In recent years, the pathological diagnosis of glomerular diseases typically involves the study of glomerular his-to pathology by specialized pathologists, who analyze tissue sections stained with Periodic Acid-Schiff (PAS) to assess tissue and cellular abnormalities. In recent years, the rapid development of generative adversarial networks composed of generators and discriminators has led to further developments in image colorization tasks. In this paper, we present a generative adversarial network by Spectral Normalization colorization designed for color restoration of grayscale images depicting glomerular cell tissue elements. The network consists of two structures: the generator and the discriminator. The generator incorporates a U-shaped decoder and encoder network to extract feature information from input images, extract features from Lab color space images, and predict color distribution. The discriminator network is responsible for optimizing the generated colorized images by comparing them with real stained images. On the Human Biomolecular Atlas Program (HubMAP)—Hacking the Kidney FTU segmentation challenge dataset, we achieved a peak signal-to-noise ratio of 29.802 dB, along with high structural similarity results as other colorization methods. This colorization method offers an approach to add color to grayscale images of glomerular cell tissue units. It facilitates the observation of physiological information in pathological images by doctors and patients, enabling better pathological-assisted diagnosis of certain kidney diseases.
This study explored the competencies required for informal community leaders to effectively promote health within Thai communities, employing an exploratory sequential mixed-methods design. The qualitative phase, comprising in-depth interviews with thirteen community leaders, identified four critical domains of competency: basic health knowledge, communication skills, network building, and cultural awareness. These domains were subsequently validated through second-order confirmatory factor analysis, which confirmed their reliability and construct validity. The findings highlighted the pivotal role of these competencies in enabling community-led health promotion initiatives. This research provides a robust, evidence-based framework to inform the development of training programs, policy strategies, and targeted interventions aimed at enhancing health outcomes within Thai communities.
This research introduces a novel framework integrating stochastic finite element analysis (FEA) with advanced circular statistical methods to optimize heat pump efficiency under material uncertainties. By modeling directional variability in thermal conductivity using both uniform and Von Mises distributions, the study highlights the superiority of the Von Mises distribution in providing consistent and efficient thermal performance. The Von Mises distribution, known for its concentration around a mean direction, demonstrates a significant advantage over the uniform distribution, resulting in higher mean efficiency and lower variability. The findings underscore the importance of considering both stochastic effects and directional consistency in thermal systems, paving the way for more robust and reliable design strategies.
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