Projects implemented under life cycle contracts have become increasingly common in recent years to ensure the quality of construction and maintenance of energy infrastructure facilities. A key parameter for energy facility construction projects implemented under life cycle contracts is their duration and deadlines. Therefore, the systematic identification, monitoring, and comprehensive assessment of risks affecting the timing of work on the design and construction is an urgent practical task. The purpose of this work is to study the strength of the influence of various risks on the duration of a project implemented on the terms of a life cycle contract. The use of the expert assessment method allows for identifying the most likely risks for the design and construction phases, as well as determining the ranges of deviations from the baseline indicator. Using the obtained expert evaluations, a model reflecting the range and the most probable duration of the design and construction works under the influence of risk events was built by the Monte-Carlo statistical method. The results obtained allow monitoring and promptly detecting deviations in the actual duration of work from the basic deadlines set in the life cycle contract. This will give an opportunity to accurately respond to emerging risks and build a mutually beneficial relationship between the parties to life cycle contracts.

Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

In Emerging economies, MNCs (Multinational corporations) encounter several issues while devising Strategies to penetrate foreign markets, examining these SMEs’ performance in present times and assessing their internationalisation process is crucial. The purpose of this research is to investigate how international entrepreneurial orientation affects SMEs’ international performance during internationalization, as well as how organizational culture in the Kingdom influences the international performance of these MNCs. To attain this objective (n = 206) MNCs in the Kingdom have adopted internationalisation strategies. Questionnaires were administered as part of a survey approach for this study. To forecast and estimate relationships, partial least squares structural equation modelling (PLS-SEM) was employed. This study indicates that improving internationalization performance, mainly through active participation in foreign markets, is one of the SMEs’ strategies during the internationalization process. The empirical findings demonstrate that international entrepreneurial orientation influences the internationalisation performance of SMEs largely influenced by organisational culture. Previous research shows that the success of SMEs’ internationalization, however, is not directly impacted by their international entrepreneurial orientation. This study supports the significance of organisational culture during internationalisation. This study offers insightful information that motivates policymakers and owner-managers in developing nations, especially in KSA, to build organizational cultures and dynamic capacities that meet the demands of globalization in today’s business scenario.

In an effort to bridge the gap of economic and social inequality among the community, rural areas in Indonesia are encouraged to be self-sufficient in generating income. This makes the central government create various policies so that the regional government maximizes the management of its potential as an economic resource for the well-being of its people. One of the ways to manage this potential is to encourage rural areas to create tourism products that can be sold to the public. The Indonesian governments openly use the tourism sector as a tool for the development in many rural areas. Next, efforts to achieve successful development of the district will be closely related to the strategic planning and long-term cooperation of each local government with stakeholders in its implementation. These two points are the basic elements of the new regionalism theory. This theory states that the role of local governments is very important in initiating and making policies for new economic activities for a significant improvement in the quality of their population. Therefore, this study tries to explore how the new theory of regionalism can include rural development from a tourism perspective as a way to stimulate the fading economy in rural area of Indonesia. The study found that the new theory of regionalism needs support from various aspects such as social-cultural, community participation, the three pillars of sustainable development namely economic, social, and environmental as well as basic aspects to shape sustainable rural development through tourism.