The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

The debate on the effect of work environment on job satisfaction is very inconclusive. Most of the existing literature has focused on either the developed economy or job satisfaction and other variables other than the dimensions of the work environment. To fill the contextual and conceptual gap this study examined the effect of dimensions of work environment on job satisfaction among public sector workers in a developing economy. The study used the quantitative method and positivist philosophical viewpoint but specifically, the explanatory design was used to guide the study. A structured questionnaire was used for data collection and data analysis was done by partial least square modelling. The study found that the three dimensions of work environment such as physical, psychological and administrative work environment had a significant relationship with job satisfaction among public workers in a developing economy. It was recommended that the management of public sector organisations should improve upon the psychological, physical and administrative work environment to ensure job satisfaction among their workers. 

The aim of this study was to assess the challenges of rural landholding rights of women in Boloso sore Woreda. The population that used as source of data were sample womenfrom four kebeles,Kebele land administration committee members,Woreda women,youth and children office head,Woreda women’s association president,Woreda agriculture office head and Woreda agriculture office rural land administration desk experts.four kebeles from 28 rural kebeles selected by using systematic random sampling. Data gathered using questionnaire were analyzed using SPSS where descriptive and inferential were used for the purpose. Secondary data were collected from different relevant literatures such as reports, research results documents and publications. As to the findings,women landholding trend in the study area was highly contrasts legally ensured equal holding and using rights of women with men.The community including women themselves perceive women independent landholding as taboo and prohibits it.Even if they hold by different means,the plot of land they got or held was small in size and not conducive for agriculture and house construction. The awareness of women on rural land registration and certification benefit was also poor. Thus,rural women should be initiated to organize and struggle for their equal landholding and administering rights.

The sense of belonging in any organization is vital to generate a work motivation with the objective of a good organizational performance, because of this, companies usually take this point into account, ensuring that this leads to greater performance. For this reason, the objective of this article is to determine the relationship between the sense of belonging and the work motivation in the workers of a small Peruvian research company. For this purpose, a quantitative methodology was used, with a cross-sectional descriptive design. The instrument used was a survey consisting of 10 items, which were interpreted using the Likert scale. The survey was conducted and delivered to 24 workers, who were selected by non-probabilistic convenience sampling. After verifying the validity of the instrument and the study variables by means of Cronbach's Alpha statistic, we proceeded to determine the existence of correlation between the variables, which, using Spearman's Rho coefficient, obtained a 70.2% which demonstrates a moderate positive correlation, therefore it indicates that employees feel highly motivated as they feel an indispensable part of the company, therefore they feel job satisfaction by being part of the organization.

Fungi can be used to remove or degrade polluting compounds through a mycoremediation process. Sometimes even more efficiently than prokaryotes, they can therefore be used to combat pollution from non-biodegradable polymers. Cellulose acetate is a commonly used material in the manufacture of cigarette butts, so when discarded, it generates pollution. The fungus Pleurotus ostreatus has the ability to degrade cellulose acetate through the enzymes it secretes. The enzyme hydrolyzes the acetyl group of cellulose acetate, while cellulolytic enzymes degrade the cellulose backbone into sugars, polysaccharides, or cellobiose. In addition to cellulose acetate, this fungus is capable of degrading other conventionally non-biodegradable polymers, so it has the potential to be used to reduce pollution. Large-scale cultivation of the fungus has proven to be more economically viable than conventional methods for treating non-biodegradable polymers, which is an additional advantage.

Soil erosion is characterized by the wearing away or loss of the uppermost layer of soil, driven by water, wind, and human activities. This process constitutes a significant environmental issue, with adverse effects on water quality, soil health, and the overall stability of ecosystems across the globe. This study focuses on the Anuppur district of Madhya Pradesh, India, employing the Revised Universal Soil Loss Equation (RUSLE) integrated with Geographic Information System (GIS) tools to estimate and spatially analyze soil erosion and fertility risk. The various factors of the model, like rainfall erosivity (R), soil erodibility (K), slope length and steepness (LS), conservation practices (P), and cover management factor (C), have been computed to measure annual soil loss in the district. Each factor was derived using geospatial datasets, including rainfall records, soil characteristics, a Digital Elevation Model (DEM), land use/land cover (LULC) data, and information on conservation practices. GIS methods are used to map the geographical variation of soil erosion, providing important information on the area’s most susceptible to erosion. The outcome of the study reveals that 3371.23 km², which constitutes 91% of the district’s total area, is identified as having mild soil erosion; in contrast, 154 km², or 4%, is classified as moderate soil erosion, while 92 km², representing 2.5%, falls under the high soil erosion category. Ad