Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

The purpose of the article is to present the results of analysis of newly industrialized countries in the context of sustainable development. The study took place within the framework of the Kaldor’s structural-economic model of the gross domestic product and the energy flow model, using the socio-economic systems power changes analyzing method. Within the context of the approach, an invariant coordinate system in energy units is considered, the necessary conditions for sustainable development are formulated, and the main parameters for assessing the potential for growth and development are determined. The article focuses on key issues regarding new concepts of sustainable development and methodology for assessing sustainable development using the concept of socioeconomics useful power for the countries of the newly industrialized economy a group of emerging countries that have made in short time period a qualitative transition in socio-economic development. Based on a new definition of sustainable development in energy units, development trends are formulated for the selected countries during 20 years for the period 2000–2019. Results of the study can be used to planning for the transition to sustainable development. The data of the Central Statistical Office of European Union, the World Bank and the United Nations Organization were used for calculations. Initial interpretation of the calculated data has been done for the largest newly industrialized countries Brazil, India and China in terms of the gross domestic product in the period 1990–2019. For comparison, data on USA are presented as countries with advanced economy.

This study analyzes the potential of making Uzbekistan’s taxation system more inclusive by introducing a tax incentive policy related to zakat (obligatory Islamic alms for the wealthy). Additionally, it explores the establishment of relevant institutions to facilitate zakat collection and distribution. The study employs the method of comparative legal research, combined with exploratory research techniques, to examine taxation and zakat systems in different countries. The study’s findings indicate that incorporating zakat incentives, either in the form of tax credits or deductions, into Uzbekistan’s taxation system can enhance the role of zakat institutions in the country’s economy and reduce tax evasion to some extent. Moreover, it proposes a preliminary model of zakat management for Uzbekistan based on conclusions of the comparative study of various countries and analysis of the national legislation. Finally, the research highlights the necessity of a systematic approach to educate the public about zakat obligations, which is crucial for operation of proposed zakat management model and improving compliance. The study provides essential policy recommendations, including the implementation of zakat tax incentives, enhancing public zakat literacy, and ensuring the efficient operation of zakat institutions. By adopting these measures, the government of Uzbekistan can foster a more equitable and effective taxation system, contributing to socioeconomic development and poverty alleviation.

Air cargo transportation accounts for less than 1% of the global trade volume, yet it represents approximately 35% of the total value of goods transported, highlighting its strategic importance in trade and economic development. This study investigates the relationship between domestic air cargo transport in Brazil and key macroeconomic variables, focusing on how regional economic dynamism, logistical infrastructure, and population density impact the country’s development. Using a panel data regression model covering the period from 2000 to 2020, the study analyzes the evolution of air cargo transportation and its role in redistributing economic growth across Brazil’s regions. The findings emphasize the key factors influencing the air cargo sector and demonstrate how these factors can be leveraged to optimize public policies and business strategies. This research provides valuable insights into the relevance of air cargo transportation for regional and national development, particularly in emerging economies like Brazil, offering guidance for the formulation of strategies that promote balanced economic growth across regions.

This paper provides a comparative perspective on infrastructure provision in developing Asia's three largest countries: China, India, and Indonesia. It discusses their achievements and shortfalls in providing network infrastructure (energy, transport, water, and telecommunications) over the past two decades. It documents how three quite distinct development paths—and very different levels of national saving and investment—were manifested in different trajectories of infrastructure provision. The paper then describes the institutional, economic, and policy factors that enabled or hindered progress in providing infrastructure. Here, contrasting levels of centralization of planning played a key role, as did countries’ differing abilities to mobilize infrastructure-related revenue streams such as user charges and land value capture. The paper then assesses future challenges for the three countries in providing infrastructure in a more integrated and sustainable way, and links these challenges with the global development agenda to which the three countries have committed. The concluding recommendations hope to provide a platform for further policy and research dialogue.

The paper considers an important problem of the successful development of social qualities in an individual using machine learning methods. Social qualities play an important role in forming personal and professional lives, and their development is becoming relevant in modern society. The paper presents an overview of modern research in social psychology and machine learning; besides, it describes the data analysis method to identify factors influencing success in the development of social qualities. By analyzing large amounts of data collected from various sources, the authors of the paper use machine learning algorithms, such as Kohonen maps, decision tree and neural networks, to identify relationships between different variables, including education, environment, personal characteristics, and the development of social skills. Experiments were conducted to analyze the considered datasets, which included the introduction of methods to find dependencies between the input and output parameters. Machine learning introduction to find factors influencing the development of individual social qualities has varying dependence accuracy. The study results could be useful for both practical purposes and further scientific research in social psychology and machine learning. The paper represents an important contribution to understanding the factors that contribute to the successful development of individual social skills and could be useful in the development of programs and interventions in this area. The main objective of the research was to study the functionalities of the machine learning algorithms and various models to predict the students’s success in learning.