Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

Africa has been fighting against colonialism and Eurocentrism for a long time in an attempt to reverse the regime of oppression and socio-economic marginalization and exploitation, and take back control of its cultural identity and right to self-determination. This adventure requires the recognition and revitalisation of indigenous arts, culture, and law—all of which have been subjugated and ignored during colonial rule. Ironically, the situation has not improved much by the dominating presence of post-independent neo-colonial structures and perpetuated Eurocentric phenomenon that have been ingrained into the socio-cultural and economic fabrics of the African state. This research explores the critical need for integrating science on African indigenous arts, culture, and legal systems, as a way of globalizing as well as revitalizing these elements, towards the ultimate emancipation of the continent from the vestiges of colonialism and Eurocentricism. Relying on the postcolonial, and indigenous knowledge systems theoretical frameworks, the study engages the ethnographic, collaborative and interdisciplinary research approaches, subjecting data obtained to thematic analysis. Underscoring the profound interconnectedness of science, indigenous arts, and cultural heritage, the study argues that combining scientific methods with indigenous African epistemology provides a powerful framework for advancing Africa’s true independence from the protracted legacies of colonialism and Eurocentrism. The research concludes that a holistic integration of these elements therefore, is indispensable for fostering a decolonized and inclusive approach to knowledge production, self-determination and sustainable development, against the background of the rich insights and sustainable practices embedded within the African cultural traditions. Ultimately, the research recommends that embracing and integrating science on indigenous epistemologies can propel Africa towards an emancipated, truly independent, and culturally affirming future, transcending the enduring legacies of colonialism and Eurocentrism.

The paper reports on the results of research on the institution of public-private partnerships in the field of implementation of state youth policy, particularly through socially important social youth projects, including social-entrepreneurial. The study explores social projects that enjoy the full range of support from all subjects in public-private partnerships: the state represented by public authorities, business structures, non-profit organizations, and youth. The authors highlight that the infrastructure of youth policy in the implementation of social-entrepreneurial youth projects needs to be changed conceptually. There is a need to establish comprehensive creative and professional spaces that shape young people’s personalities and practice a future-oriented model of organizing collaborative social projects.

The St. Peter Sandstone of the American Midwest is presented today in textbooks as a simple and unproblematic example of “layer-cake geology.” The thesis of this paper is that the very simplicity of St. Peter Sandstone has made it challenging to characterize. In widely separated states, the sandstone appeared under different names. Several theories about how it formed began to circulate. The story of the St. Peter is not only the story of the assemblage of a stratigraphic unit over a vast area during three centuries, but also the role the study of the provenance of this unit played in the development of sedimentology in the early twentieth century, research that was made all the more challenging by its “simple” mineralogy. Indeed, the St. Peter has been controversial since it was first described.

This work investigates epoxy composites reinforced by randomly oriented, short glass fibres and silica microparticles. A full-factorial experiment evaluates the effects of glass fibre mass fraction (15 wt% and 20 wt%) and length (5 mm and 10 mm), and the mass fraction of silica microparticles (5 wt% and 10 wt%) on the apparent density and porosity, as well as the compressive and tensile strength and modulus of the hybrid composites. Hybrid epoxy composites present significantly higher tensile strength (9%) and modulus (57%), as well as compressive strength (up to 15%) relative to pure epoxy.