using Fourier Transform Infrared (FTIR) and Raman spectroscopic investigations. Raman spectroscopy makes it simple to measure the concentration of the non-bridging oxygens in the silica matrix.

This study aims to analyze, investigate the implications, and identify differences in the progress of the effect of institutional changes and organizational transformation in Indonesian higher education. The structuration analysis shows that examining the conditions that have resulted in the replication and modification of social systems is the focus of the structuration analysis. The image of structuration theory conveys both a sense of regularity and continuity, as well as respect for the labor that must be done daily and the mundane but essential tasks that must be completed. The finding of this study is that with the mandate that universities have been given to implement the three primary pillars that support Indonesia’s higher education system, the difficulty level of the problem facing Indonesia’s higher education system has increased. We suggest a future research agenda and highlight the changes and transformations in power, interests, and alliances that affect the evolution of higher education institutions.

Overwhelming studies unanimously agreed that preservation of the environment is a central climax in the discourse of green banking. There is a growing interest in exploring green banking practices for fostering financial inclusion, economic growth and sustainable development as part of Vision 2030 in Saudi Arabia. There are insufficient studies that examine this in the context of Saudi Arabia. This study aims at exploring the potential of green banking in order to attain sustainable banking and financial inclusion in achieving vision 2030in the country. Qualitative content analysis is used as a methodology of the study. Data were gathered through different sources such as: Web of Science (WOS), related journals, newspapers, published references, research papers, library sources and environmental organizations reports. It is indicated that green banking initiatives can be instrumental in fostering sustainable economic and environmental development in the Kingdom. The paper highlighted various activities of green banking such as: renewable and clean energy, financing green agriculture/food security, high-quality infrastructure among others. Nonetheless, some impediments to the green banking practices such as: risks facing green banks, poor quality of financial services among others are also mentioned in this paper. The paper proffers solutions to the challenges impeding green banking practices. In conclusion, the financial and banking industries in Saudi Arabia has been proving reform of the sector through greening economy. It is there suggested that the stakeholders and policymakers should provide efficient and effective technical, operational legal frameworks for enhancing green economy in achieving Vision 2030 in the country.

Online transportation is a new type of service equipped with an internet network, and its presence in Indonesia is considered a service that disrupts the transportation sector. The government is faced with a complex policy problem to regulate online transportation. This article aims to reveal the role of policy actors in the media regarding policy issues and online transportation policy solutions. This article used qualitative analysis and the NPF policy narrative framework approach. This study found that licensing issues and Permenhub were problems that the DIY and Riau governments shared. More specific problems in Riau Province are related to violence issues, and that in DIY are related to congestion problems. The policy solution recommended by policy actors to the media is to make regional level regulations that technically regulate online transportation according to the area conditions.