In the domain of public management, the concept of agency refers to the capacity of individuals or groups to effectively utilise power and resources to achieve certain goals. The formation of agency is significantly influenced by the external institutional environment and how actors perceive social structures. Thus, the agency to win a game can be generated as players familiarise with the game’s operations and understand the story line. But beyond this, there are also players who make mods on a non-profit basis, modifying the game’s program to meet the needs of others. mods, as a form of patching, are different from other fan-created mediated texts. Therefore, studying the agency in gaming community management, where both players and developers interact, offers valuable insights for understanding how to promote public participation, innovation, and effective governance in the context of public management. This approach bridges the gap between the digital world and real-world public management practices.
The rapid expansion of smart cities has led to the widespread deployment of Internet of Things (IoT) devices for real-time data collection and urban optimization. However, these interconnected systems face critical cybersecurity risks, including data tampering, unauthorized access, and privacy breaches. This paper proposes a blockchain-based framework designed to enhance the security, integrity, and resilience of IoT data in smart city environments. Leveraging a private blockchain, the system ensures decentralized, tamper-proof data storage, and transaction verification through digital signatures and a lightweight Proof of Work consensus mechanism. Smart contracts are employed to automate access control and respond to anomalies in real time. A Python-based simulation demonstrates the framework’s effectiveness in securing IoT communications. The system supports rapid transaction validation with minimal latency and enables timely detection of anomalous patterns through integrated machine learning. Evaluations show that the framework maintains consistent performance across diverse smart city components such as transportation, healthcare, and building security. These results highlight the potential of the proposed solution to enable secure, scalable, and real-time IoT ecosystems for modern urban infrastructures.
The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.
Polyurethane is a multipurpose polymer with valuable mechanical, thermal, and chemical stability, and countless other physical features. Polyurethanes can be processed as foam, elastomer, or fibers. This innovative overview is designed to uncover the present state and opportunities in the field of polyurethanes and their nanocomposite sponges. Special emphasis has been given to fundamentals of polyurethanes and foam materials, related nanocomposite categories, and associated properties and applications. According to literature so far, adding carbon nanoparticles such as graphene and carbon nanotube influenced cell structure, overall microstructure, electrical/thermal conductivity, mechanical/heat stability, of the resulting polyurethane nanocomposite foams. Such progressions enabled high tech applications in the fields such as electromagnetic interference shielding, shape memory, and biomedical materials, underscoring the need of integrating these macromolecular sponges on industrial level environmentally friendly designs. Future research must be intended to resolve key challenges related to manufacturing and applicability of polyurethane nanocomposite foams. In particular, material design optimization, invention of low price processing methods, appropriate choice of nanofiller type/contents, understanding and control of interfacial and structure-property interplay must be determined.
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