Objectives: The unprecedented COVID-19 pandemic has intensified the stress on blood banks and deprived the blood sources due to the containment measures that restrict the movement and travel limitations among blood donors. During this time, Malaysia had a significant 40% reduction in blood supply. Blood centers and hospitals faced a huge challenge balancing blood demand and collection. The health care systems need a proactive plan to withstand the uncertain situation such as the COVID-19 pandemic. This study investigates the psychosocial factors that affect blood donation behavior during a pandemic and aims to propose evidence-based strategies for a sustainable blood supply. Study design: Qualitative design using focus group discussion (FGD) was employed. Methods: Data were acquired from the two FGDs that group from transfusion medicine specialists (N = 8) and donors (N = 10). The FGD interview protocol was developed based on the UTM Research Ethics Committee’s approval. Then, the data was analyzed using Nvivo based on the General Inductive Approach (GIA). Results: Analysis of the text data found that the psychology of blood donation during the pandemic in Malaysia can be classified into four main themes: (i) reduced donation; (ii) motivation of donating blood; (iii) trends of donation; and (iv) challenges faced by the one-off, occasional, and non-donors. Conclusions: Based on the emerging themes from the FGDs, this study proposes four psycho-contextual strategies for relevant authorities to manage sustainable blood accumulation during the pandemic: (1) develop standard operating procedure for blood donors; (2) organize awareness campaigns; (3) create a centralized integrated blood donors database; and (4) provide innovative Blood Donation Facilities.

This study analyzes the dynamic relationships between tourism, gross domestic product (GDP) per capita, exports, imports, and carbon dioxide (CO₂) emissions in five South Asian countries. A VAR-based Granger causality test is performed with time series data from Bangladesh, India, Nepal, Pakistan, and Sri Lanka. According to the results, both bidirectional and unidirectional relationships among tourism, economic growth, and carbon emissions are investigated. Specifically, tourism significantly impacts GDP per capita in Pakistan, Sri Lanka, and Nepal, yet it has no effect in Bangladesh or India. However, the GDP per capita shows a unidirectional relationship with tourism in Bangladesh and India. The unidirectional causal relationship from exports and imports to tourism in the context of India and a bidirectional relationship in the case of Nepal. In Pakistan, it is observed that exports have a one-way influence on tourism. The result of the panel Granger test shows a significant causal association between tourism, economic growth, and trade (import and export) in five South Asian economies. Particularly, there is a bidirectional causal relationship between GDP per capita and tourism, and a significant unidirectional causal relationship from CO₂ emissions, exports, and imports to tourism is explored. The findings of this study are helpful for tourism stakeholders and policymakers in the region to formulate more sustainable and effective tourism strategies.

The electron/hole transport layer can promote charge transfer and improve device performance, which is used in perovskite solar cells. The nanoarray structure transport layers can not only further promote carrier transport but also reduce recombination. It also has a great potential in enhancing perovskite light absorption, improving device stability and inhibiting the crack nucleation of different structure layers in perovskite solar cells. This paper reviewed the research progress of perovskite solar cells with different nanoarray structure transport layers. The challenges and development directions of perovskite solar cells based on nanoarray structure transport layers are also summarized and prospected.

Cysteine is one of the body’s essential amino acids to build proteins. For the early diagnosis of a number of diseases and biological issues, L-cysteine (L-Cys) is essential. Our study presents an electrochemical sensor that detects L-cysteine by immobilizing the horseradish peroxidase (HRP) enzyme on a reduced graphene oxide (GCE) modified glassy carbon electrode. The morphologies and chemical compositions of synthesized materials were examined using Fourier transform infrared spectroscopy (FTIR) and field-emission scanning electron microscopy (FESEM). The modified electrode’s electrochemical behavior was investigated using cyclic voltammetry (CV). Cyclic voltammetry demonstrated HRP/rGO/GCE has better electrocatalytic activity than bare GCE in the oxidation of L-cysteine oxidation in a solution of acetate buffer. The electrochemical sensor had a broad linear range of 0 µM to 1 mM, a 0.32 µM detection limit, and a sensitivity of 6.08 μA μM⁻¹ cm⁻². The developed sensor was successfully used for the L-cysteine detection in a real blood sample with good results.

Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.