Instant and accurate evaluation of drug resistance in tumors before and during chemotherapy is important for patients with advanced colon cancer and is beneficial for prolonging their progression-free survival time. Here, the possible biomarkers that reflect the drug resistance of colon cancer were investigated using proton magnetic resonance spectroscopy (1H-MRS) in vivo. SW480[5-fluorouracil(5-FU)-responsive] and SW480/5-FU (5-FU-resistant) xenograft models were generated and subjected to in vivo 1H-MRS examinations when the maximum tumor diameter reached 1–1.5 cm. The areas under the peaks for metabolites, including choline (Cho), lactate (Lac), glutamine/glutamate (Glx), and myoinositol (Ins)/creatine (Cr) in the tumors, were analyzed between two groups. The resistancerelated protein expression, cell morphology, necrosis, apoptosis, and cell survival of these tumor specimens were assessed. The content for tCho, Lac, Glx, and Ins/Cr in the tumors of the SW480 group was significantly lower than that of the SW480/5-FU group (p < 0.05). While there was no significant difference in the degree of necrosis and apoptosis rate of tumor cells between the two groups (p > 0.05), the tumor cells of the SW480/5-FU showed a higher cell density and larger nuclei. The expression levels of resistance-related proteins (P-gp, MPR1, PKC) in the SW480 group were lower than those in the SW480/5-FU group (p < 0.01). The survival rate of 5-FU-resistant colon cancer cells was significantly higher than that of 5-FUresponsive ones at 5-FU concentrations greater than 2.5 μg/mL (p < 0.05). These results suggest that alterations in tCho, Lac, Glx1, Glx2, and Ins/Cr detected by 1H-MRS may be used for monitoring tumor resistance to 5-FU in vivo.

This study conducts a systematic review to explore the applications of Artificial Intelligence (AI) in mobile learning to support indigenous communities in Malaysia. It also examines the AI techniques used more broadly in education. The main objectives of this research are to investigate the role of Artificial Intelligence (AI) in support the mobile learning and education and provide a taxonomy that shows the stages of process that used in this research and presents the main AI applications that used in mobile learning and education. To identify relevant studies, four reputable databases—ScienceDirect, Web of Science, IEEE Xplore, and Scopus—were systematically searched using predetermined inclusion/exclusion criteria. This screening process resulted in 50 studies which were further classified into groups: AI Technologies (19 studies), Machine Learning (11), Deep Learning (8), Chatbots/ChatGPT/WeChat (4), and Other (8). The results were analyzed taxonomically to provide a structured framework for understanding the diverse applications of AI in mobile learning and education. This review summarizes current research and organizes it into a taxonomy that reveals trends and techniques in using AI to support mobile learning, particularly for indigenous groups in Malaysia.

Total factor productivity (TFP) is essential for disentangling the determinants of economic growth, productivity, and the standard of living. Understanding the variations in TFP, however, is greatly challenging because of the many assumptions that comprise the theoretical growth framework. In this paper, we aim to explore the determinants of TFP growth for countries at different stages of information and communication technology (ICT) development. To address the endogenous nature of the associated growth variables, we implement a three-stage-least (3SLS) square panel regression to improve the efficiency and asymptomatic accuracy of the estimators. We find that transmission channels, such as financial openness and trade globalization, have contributed substantially to growth in both advanced and developing countries. However, we also discover that greater financial openness can undermine a country’s TFP growth if the financial system is not sufficiently developed. When time horizons are decomposed into pre-ICT development and post-ICT development periods, a significant crowding-out effect is observed between ICT investment and financial openness in the pre-period, implying that the allocation of resources is critical for countries in the developing stage. Trade and finance policies that are adopted by advanced and developed countries might not be ideal for underdeveloped countries. Discretion in choosing adequate policies regarding financial integration and trade liberalization is advised for these emerging countries.

The concept of sustainable urban mobility has gained increasing attention in recent years due to the challenges posed by rapid urbanization and environmental degradation. The objective of this study is to explore the role of on-demand transportation in promoting sustainable urban mobility, incorporating insights from customer interests and demands through survey analysis. To fulfill this objective, a mixed-methods approach was employed, combining a systematic literature review with survey analysis of customer interests and demands regarding on-demand transportation services. This study combines a systematic literature review and a targeted survey to provide a comprehensive analysis of sustainable urban mobility, addressing gaps in understanding customer preferences alongside technological and financial considerations. The literature review encompassed various aspects including technological advancements, regulatory frameworks, user preferences, and environmental impacts. The survey analysis involved collecting data on customer preferences, satisfaction levels, and suggestions for improving on-demand transportation services. The findings of the study revealed significant insights into customer interests and demands regarding on-demand transportation services. Analysis of survey data indicated that factors such as convenience, affordability, reliability, and environmental sustainability were key considerations for customers when choosing on-demand transportation options. Additionally, the survey identified specific areas for improvement, including service coverage, accessibility, and integration with existing transportation networks. By providing flexible, efficient, and environmentally friendly transportation options, on-demand services have the potential to reduce congestions, improve air quality, and enhance overall urban livability.

This paper provides a disaster resilience-based approach. For the definition of the approach, a three-step method (definition of components, analysis of the resilience pillars and definitions of resilience-based actions) has been followed. To validate the approach, an application scenario for mitigating the COVID-19 pandemic is provided in the paper. The proposed approach contributes to stimulating the co-responsibility quadruple helix of actors in the implementation of actions for disaster management. Moreover, the approach is adaptable and flexible, as it can be used to manage different kinds of disasters, adjusting or changing itself to meet specific needs.

The research objective is to affirm the play of gender diversity and the role of leaders in promoting the concept among businesses for growth and long-term sustainability. The detailed literature search indicated that the culture of gender diversity can only be implemented if the leader practices three key leadership elements, which are effective communication (EC), emotional intelligence (EI), and better decision-making (DM). The paper strives to project the importance of gender diversity in managing market competition, the role of a leader in managing gender diversity, and how gender diversity impacts business growth and sustainability. The paper provides a different model for organizational leaders to instill and promote diversity. The study undertook a literature research approach to gain an in-depth understanding of the leadership role based on the current pool of literature to identify the factors that could promote diversity. The literature review concurred with the importance of implementing gender diversity in the business and assessing the long-term growth and the critical role of leadership as an enabler. The research concluded that leaders are required to play an active role in promoting gender equality to ensure it would directly impact business growth. The study provides a potential conceptual framework for future research to take over subsequently using a quantitative or qualitative method.