This study evaluates the effectiveness of Indonesia's defense industry policy from 2018 to 2023, focusing on PT Pindad, a pivotal state-owned defense enterprise. Using a Balanced Scorecard (BSC) framework, the study assesses PT Pindad’s performance across financial, customer, internal process, and learning and growth perspectives. The findings reveal strengths in financial stability (Current Ratio at 115.57% in 2023) and customer satisfaction, but challenges in Return on Investment (ROI), which fell from 6% in 2022 to 5.46% in 2023, signaling a need for further internal improvements. A mediation analysis using Shape-Restricted Regression indicates that Research and Development (R&D) serves as a crucial mediator, enhancing the impact of strategic alliances and technology transfer on PT Pindad’s self-reliance, with R&D showing a positive coefficient of β = 0.53 (p < 0.01). The systematic literature review complements these findings, underscoring the role of technology transfer, human capital development, and strategic partnerships as essential components for strengthening PT Pindad’s self-reliance and global competitiveness. Recommendations are made to enhance policy effectiveness by fostering robust technology transfer mechanisms, increasing investment in human capital, and expanding strategic partnerships. This research contributes to the literature on defense industry policies by providing a comprehensive evaluation framework that informs future policy decisions.

There are several factors that generate postharvest losses of Citrus sinensis, but none have been focused on the central jungle of the Junín region of Peru. The objective of this research was to evaluate postharvest losses of Citrus sinensis in the province of Satipo, Junín region of Peru, considering the stages of the production chain. The methodology was applied to descriptive and cross-sectional design. A sample of 10 orange trees, 3 transport intermediaries and 5 traders selected for compliance with minimum volume and quality requirements were used. The °Brix, pH and acidity characteristics of the fruit were determined. Subsequently, absolute and percentage losses were quantified through direct observation, surveys and interviews. The main postharvest losses of Citrus sinensis were 1.50% in harvesting and detaching, 1.75% in transport to the collection center, 2.23% in storage and transport by intermediaries, and 2.90% in storage and sale by retailers. The overall loss was 8.12% throughout the production chain and US$5.75 per MT of C. sinensis harvested. The main damages found were mechanical and biological, caused by poor harvesting and packaging techniques, precarious storage and careless transport of the merchandise.

The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

This study explores the relationship between GDP growth, unemployment rate, and labor force participation rate in the Gulf Cooperation Council (GCC) countries from 1990 to 2018. Furthermore, the study incorporates control factors such as government spending, trade openness, and energy use into the regression equation. We used panel dynamic ordinary least squares (DOLS) and Fully Modified Ordinary Least Squares (FMOLS) estimators to investigate the relationships between variables in this investigation. The econometric technique accounts for nonstationary, endogeneity bias and cross-sectional dependencies between country-year observations. Cointegration was found among GDP growth, unemployment rate, and labor force participation. Long-term, the unemployment rate has a statistically significant negative effect on economic growth in the GCC nations. Meanwhile, the labor force participation rate significantly influences economic expansion in the long term. The expansion of government expenditures and international trade reduces economic growth. Alternatively, it is discovered that energy consumption has a substantial and positive effect on economic expansion. Okun’s rule and the unidirectional causality from economic growth to unemployment indicate that the primary cause of unemployment in GCC nations is a failure to adequately expand their economies. When developing economic strategies to reduce unemployment, policymakers are particularly interested in determining whether or not economic development and the unemployment rate are cointegrated.

Since 2007, Peru has implemented results-based budgeting in order to ensure the quality of public spending in State entities and that the population receives goods and services in a timely manner; However, the demands of the current legal and regulatory context require a progressive application to budget processes such as that of the National Penitentiary Institute, which is basically focused on the allocation of resources by the central government, the collections it receives for penitentiary work. and the TUPA; Likewise, it requires strategic programming based on results, refining the procedures for programming, formulation, execution and evaluation of the budget. The objective of this research work is to describe the relationship between results-based budget management and the quality of spending in the Altiplano-Puno Regional Directorate of the National Penitentiary Institute in the period 2019. To achieve the objective, the descriptive explanatory method was used; in addition, the questionnaire and documentary analysis were used as a data collection instrument to determine the relationship between the study variables. Finally, it is concluded that the results-based budget is significantly related to the quality of spending, which means that the entity managed to apply the results-based budgeting methodology efficiently, obtaining an improvement in the quality of spending, consequently focusing on the optimization of the use of financial resources to achieve the strategic objectives of the penitentiary administration in this region. This approach seeks not only to guarantee the correct execution of spending, but also to maximize its positive impact on the management and conditions of penitentiary centers. In this way, a results-based budget approach must be implemented and ensuring the quality of public spending will allow the Office Regional Altiplano Puno of the INPE use its resources more effectively, achieving the objectives of prison security and rehabilitation and improving conditions in penitentiary centers. The adoption of efficient and transparent management practices will contribute significantly to a more responsible and results-oriented public administration.