We report on the measurement of the response of Rhodamine 6G (R6G) dye to enhanced local surface plasmon resonance (LSPR) using a plasmonic-active nanostructured thin gold film (PANTF) sensor. This sensor features an active area of approximately ≈ 2.5 × 1013 nm2 and is immobilized with gold nanourchins (GNU) on a thin gold film substrate (TGFS). The hexane-functionalized TGFS was immobilized with a 90 nm diameter GNU via the strong sulfhydryl group (SH) thiol bond and excited by a 637 nm Raman probe. To collect both Raman and SERS spectra, 10 μL of R6G was used at concentrations of 1 μM (6 × 1012 molecules) and 10 mM (600 × 1014 molecules), respectively. FT-NIR showed a higher reflectivity of PANTF than TGFS. SERS was performed three times at three different laser powers for TGFS and PANTF with R6G. Two PANTF substrates were prepared at different GNU incubation times of 10 and 60 min for the purpose of comparison. The code for processing the data was written in Python. The data was filtered using the filtfilt filter from scipy.signals, and baseline corrected using the Improved Asymmetric Least Squares (ISALS) function from the pybaselines.Whittaker library. The results were then normalized using the minmax_scale function from sklearn.preprocessing. Atomic force microscopy (AFM) was used to capture the topography of the substrates. Signals exhibited a stochastic fluctuation in intensity and shape. An average corresponding enhancement factor (EF) of 0.3 × 105 and 0.14 × 105 was determinedforPANTFincubated at 10 and 60 min, respectively.
This research aims to identify the development of research theme trends that were carried out from 1999 to 2024. Thus, the study’s results can provide recommendations regarding research themes that can be developed to meet theoretical and practical needs. Researchers use bibliometric analysis to obtain the appropriate analysis. This analysis method can be developed to support the dynamic development of public health science with settings and researchers from developing countries, both through quantitative and qualitative interpretation. The analysis results show that over 25 years, public health science, from the perspective of researchers and developing countries, has experienced dynamic development. This change was driven by the emergence of various issues in society itself. For example, the 1999–2009 shows that lifestyle changes have resulted in multiple diseases. In the following period, the concept of sustainability emerged, which encouraged awareness of sustainable development and resource scarcity that would affect public health quality. As for the 2020–2024 period, the emergence of Covid 19 changed the previous research paradigm.
Recent times have seen significant advancements in AI and NLP technologies, poised to revolutionize logistical decision-making across industries. This study investigates integrating ChatGPT, an advanced AI language model, into strategic, tactical, and operational logistics. Examining its applicability, benefits, and limitations, the study delves into ChatGPT's capacity for strategic logistics planning, facilitating nuanced decision-making through natural language interactions. At the tactical level, it explores ChatGPT's role in optimizing route planning and enhancing real-time decision support. The operational aspect scrutinizes ChatGPT's capabilities in micro-level logistics and emergency response. Ethical implications, encompassing data security and human-AI trust dynamics, are also analyzed. This report furnishes valuable insights for the logistics sector, emphasizing AI's potential in reshaping decision-making while underscoring the necessity for foresight, evaluation, and ethical considerations in AI integration. In this publication, it is assumed that ChatGPT is not entirely reliable for decision-making in the logistics field: at the strategic level, it can be effectively used for "brainstormin" in preparing decisions, but at the tactical and operational level, the depth of the knowledge is not sufficient to make appropriate decisions. Therefore, the answers provided by ChatGPT to the defined logistic tasks are compared with real logistic solutions. The article highlights ChatGPT's effectiveness at different levels of logistics and clarifies its potential and limitations in the logistics field.
Delay is the leading challenge in completing Engineering, Procurement, and Construction (EPC) projects. Delay can cause excess costs, which reduces company profits. The relationship between subcontractors and the main contractor is a critical factor that can support the success of an EPC project. The problematic financial condition of the main contractor can cause delay in payments to subcontractors. This research will set a model that combines the system dynamics and earned value method to describe the impact of subcontractor advance payments on project performance. The system dynamics method is used to model and analyze the impact of interactions between variables affecting project performance, while the earned value method is applied to quantitatively evaluate project performance and forecast schedule and cost outcomes. These two methods are used complementarily to achieve a holistic understanding of project dynamics and to optimize decision-making. The designed model selects the optimum scenario for project time and costs. The developed model comprises project performance, costs, cash flow, and performance forecasting sub-models. The novelty in this research is a new model for optimizing project implementation time and costs, adding payment rate variables to subcontractors and subcontractor performance rates. The designed model can provide additional information to assist project managers in making decisions.
Protein- and peptide-based medications are recognized for their effectiveness and lower toxicity compared to chemical-based drugs, making them promising therapeutic agents. However, their application has been limited by numerous delivery challenges. Polymeric nanostructures have emerged as effective tools for protein delivery due to their versatility and customizability. Polymers’ inherent adaptability makes them ideal for meeting the specific demands of protein-delivery systems. Various strategies have been employed, such as enzyme inhibitors, absorption enhancers, mucoadhesive polymers, and chemical modifications of proteins or peptides. This study explores the hurdles associated with protein and peptide transport, the use of polymeric nanocarriers (both natural and synthetic) to overcome these challenges, and the techniques for fabricating and characterizing nanoparticles.
Indonesia’s tourism industry has emerged as a strategic sector, contributing to the country’s foreign exchange earnings. Given the prominence of this sector, there is significant potential for further development. Indeed, a mapping study to assess the dissemination of the trend and the potential for further issues to emerge would be highly beneficial. It is encouraging to note that academics have produced substantial literature on the subject, offering insights into its many facets. However, there is still a need for more in-depth analysis to understand the trends and issues currently facing the sector entirely. Consequently, this article examines the core themes in Indonesia’s tourism studies and maps the potential for future research on tourism issues and regulations. To this end, it employs a qualitative, four-year data set (2020–2023) and a SWOT analysis to identify critical aspects of Indonesian tourism issues. The data was collected in three forms: government reports, statistical data, and research articles (n = 252 samples) from the Scopus database. The results demonstrate that the predominant trend in Indonesia’s tourism industry is the widespread embrace of ecotourism at both the local and regional levels. Instead of identifying a limited number of leading destinations, the focus has shifted towards developing tourism villages and multi-stakeholder tourism. The primary concerns are the Indonesian tourism industry’s growth potential and sustainability. The development potential of Indonesian destinations based on SWOT objectives is a crucial aspect, and its score shows that Indonesia’s tourism sector is strategically positioned to take advantage of strengths and opportunities.
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