Freeze-thawing plays a vital role in enhancing materials in medicines. Here, we describe the F-T process of synthesis of Poly (vinyl alcol)- Methylene blue single strand- Mxene (PVA–MB-ssDNA –Mxene), which may be effective for gen delivery applications. The PVA –MB-ssDNA –Mxene hydrogel was formed using 1,3,5 consecutive cycles. We also demonstrated that PVA –MB-ssDNA –Mxene hydrogel can be formed by the affection of DNA with PVA and the MXene network. The F-T process shows the new intra molecular bond of PVA-PVA, compared to the non F-T hydrogel which formed by a biologic crosslinking as MB-ssDNA. Scanning electron microscopy reported that the microstructure. The differential scan shows three endothermic peaks at 70, 180, and 300 ℃ for water loss and decomposition. The swelling behavior rapidly increased due to the PVA chains in the F-T methods and then became stable. With a high concentration of MB-DNA, the tensile strength was slightly high, and the swelling behavior was low. Our results indicated that the PVA –MB-ssDNA –Mxene hydrogel using F-T process would have more suitable structural features as gene hydrogel carrier which need greater mechanical strength and stability in body analyses.

Digital humanists play a crucial role in the modern international business world by combining the principles of regular employees with the advancements of digital technologies to address a variety of challenges and opportunities. They are specific labour forces that are driving digital transformation and innovation in the modern international business world. This article presents some key impacts the digital humanists have on global business practices and strategies particularly in the area of international business. Using the advantages, the digital era in which we live provides, digital humanists are becoming part of the international workforce but in a different and non-standard way. The main purpose of this article is to highlight some of the main characteristics of this modern workforce, the advantages and disadvantages of such an approach. It should be noted that the article is part of a scientific research dedicated to the changes in the international human resource management due to the technology developments and digitalization of the international business. The main research methods used are literature summary and analysis, comparative analysis, focus group interviews.

This study aims to identify key strategies and tactics necessary to effectively implement national social security in a democratic Indonesia. Indonesia established the Law on the National Social Security System in 2004. However, the national social security programs did not commence until 2014. The national social security implementation has faced significant obstacles. These challenges include recurring delays, legal disputes, appeals, judicial reviews, and deviations from the original policy objectives, all threatening the long-term viability of the national social security programs. This article applies a qualitative approach by critically analyzing regulations, government reports, and publicly available data and observing open public meetings and hearings concerning implementing national social security programs. Our findings indicate that implementing national social security policies in a democratic Indonesia depends on effectively managing the dynamic processes involved in policy formulation and adoption. We propose a risk-based decision-making model to assist policymakers in mitigating policy-related risks and enhance the effectiveness of future policy agendas in social security.

The aim of this article is to investigate the impediments to creativity perceived by managers, the levels of creativity, its indicators, and personal characteristics conducive to creativity, as well as to elucidate the correlations among them. An experimental study was conducted involving 300 participants. Methods employed include surveying, testing, and mathematical statistical analysis. As the level of creativity increases, participants tend to assess their opportunities more favorably. The expression of creativity depends on the interconnection among the barriers to creativity, indicators of creativity, and personal qualities of creativity. A high level of creativity is manifested when there are fewer barriers and personal qualities such as Imagination and a propensity for Risk-taking. Conversely, the level of expression of creativity is low when there is an interconnection between Creativity and Complexity, Imagination, and creativity barriers such as lack of confidence and conformity to majority opinion.

The six core competencies of mathematics in vocational schools are becoming increasingly important in mathematics learning. The reverse teaching design of vocational school mathematics, which focuses on core competencies, precisely grasps the internal logic of knowledge from a holistic perspective, and designs it on a unit by unit basis. The design process is to infer the starting point from the endpoint. Therefore, how to use reverse thinking in teaching design research in vocational school mathematics teaching under the background of core competencies will be the main content of this article.