A comprehensive proteomic analysis was carried out to evaluate leaf proteome changes of Brassica napus cultivars as an important oilseed crop inoculated with the bacterium Pseudomonas fluorescens FY32 under salt stress. Based on the physiochemical characteristics of canola, Hyola308 was a tolerant and Sarigol was a salt sensitive cultivar. Gel-based proteomics indicated that proteins related to energy/metabolism, cell/membrane maintenance, signalins, stress, and development respond to salt stress and bacterial inoculation in both cultivars. Under salt stress, Hyola308 launches mechanisms similar to Sarigol, but the tolerance was related to consuming less energy consumption than Sarigol for launching the proper pathway/mechanism. Inoculation with plant growth promoting bacteria promotes relative growth rate and net assimilation rate; causes increase in soluble sugar content (12–32% varing to cultivars and salt treatments), as an osmo-protectant, in leaves of Sarigol and Hyola308 in control and salt stress conditions. The groups of proteins that are affected due to inoculation (18 and14 functional groups in Hyola308 and Sarigol, respectively) are varying to stress-influenced groups (10 and 6 functional groups in Hyola308 and Sarigol, respectively) that might be because of regulating tolerance mechanism of plant and/or plant-growth promoting bacteria inoculation. Furthermore, it is recognized that P. fluorescens FY32 has a dual effect on the cultivars including a pathogenic effect and a growth promoting effect on both cultivars under salt stress.
The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.
Ticket revenues are crucial for the financial success of sports teams. To maximize these revenues, teams continuously explore effective ticket promotional strategies. One such strategy includes partial season plans, which mirror bundle offers common across various industries. Another widespread promotional strategy across industries is offering discounted credit (i.e., store credit purchased at a lower price than its face value). However, its application in sports (e.g., providing a $500 credit for tickets at $450) remains limited. Therefore, this study explores critical questions such as: “How effective is offering discounted credit compared to partial season plans?” and “What factors influence ticket promotion preferences?” Consequently, the study employed a 2 × 2 × 2 experimental designs, considering three independent variables: promotion type (discounted credit vs. partial season plans), promotion flexibility (predefined vs. customizable), and the consumer’s distance to the venue (near vs. distant). Results indicated that partial season plans generated significantly higher perceived value and purchase intentions while presenting lower perceived risks than discounted credit . Promotion flexibility did not significantly influence the three dependent variables , but the distance to the venue did . Both practical and theoretical implications of these findings are discussed.
This study assesses Vietnam’s state-level implementation of artificial intelligence (AI) technology and analyses the government’s efforts to encourage AI implementation by focusing on the National Strategy on AI Development Program. This study emphasizes the possibility of implementing AI at the state level in Vietnam and the importance of conducting continuous reviews and enhancements to achieve sustainable and inclusive AI growth. Impact evaluations were conducted in public organizations alone, and implication evaluations were considered optional. AI impact assessments were constrained by societal norms that necessitated establishing relationships among findings. There is a lack of official information regarding the positive impact of Vietnam’s AI policy on the development of AI infrastructure, research, and talent pools. The study’s findings highlight the necessity of facilitating extensive AI legislation, and strengthening international cooperation. The study concludes with the following recommendations for improving Vietnam’s AI policy: implementing a strong AI governance structure and supporting AI education and awareness.
The banking sector is a pillar of the world’s economic fabric and is today facing a major revolution due to the demands of sustainable development objectives and the evolution of sustainable finance tools. This article analyses the impact of green credit on commercial banks’ performance based on data from 10 commercial banks in China between 2012 and 2022. The study found that in the short term, the implementation of green credit has a positive effect on the income level of commercial banks’ intermediate activities and a moderating effect on their return on total assets and non-performing loan ratio.
The relationship between transport infrastructure and accessibility has long stood as a central research area in regional and transport economics. Often invoked by governments to justify large public spending on infrastructure, the study of this relationship has led to conflicting arguments on the role that transport plays in productivity. This paper expands the existing body of knowledge by adopting a spatial analysis (with spillover effects) that considers the physical effects of investment in terms of accessibility (using distinct metrics). The authors have used the Portuguese experience at regional level over the last 30 years as a case study. The main conclusions are as follows: i) the choice of transport variables matters when explaining productivity, and more complex accessibility indicators are more correlated with; ii) it is important to account for spill-over effects; and iii) the evidence of granger causality is not widespread but depends on the regions.
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