Atomic interaction between mediator protein of human prostate cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use molecular dynamics (MD) approach based on Newton’s formalism to describe the destruction of PHPC via Fe/C720 Buckyballs-Statin with atomic accuracy. In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by universal force field (UFF) and DREIDING force-field to introduce their time evolution. The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27 Å to 2.96 Å after 10 ns. Physically, these interactions causing the destruction of the PHPC. Numerically, the volume of this biostructure enlarged from 665,276 Å3 to 737,143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry. Simulations indicated the volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.
The United Nations General Assembly declared 2023 the “International Year of Millets” in order to promote millet cultivation, consumption, and conservation. Millets play an important role in food security, livelihoods, and biodiversity. Despite its numerous benefits, millet cultivation and consumption in Uttarakhand have declined due to a variety of constraints. This paper examines the effects of regiocentrism and materialism on intention towards Uttarakhand’s regional food products (millets). It employs PLS-SEM to investigate relationships between latent variables and generate results on a sample of 460 participants. This study elucidates the intricate interplay between materialism, regiocentrism, and intention towards regional food products in the Himalayan region, enriching the theory of planned behavior (TPB) with a nuanced understanding of personal values and regional identity. It reveals materialism’s positive association with attitudes towards regional food products, suggesting materialistic individuals may view these products as status symbols, thus affecting behavioral intentions. Additionally, the research highlights regiocentrism’s dual influence—enhancing attitudes yet deterring purchase intentions—underscoring the complexity of regional pride in consumer decision-making. These findings advance TPB by integrating broader value systems and cultural context, offering significant theoretical and practical insights for promoting sustainable consumption patterns.
Based on digital technology, the digital economy has typical characteristics of high efficiency, greenness, intelligence, innovation, strong penetration and so on, which can promote the sporting goods manufacturing industry (SGMI) to realize the goal of green development. This study selects panel data from 30 provinces in China over the period of 2011 to 2022. And the green total factor productivity of the sporting goods manufacturing industry (SGTFP) is used to reflect the green development of SGMI. The level of digital economy development (DIG) and the SGTFP are measured by using the entropy method and the Super-SBM model with undesirable outputs. Based on the method of coupling coordination degree model, the coordinated development degree of DIG and SGTFP is analyzed first. Then, by making use of the fixed effect model, intermediary effect model and spatial Durbin model, the influence of DIG on the green development of SGMI and its mechanism are empirically studied. The results show that DIG, SGTFP and the degree of their coupling and coordination are generally on the rise. The benchmark regression results show that the coefficient of DIG on SGTFP is 0.213; that is, the digital economy can significantly promote the improvement of green development in SGMI. According to the analysis of the spatial Durbin model, the impact of the digital economy on SGTFP has a certain spatial spillover, that is, the development of digital economy in the region will have a certain promoting effect on the green development of SGMI in the surrounding region. The intermediary effect model analyzes the influence mechanism and finds that the digital economy mainly boosts SGTFP through green innovation technology and energy consumption structure.
Leadership is one of the important factors that ensured organizational achievement. Servant leadership offers a unique point of view on leadership which developed around the idea of service to subordinates. The implementation of servant leadership can lead to various positive outcomes, including increased engagement, organizational citizenship behavior, and improved performance. However, engagement and organizational citizenship behavior can serve as mediators to enhance organizational performance even further. The present study aimed to explore a prediction model of servant leadership using mediating variables such as employee engagement and organizational citizenship behavior, with employee performance as the outcome. The sampling method used was purposive sampling. This study used a structural equation model analysis approach to determine the predicted model of servant leadership. The research showed that the role of mediating variables indicated that employee engagement and organizational citizenship behavior had a positive effect in mediating the relationship between servant leadership and employee performance. The study indicated that applying servant leadership, with employee engagement, and organizational citizenship behavior as mediating variables would have an impact on better results of employee performance.
Purpose—In the business sector, reliable and timely data are crucial for business management to formulate a company’s strategy and enhance supply chain efficiency. The main goal of this study is to examine how strong brand strength affects shareholder value with a new Supplier Relationship Management System (SRMS) and to find the specific system qualities that are linked to SRMS adoption. This leads to higher brand strength and stronger shareholder value. Design/Methodology/Approach—This study employed a cross-sectional design with an explanatory survey as a deductive technique to form hypotheses. The primary method of data collection used a drop-off questionnaire that was self-administered to the UAE-based healthcare suppliers. Of the 787 questionnaires sent to the healthcare suppliers, 602 were usable, yielding a response rate of 76.5%. To analyze the data gathered, the study used Partial Least Squares Structural Equation modelling (PLS-SEM) and artificial neural network (ANN) techniques. Findings—The study’s data proved that SRMS adoption and brand strength positively affected and improved healthcare suppliers’ shareholder value. Additionally, it demonstrates that user satisfaction is the most significant predictor of SRMS adoption, while the results show that the mediating role of brand strength is the most significant predictor of shareholder value. The results demonstrated that internally derived constructs were better explained by the ANN technique than by the PLS-SEM approach. Originality/Value—This study demonstrates its practical value by offering decision-makers in the healthcare supplier industry a reference on what to avoid and what elements to take into account when creating plans and implementing strategies and policies.
This paper foresees a critical analysis and development of a legislative proposal for the effective implementation of blockchain technology in Civil Mediation in conflicts in condominiums. This paper provides a legal analysis of personal, property rights and condominium disputes, applying blockchain technology for the purpose of self-executing civil mediation. This paper provides several solutions for conflicts in condominiums: Condominium Statute in blockchain, telematic attendance and voting systems, the self-execution of civil mediation agreements in conflicts in condominiums and Tokenization and IoT for property remote control in condominiums. The novelty of this research lies in the fact that, based on the experience of civil mediation in conflicts in condominiums, foreseen in US States and in other States such as Canada, Spain, the regulation is adapted for the correct application of blockchain technology for mediation in conflicts in condominiums.
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