Increasing the environmental friendliness of production systems is largely dependent on the effective organization of waste logistics within a single enterprise or a system of interconnected market participants. The purpose of this article is to develop and test a methodology for evaluating a data-based waste logistics model, followed by solutions to reduce the level of waste in production. The methodology is based on the principle of balance between the generation and beneficial use of waste. The information base is data from mandatory state reporting, which determines the applicability of the methodology at the level of enterprises and management departments. The methodology is presented step by step, indicating data processing algorithms, their convolution into waste turnover efficiency coefficients, classification of coefficient values and subsequent interpretation, typology of waste logistics models with access to targeted solutions to improve the environmental sustainability of production. The practical implementation results of the proposed approach are presented using the production example of chemical products. Plastics production in primary forms has been determined, characterized by the interorganizational use of waste and the return of waste to the production cycle. Production of finished plastic products, characterized by a priority for the sale of waste to other enterprises. The proposed methodology can be used by enterprises to diagnose existing models for organizing waste circulation and design their own economically feasible model of waste processing and disposal.